Position-cortical coherence as a marker for somatosensory integrity early post-stroke, a prospective cohort study

S. Zandvliet, E. van Wegen, S. Campfens, H. van der Kooij, G. Kwakkel, C. Meskers

Research output: Contribution to conferencePosterAcademic

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Abstract

Introduction: Neurophysiological assessments in addition to clinical scales can potentially elucidate the role of somatosensory function in post-stroke motor recovery. Main objective:To investigate the longitudinal construct validity of positioncortical coherence (PCC), the agreement between evoked wrist perturbations and EEG, as a measure of afferent integrity, with respect to longitudinal recovery of sensorimotor function. Methods: PCC was measured serially in 48 patients after a fi rst-ever ischemic stroke, in addition to Fugl-Meyer motor assessment of the upper extremity (FM-UE) and Erasmus modifi cation of the Nottingham Sensory Assessment (EmNSA), within 3, 5, 12 and 26 weeks post-stroke. Change in PCC over time represented by: percentage presence of PCC (%PCC), mean amplitude of PCC over the affected hemisphere (Amp-A) were addressed as well as their association with FM-UE and EmNSA. Patients were classifi ed into: expectedfi tters (FM-UE-baseline=18 points), unexpected-fi tters (FM-UE-baseline<18 points) and non-fi tters (FM-UE-baseline<18 points), to the proportional recovery model. Results and discussion: %PCC increased from baseline to 12 weeks post-stroke (ß:1.6%, CI:0.32-2.86%, P=0.01), which was no longer signifi cant after adjusting for EmNSA and FM-UE. A signifi cant positive association was found between %PCC, Amp-A and EmNSA. Unexpected fi tters (N=8) showed longitudinally signifi cantly higher %PCC than those expected to fi t the proportional recovery model (N=23). Conclusion: We demonstrated the longitudinal construct validity of %PCC and Amp-A as a measure of afferent pathway integrity. A high %PCC in unexpected fi tters suggests that this marker contains information above afferent integrity, i.e. cortical excitability. More work is needed to improve clinical prediction models for functional outcome post-stroke.
Original languageEnglish
Pages88-88
Number of pages1
Publication statusPublished - 22 May 2019
Event3rd Congress on NeuroRehabilitation and Neural Repair 2019 - Maastricht, Netherlands
Duration: 22 May 201924 May 2019
Conference number: 3

Conference

Conference3rd Congress on NeuroRehabilitation and Neural Repair 2019
CountryNetherlands
CityMaastricht
Period22/05/1924/05/19

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Upper Extremity
Cohort Studies
Stroke
Prospective Studies
Cations
Afferent Pathways
Recovery of Function
Wrist
Electroencephalography

Cite this

Zandvliet, S., van Wegen, E., Campfens, S., van der Kooij, H., Kwakkel, G., & Meskers, C. (2019). Position-cortical coherence as a marker for somatosensory integrity early post-stroke, a prospective cohort study. 88-88. Poster session presented at 3rd Congress on NeuroRehabilitation and Neural Repair 2019, Maastricht, Netherlands.
Zandvliet, S. ; van Wegen, E. ; Campfens, S. ; van der Kooij, H. ; Kwakkel, G. ; Meskers, C. / Position-cortical coherence as a marker for somatosensory integrity early post-stroke, a prospective cohort study. Poster session presented at 3rd Congress on NeuroRehabilitation and Neural Repair 2019, Maastricht, Netherlands.1 p.
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title = "Position-cortical coherence as a marker for somatosensory integrity early post-stroke, a prospective cohort study",
abstract = "Introduction: Neurophysiological assessments in addition to clinical scales can potentially elucidate the role of somatosensory function in post-stroke motor recovery. Main objective:To investigate the longitudinal construct validity of positioncortical coherence (PCC), the agreement between evoked wrist perturbations and EEG, as a measure of afferent integrity, with respect to longitudinal recovery of sensorimotor function. Methods: PCC was measured serially in 48 patients after a fi rst-ever ischemic stroke, in addition to Fugl-Meyer motor assessment of the upper extremity (FM-UE) and Erasmus modifi cation of the Nottingham Sensory Assessment (EmNSA), within 3, 5, 12 and 26 weeks post-stroke. Change in PCC over time represented by: percentage presence of PCC ({\%}PCC), mean amplitude of PCC over the affected hemisphere (Amp-A) were addressed as well as their association with FM-UE and EmNSA. Patients were classifi ed into: expectedfi tters (FM-UE-baseline=18 points), unexpected-fi tters (FM-UE-baseline<18 points) and non-fi tters (FM-UE-baseline<18 points), to the proportional recovery model. Results and discussion: {\%}PCC increased from baseline to 12 weeks post-stroke ({\ss}:1.6{\%}, CI:0.32-2.86{\%}, P=0.01), which was no longer signifi cant after adjusting for EmNSA and FM-UE. A signifi cant positive association was found between {\%}PCC, Amp-A and EmNSA. Unexpected fi tters (N=8) showed longitudinally signifi cantly higher {\%}PCC than those expected to fi t the proportional recovery model (N=23). Conclusion: We demonstrated the longitudinal construct validity of {\%}PCC and Amp-A as a measure of afferent pathway integrity. A high {\%}PCC in unexpected fi tters suggests that this marker contains information above afferent integrity, i.e. cortical excitability. More work is needed to improve clinical prediction models for functional outcome post-stroke.",
author = "S. Zandvliet and {van Wegen}, E. and S. Campfens and {van der Kooij}, H. and G. Kwakkel and C. Meskers",
year = "2019",
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note = "3rd Congress on NeuroRehabilitation and Neural Repair 2019 ; Conference date: 22-05-2019 Through 24-05-2019",

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Zandvliet, S, van Wegen, E, Campfens, S, van der Kooij, H, Kwakkel, G & Meskers, C 2019, 'Position-cortical coherence as a marker for somatosensory integrity early post-stroke, a prospective cohort study' 3rd Congress on NeuroRehabilitation and Neural Repair 2019, Maastricht, Netherlands, 22/05/19 - 24/05/19, pp. 88-88.

