Poly(trimethylene carbonate) and monomethoxy poly(ethylene glycol)-block-poly(trimethylene carbonate) nanoparticles for the controlled release of dexamethasone

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Abstract

In this study, single emulsion and salting out methods were employed to prepare poly(trimethylene carbonate) (PTMC) and monomethoxy poly(ethylene glycol)-block-poly(trimethylene carbonate) (mPEG–PTMC) nanoparticles. Well-defined nanoparticles of a PTMC homopolymer were prepared using poly(vinyl alcohol) (PVA) as a stabilizer. The average size of the nanoparticles can be adjusted by varying the stirring speed and polymer concentration. These particles can be readily freeze-dried and redispersed, with little influence on the average particle size and size distribution. Nanoparticles based on amphiphilic mPEG–PTMC can be prepared without an additional stabilizer. In this case, the size of the obtained nanoparticles did not vary much and ranged between 95 and 120 nm. These nanoparticles could be freeze-dried and redispersed as well. Using the salting out method, dexamethasone was loaded into PTMC and mPEG–PTMC nanoparticles at a highest efficiency of respectively 54% and 88%. With the single emulsion method, the loading efficiencies were, respectively, 91% and 72%. These drug-loaded particles were stable in time for at least 20 weeks. It was found that the release of dexamethasone from these nanoparticles was diffusion-controlled and could be sustained for 14 to 60 days. Depending on the nature of the polymer employed and the preparation method, dexamethasone diffusion coefficients varied between 4.8 × 10− 18 and 22.6 × 10− 18 cm2/s.
Original languageEnglish
Pages (from-to)263-270
JournalJournal of controlled release
Volume111
Issue number3
DOIs
Publication statusPublished - 2006

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Nanoparticles
Dexamethasone
Emulsions
Polymers
monomethoxy poly(ethylene glycol)-block-poly(trimethylene carbonate)
polytrimethylene carbonate
Particle Size
Alcohols
Pharmaceutical Preparations

Keywords

  • Nanoparticles
  • Dexamethasone
  • Poly(trimethylene carbonate)
  • Poly(ethylene glycol)-block-poly(trimethylene carbonate)
  • Controlled release

Cite this

@article{69eb5ac54fe743de8c4127702ab7e119,
title = "Poly(trimethylene carbonate) and monomethoxy poly(ethylene glycol)-block-poly(trimethylene carbonate) nanoparticles for the controlled release of dexamethasone",
abstract = "In this study, single emulsion and salting out methods were employed to prepare poly(trimethylene carbonate) (PTMC) and monomethoxy poly(ethylene glycol)-block-poly(trimethylene carbonate) (mPEG–PTMC) nanoparticles. Well-defined nanoparticles of a PTMC homopolymer were prepared using poly(vinyl alcohol) (PVA) as a stabilizer. The average size of the nanoparticles can be adjusted by varying the stirring speed and polymer concentration. These particles can be readily freeze-dried and redispersed, with little influence on the average particle size and size distribution. Nanoparticles based on amphiphilic mPEG–PTMC can be prepared without an additional stabilizer. In this case, the size of the obtained nanoparticles did not vary much and ranged between 95 and 120 nm. These nanoparticles could be freeze-dried and redispersed as well. Using the salting out method, dexamethasone was loaded into PTMC and mPEG–PTMC nanoparticles at a highest efficiency of respectively 54{\%} and 88{\%}. With the single emulsion method, the loading efficiencies were, respectively, 91{\%} and 72{\%}. These drug-loaded particles were stable in time for at least 20 weeks. It was found that the release of dexamethasone from these nanoparticles was diffusion-controlled and could be sustained for 14 to 60 days. Depending on the nature of the polymer employed and the preparation method, dexamethasone diffusion coefficients varied between 4.8 × 10− 18 and 22.6 × 10− 18 cm2/s.",
keywords = "Nanoparticles, Dexamethasone, Poly(trimethylene carbonate), Poly(ethylene glycol)-block-poly(trimethylene carbonate), Controlled release",
author = "Zheng Zhang and Grijpma, {Dirk W.} and Jan Feijen",
year = "2006",
doi = "10.1016/j.jconrel.2005.12.001",
language = "English",
volume = "111",
pages = "263--270",
journal = "Journal of controlled release",
issn = "0168-3659",
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TY - JOUR

