Poly(N-isopropylacrylamide)–poly(ferrocenylsilane) dual-responsive hydrogels: synthesis, characterization and antimicrobial applications

Xiaofeng Sui, Xueling Feng, Andrea Di Luca, Clemens van Blitterswijk, Lorenzo Moroni, Mark A. Hempenius, Gyula J. Vancso

Research output: Contribution to journalArticleAcademicpeer-review

47 Citations (Scopus)

Abstract

Novel hydrogels composed of thermo-responsive poly(N-isopropylacrylamide) (PNIPAM) and redox-responsive poly(ferrocenylsilane) (PFS) macromolecules were formed by photopolymerization. PFS chains bearing acrylate side groups were copolymerized with NIPAM and N,N′-methylenebisacrylamide in tetrahydrofuran in a predetermined ratio under ultraviolet light-emitting diode (UV-LED) irradiation at a wavelength of 365 nm, in the presence of a photoinitiator. Crosslinking occurred smoothly, providing homogeneous hydrogels. The equilibrium swelling ratio, rheology and morphology of these hybrid PNIPAM–PFS-based hydrogels were investigated. The thermo-responsive properties of the hydrogels were studied as a function of the PFS oxidation state. In situ fabrication of silver nanoparticles inside the hydrogel network via reduction of silver nitrate by the PFS chains led to hydrogel composites. These composites showed strong antimicrobial activity while maintaining a high biocompatibility with cells
Original languageEnglish
Pages (from-to)337-342
JournalPolymer chemistry
Volume4
Issue number2
DOIs
Publication statusPublished - 11 Sep 2013

Keywords

  • METIS-290969
  • IR-89890

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