Poly(vinyl alcohol) gels for use as tissue phantoms in photoacousttc mammography

A. Kharine, Srirang Manohar, Rosalyn Seeton, R.G.M. Kolkman, R.A. Bolt, Wiendelt Steenbergen, F.F.M. de Mul

Research output: Contribution to journalArticleAcademicpeer-review

133 Citations (Scopus)

Abstract

Materials for solid photoacoustic breast phantoms, based on poly(vinyl alcohol) hydrogels, are presented. Phantoms intended for use in photoacoustics must possess both optical and acoustic properties of tissue. To realize the optical properties of tissue, one approach was to optimize the number of freezing and thawing cycles of aqueous poly(vinyl alcohol) solutions, a procedure which increases the turbidity of the gel while rigidifying it. The second approach concentrated on forming a clear matrix of the rigid poly(vinyl alcohol) gel without any scattering, so that appropriate amounts of optical scatterers could be added at the time of formation, to tune the optical properties as per requirement. The relevant optical and acoustic properties of such samples were measured to be close to the average properties of human breast tissue. Tumour simulating gel samples of suitable absorption coefficient were created by adding appropriate quantities of dye at the time of formation; the samples were then cut into spheres. A breast phantom embedded with such 'tumours' was developed for studying the applicability of photoacoustics in mammography.
Original languageUndefined
Pages (from-to)-
JournalPhysics in medicine and biology
Volume48
Issue number3
DOIs
Publication statusPublished - 2003

Keywords

  • METIS-211031
  • IR-40475

Cite this

Kharine, A. ; Manohar, Srirang ; Seeton, Rosalyn ; Kolkman, R.G.M. ; Bolt, R.A. ; Steenbergen, Wiendelt ; de Mul, F.F.M. / Poly(vinyl alcohol) gels for use as tissue phantoms in photoacousttc mammography. In: Physics in medicine and biology. 2003 ; Vol. 48, No. 3. pp. -.
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abstract = "Materials for solid photoacoustic breast phantoms, based on poly(vinyl alcohol) hydrogels, are presented. Phantoms intended for use in photoacoustics must possess both optical and acoustic properties of tissue. To realize the optical properties of tissue, one approach was to optimize the number of freezing and thawing cycles of aqueous poly(vinyl alcohol) solutions, a procedure which increases the turbidity of the gel while rigidifying it. The second approach concentrated on forming a clear matrix of the rigid poly(vinyl alcohol) gel without any scattering, so that appropriate amounts of optical scatterers could be added at the time of formation, to tune the optical properties as per requirement. The relevant optical and acoustic properties of such samples were measured to be close to the average properties of human breast tissue. Tumour simulating gel samples of suitable absorption coefficient were created by adding appropriate quantities of dye at the time of formation; the samples were then cut into spheres. A breast phantom embedded with such 'tumours' was developed for studying the applicability of photoacoustics in mammography.",
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Poly(vinyl alcohol) gels for use as tissue phantoms in photoacousttc mammography. / Kharine, A.; Manohar, Srirang; Seeton, Rosalyn; Kolkman, R.G.M.; Bolt, R.A.; Steenbergen, Wiendelt; de Mul, F.F.M.

In: Physics in medicine and biology, Vol. 48, No. 3, 2003, p. -.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Poly(vinyl alcohol) gels for use as tissue phantoms in photoacousttc mammography

AU - Kharine, A.

AU - Manohar, Srirang

AU - Seeton, Rosalyn

AU - Kolkman, R.G.M.

AU - Bolt, R.A.

AU - Steenbergen, Wiendelt

AU - de Mul, F.F.M.

PY - 2003

Y1 - 2003

N2 - Materials for solid photoacoustic breast phantoms, based on poly(vinyl alcohol) hydrogels, are presented. Phantoms intended for use in photoacoustics must possess both optical and acoustic properties of tissue. To realize the optical properties of tissue, one approach was to optimize the number of freezing and thawing cycles of aqueous poly(vinyl alcohol) solutions, a procedure which increases the turbidity of the gel while rigidifying it. The second approach concentrated on forming a clear matrix of the rigid poly(vinyl alcohol) gel without any scattering, so that appropriate amounts of optical scatterers could be added at the time of formation, to tune the optical properties as per requirement. The relevant optical and acoustic properties of such samples were measured to be close to the average properties of human breast tissue. Tumour simulating gel samples of suitable absorption coefficient were created by adding appropriate quantities of dye at the time of formation; the samples were then cut into spheres. A breast phantom embedded with such 'tumours' was developed for studying the applicability of photoacoustics in mammography.

AB - Materials for solid photoacoustic breast phantoms, based on poly(vinyl alcohol) hydrogels, are presented. Phantoms intended for use in photoacoustics must possess both optical and acoustic properties of tissue. To realize the optical properties of tissue, one approach was to optimize the number of freezing and thawing cycles of aqueous poly(vinyl alcohol) solutions, a procedure which increases the turbidity of the gel while rigidifying it. The second approach concentrated on forming a clear matrix of the rigid poly(vinyl alcohol) gel without any scattering, so that appropriate amounts of optical scatterers could be added at the time of formation, to tune the optical properties as per requirement. The relevant optical and acoustic properties of such samples were measured to be close to the average properties of human breast tissue. Tumour simulating gel samples of suitable absorption coefficient were created by adding appropriate quantities of dye at the time of formation; the samples were then cut into spheres. A breast phantom embedded with such 'tumours' was developed for studying the applicability of photoacoustics in mammography.

KW - METIS-211031

KW - IR-40475

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SP - -

JO - Physics in medicine and biology

JF - Physics in medicine and biology

SN - 0031-9155

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