Position-cortical coherence as a marker for somatosensory integrity early post-stroke, a prospective cohort study. / Zandvliet, S.; van Wegen, E.; Campfens, S.; van der Kooij, H.; Kwakkel, G.; Meskers, C.

2019. 88-88 Poster session presented at 3rd Congress on NeuroRehabilitation and Neural Repair 2019, Maastricht, Netherlands.

Research output: Contribution to conferencePosterAcademic

TY - CONF

T1 - Position-cortical coherence as a marker for somatosensory integrity early post-stroke, a prospective cohort study

AU - Zandvliet, S.

AU - van Wegen, E.

AU - Campfens, S.

AU - van der Kooij, H.

AU - Kwakkel, G.

AU - Meskers, C.

PY - 2019/5/22

Y1 - 2019/5/22

N2 - Introduction: Neurophysiological assessments in addition to clinical scales can potentially elucidate the role of somatosensory function in post-stroke motor recovery. Main objective:To investigate the longitudinal construct validity of positioncortical coherence (PCC), the agreement between evoked wrist perturbations and EEG, as a measure of afferent integrity, with respect to longitudinal recovery of sensorimotor function. Methods: PCC was measured serially in 48 patients after a fi rst-ever ischemic stroke, in addition to Fugl-Meyer motor assessment of the upper extremity (FM-UE) and Erasmus modifi cation of the Nottingham Sensory Assessment (EmNSA), within 3, 5, 12 and 26 weeks post-stroke. Change in PCC over time represented by: percentage presence of PCC (%PCC), mean amplitude of PCC over the affected hemisphere (Amp-A) were addressed as well as their association with FM-UE and EmNSA. Patients were classifi ed into: expectedfi tters (FM-UE-baseline=18 points), unexpected-fi tters (FM-UE-baseline<18 points) and non-fi tters (FM-UE-baseline<18 points), to the proportional recovery model. Results and discussion: %PCC increased from baseline to 12 weeks post-stroke (ß:1.6%, CI:0.32-2.86%, P=0.01), which was no longer signifi cant after adjusting for EmNSA and FM-UE. A signifi cant positive association was found between %PCC, Amp-A and EmNSA. Unexpected fi tters (N=8) showed longitudinally signifi cantly higher %PCC than those expected to fi t the proportional recovery model (N=23). Conclusion: We demonstrated the longitudinal construct validity of %PCC and Amp-A as a measure of afferent pathway integrity. A high %PCC in unexpected fi tters suggests that this marker contains information above afferent integrity, i.e. cortical excitability. More work is needed to improve clinical prediction models for functional outcome post-stroke.

AB - Introduction: Neurophysiological assessments in addition to clinical scales can potentially elucidate the role of somatosensory function in post-stroke motor recovery. Main objective:To investigate the longitudinal construct validity of positioncortical coherence (PCC), the agreement between evoked wrist perturbations and EEG, as a measure of afferent integrity, with respect to longitudinal recovery of sensorimotor function. Methods: PCC was measured serially in 48 patients after a fi rst-ever ischemic stroke, in addition to Fugl-Meyer motor assessment of the upper extremity (FM-UE) and Erasmus modifi cation of the Nottingham Sensory Assessment (EmNSA), within 3, 5, 12 and 26 weeks post-stroke. Change in PCC over time represented by: percentage presence of PCC (%PCC), mean amplitude of PCC over the affected hemisphere (Amp-A) were addressed as well as their association with FM-UE and EmNSA. Patients were classifi ed into: expectedfi tters (FM-UE-baseline=18 points), unexpected-fi tters (FM-UE-baseline<18 points) and non-fi tters (FM-UE-baseline<18 points), to the proportional recovery model. Results and discussion: %PCC increased from baseline to 12 weeks post-stroke (ß:1.6%, CI:0.32-2.86%, P=0.01), which was no longer signifi cant after adjusting for EmNSA and FM-UE. A signifi cant positive association was found between %PCC, Amp-A and EmNSA. Unexpected fi tters (N=8) showed longitudinally signifi cantly higher %PCC than those expected to fi t the proportional recovery model (N=23). Conclusion: We demonstrated the longitudinal construct validity of %PCC and Amp-A as a measure of afferent pathway integrity. A high %PCC in unexpected fi tters suggests that this marker contains information above afferent integrity, i.e. cortical excitability. More work is needed to improve clinical prediction models for functional outcome post-stroke.

M3 - Poster

SP - 88

EP - 88

ER -

Zandvliet S, van Wegen E, Campfens S, van der Kooij H, Kwakkel G, Meskers C. Position-cortical coherence as a marker for somatosensory integrity early post-stroke, a prospective cohort study. 2019. Poster session presented at 3rd Congress on NeuroRehabilitation and Neural Repair 2019, Maastricht, Netherlands.