Polymeric systems for delivery of growth factors to stimulate angiogenesis in tissue engineering

Research output: Contribution to conferencePaperAcademic

Abstract

To achieve controlled release of different growth factors at different periods (i.e. vascular endothelial growth factor (VEGF) followed by platelet-derived growth factor (PDGF)), and to investigate the effect of such release pattern on angiogenesis, we loaded model protein compounds BSA and lysozyme into microspheres based on PTMC with different molecular weights. Microspheres with size 1–50 µm and loading efficiencies higher than 75% were prepared. Microspheres loaded with VEGF and PDGF will be dispersed in PEG-PLA hydrogels and tested for stimulation of angiogenesis.
Original languageEnglish
Pagese52-e53
DOIs
Publication statusPublished - 2 Apr 2008
Event10th European Symposium on Controlled Drug Delivery, ESCDD 2008 - Noordwijk aan Zee, Netherlands
Duration: 2 Apr 20084 Apr 2008
Conference number: 10

Conference

Conference10th European Symposium on Controlled Drug Delivery, ESCDD 2008
Abbreviated titleESCDD
CountryNetherlands
CityNoordwijk aan Zee
Period2/04/084/04/08

Fingerprint

Tissue Engineering
Microspheres
Intercellular Signaling Peptides and Proteins
Platelet-Derived Growth Factor
Vascular Endothelial Growth Factor A
Hydrogels
Muramidase
Molecular Weight
Proteins

Keywords

  • IR-69432
  • METIS-254006

Cite this

Zhang, Z., Buwalda, S. J., Dijkstra, P. J., Grijpma, D. W., Poot, A. A., Steenbergen, W., & Feijen, J. (2008). Polymeric systems for delivery of growth factors to stimulate angiogenesis in tissue engineering. e52-e53. Paper presented at 10th European Symposium on Controlled Drug Delivery, ESCDD 2008, Noordwijk aan Zee, Netherlands. https://doi.org/10.1016/j.jconrel.2008.09.036
Zhang, Z. ; Buwalda, S.J. ; Dijkstra, P.J. ; Grijpma, D.W. ; Poot, A.A. ; Steenbergen, W. ; Feijen, J. / Polymeric systems for delivery of growth factors to stimulate angiogenesis in tissue engineering. Paper presented at 10th European Symposium on Controlled Drug Delivery, ESCDD 2008, Noordwijk aan Zee, Netherlands.
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abstract = "To achieve controlled release of different growth factors at different periods (i.e. vascular endothelial growth factor (VEGF) followed by platelet-derived growth factor (PDGF)), and to investigate the effect of such release pattern on angiogenesis, we loaded model protein compounds BSA and lysozyme into microspheres based on PTMC with different molecular weights. Microspheres with size 1–50 µm and loading efficiencies higher than 75{\%} were prepared. Microspheres loaded with VEGF and PDGF will be dispersed in PEG-PLA hydrogels and tested for stimulation of angiogenesis.",
keywords = "IR-69432, METIS-254006",
author = "Z. Zhang and S.J. Buwalda and P.J. Dijkstra and D.W. Grijpma and A.A. Poot and W. Steenbergen and J. Feijen",
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Zhang, Z, Buwalda, SJ, Dijkstra, PJ, Grijpma, DW, Poot, AA, Steenbergen, W & Feijen, J 2008, 'Polymeric systems for delivery of growth factors to stimulate angiogenesis in tissue engineering' Paper presented at 10th European Symposium on Controlled Drug Delivery, ESCDD 2008, Noordwijk aan Zee, Netherlands, 2/04/08 - 4/04/08, pp. e52-e53. https://doi.org/10.1016/j.jconrel.2008.09.036

Polymeric systems for delivery of growth factors to stimulate angiogenesis in tissue engineering. / Zhang, Z.; Buwalda, S.J.; Dijkstra, P.J.; Grijpma, D.W.; Poot, A.A.; Steenbergen, W.; Feijen, J.

2008. e52-e53 Paper presented at 10th European Symposium on Controlled Drug Delivery, ESCDD 2008, Noordwijk aan Zee, Netherlands.

Research output: Contribution to conferencePaperAcademic

TY - CONF

T1 - Polymeric systems for delivery of growth factors to stimulate angiogenesis in tissue engineering

AU - Zhang, Z.

AU - Buwalda, S.J.

AU - Dijkstra, P.J.

AU - Grijpma, D.W.

AU - Poot, A.A.

AU - Steenbergen, W.

AU - Feijen, J.

PY - 2008/4/2

Y1 - 2008/4/2

N2 - To achieve controlled release of different growth factors at different periods (i.e. vascular endothelial growth factor (VEGF) followed by platelet-derived growth factor (PDGF)), and to investigate the effect of such release pattern on angiogenesis, we loaded model protein compounds BSA and lysozyme into microspheres based on PTMC with different molecular weights. Microspheres with size 1–50 µm and loading efficiencies higher than 75% were prepared. Microspheres loaded with VEGF and PDGF will be dispersed in PEG-PLA hydrogels and tested for stimulation of angiogenesis.

AB - To achieve controlled release of different growth factors at different periods (i.e. vascular endothelial growth factor (VEGF) followed by platelet-derived growth factor (PDGF)), and to investigate the effect of such release pattern on angiogenesis, we loaded model protein compounds BSA and lysozyme into microspheres based on PTMC with different molecular weights. Microspheres with size 1–50 µm and loading efficiencies higher than 75% were prepared. Microspheres loaded with VEGF and PDGF will be dispersed in PEG-PLA hydrogels and tested for stimulation of angiogenesis.

KW - IR-69432

KW - METIS-254006

U2 - 10.1016/j.jconrel.2008.09.036

DO - 10.1016/j.jconrel.2008.09.036

M3 - Paper

SP - e52-e53

ER -

Zhang Z, Buwalda SJ, Dijkstra PJ, Grijpma DW, Poot AA, Steenbergen W et al. Polymeric systems for delivery of growth factors to stimulate angiogenesis in tissue engineering. 2008. Paper presented at 10th European Symposium on Controlled Drug Delivery, ESCDD 2008, Noordwijk aan Zee, Netherlands. https://doi.org/10.1016/j.jconrel.2008.09.036