T1 - Poly(trimethylene carbonate) and monomethoxy poly(ethylene glycol)-block-poly(trimethylene carbonate) nanoparticles for the controlled release of dexamethasone

AU - Zhang, Zheng

AU - Grijpma, Dirk W.

AU - Feijen, Jan

PY - 2006

Y1 - 2006

N2 - In this study, single emulsion and salting out methods were employed to prepare poly(trimethylene carbonate) (PTMC) and monomethoxy poly(ethylene glycol)-block-poly(trimethylene carbonate) (mPEG–PTMC) nanoparticles. Well-defined nanoparticles of a PTMC homopolymer were prepared using poly(vinyl alcohol) (PVA) as a stabilizer. The average size of the nanoparticles can be adjusted by varying the stirring speed and polymer concentration. These particles can be readily freeze-dried and redispersed, with little influence on the average particle size and size distribution. Nanoparticles based on amphiphilic mPEG–PTMC can be prepared without an additional stabilizer. In this case, the size of the obtained nanoparticles did not vary much and ranged between 95 and 120 nm. These nanoparticles could be freeze-dried and redispersed as well. Using the salting out method, dexamethasone was loaded into PTMC and mPEG–PTMC nanoparticles at a highest efficiency of respectively 54% and 88%. With the single emulsion method, the loading efficiencies were, respectively, 91% and 72%. These drug-loaded particles were stable in time for at least 20 weeks. It was found that the release of dexamethasone from these nanoparticles was diffusion-controlled and could be sustained for 14 to 60 days. Depending on the nature of the polymer employed and the preparation method, dexamethasone diffusion coefficients varied between 4.8 × 10− 18 and 22.6 × 10− 18 cm2/s.

AB - In this study, single emulsion and salting out methods were employed to prepare poly(trimethylene carbonate) (PTMC) and monomethoxy poly(ethylene glycol)-block-poly(trimethylene carbonate) (mPEG–PTMC) nanoparticles. Well-defined nanoparticles of a PTMC homopolymer were prepared using poly(vinyl alcohol) (PVA) as a stabilizer. The average size of the nanoparticles can be adjusted by varying the stirring speed and polymer concentration. These particles can be readily freeze-dried and redispersed, with little influence on the average particle size and size distribution. Nanoparticles based on amphiphilic mPEG–PTMC can be prepared without an additional stabilizer. In this case, the size of the obtained nanoparticles did not vary much and ranged between 95 and 120 nm. These nanoparticles could be freeze-dried and redispersed as well. Using the salting out method, dexamethasone was loaded into PTMC and mPEG–PTMC nanoparticles at a highest efficiency of respectively 54% and 88%. With the single emulsion method, the loading efficiencies were, respectively, 91% and 72%. These drug-loaded particles were stable in time for at least 20 weeks. It was found that the release of dexamethasone from these nanoparticles was diffusion-controlled and could be sustained for 14 to 60 days. Depending on the nature of the polymer employed and the preparation method, dexamethasone diffusion coefficients varied between 4.8 × 10− 18 and 22.6 × 10− 18 cm2/s.

KW - Nanoparticles

KW - Dexamethasone

KW - Poly(trimethylene carbonate)

KW - Poly(ethylene glycol)-block-poly(trimethylene carbonate)

KW - Controlled release

U2 - 10.1016/j.jconrel.2005.12.001

DO - 10.1016/j.jconrel.2005.12.001

M3 - Article

VL - 111

SP - 263

EP - 270

JO - Journal of controlled release

JF - Journal of controlled release

SN - 0168-3659

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ER -