Polymeric systems for delivery of growth factors to stimulate angiogenesis in tissue engineering

Research output: Contribution to conferencePaper

Abstract

To achieve controlled release of different growth factors at different periods (i.e. vascular endothelial growth factor (VEGF) followed by platelet-derived growth factor (PDGF)), and to investigate the effect of such release pattern on angiogenesis, we loaded model protein compounds BSA and lysozyme into microspheres based on PTMC with different molecular weights. Microspheres with size 1–50 µm and loading efficiencies higher than 75% were prepared. Microspheres loaded with VEGF and PDGF will be dispersed in PEG-PLA hydrogels and tested for stimulation of angiogenesis.
Original languageEnglish
Pagese52-e53
DOIs
Publication statusPublished - 2 Apr 2008
Event10th European Symposium on Controlled Drug Delivery, ESCDD 2008 - Noordwijk aan Zee, Netherlands
Duration: 2 Apr 20084 Apr 2008
Conference number: 10

Conference

Conference10th European Symposium on Controlled Drug Delivery, ESCDD 2008
Abbreviated titleESCDD
CountryNetherlands
CityNoordwijk aan Zee
Period2/04/084/04/08

Keywords

  • IR-69432
  • METIS-254006

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    Zhang, Z., Buwalda, S. J., Dijkstra, P. J., Grijpma, D. W., Poot, A. A., Steenbergen, W., & Feijen, J. (2008). Polymeric systems for delivery of growth factors to stimulate angiogenesis in tissue engineering. e52-e53. Paper presented at 10th European Symposium on Controlled Drug Delivery, ESCDD 2008, Noordwijk aan Zee, Netherlands. https://doi.org/10.1016/j.jconrel.2008.09.036