Poly(trimethylene carbonate)-based composite materials for reconstruction of critical-sized cranial bone defects in sheep

Ni Zeng, Anne C. van Leeuwen, Dirk W. Grijpma, Ruud R.M. Bos, Roel Kuijer*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)
3 Downloads (Pure)


Purpose: The use of ceramic materials in repair of bone defects is limited to non-load-bearing sites. We tested poly(trimethylene carbonate) (PTMC) combined with β-tricalcium phosphate or biphasic calcium phosphate particles for reconstruction of cranial defects.

Materials and methods: PTMC-calcium phosphate composite matrices were implanted in cranial defects in sheep for 3 and 9 months. Micro-computed tomography quantification and histological observation were performed for analysis.

Results: No differences were found in new bone formation among the defects left unfilled, filled with PTMC scaffolds, or filled with either kind of PTMC-calcium phosphate composite scaffolds. Porous β-TCP scaffolds as control led to a larger amount of newly formed bone in the defects than all other materials. Histology revealed abundant new bone formation in the defects filled with porous β-TCP scaffolds. New bone formation was limited in defects filled with PTMC scaffolds or different PTMC-calcium phosphate matrices. PTMC matrices were degraded uneventfully. New bone formation within the defects followed an orderly pattern.

Conclusions: PTMC did not interfere with bone regeneration in sheep cranial defects and is suitable as a polymer matrix for incorporating calcium phosphate particles. Increasing the content of calcium phosphate particles in the composite matrices may enhance the beneficial effects of the particles on new bone formation.

Original languageEnglish
Pages (from-to)338-346
Number of pages9
JournalJournal of Cranio-Maxillo-Facial Surgery
Issue number2
Publication statusPublished - 1 Feb 2017


  • Animal study
  • Calcium phosphate
  • Ceramic
  • Composite
  • Cranial bone defect
  • Poly(trimethylene carbonate)
  • 2023 OA procedure

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