Position-cortical coherence as a marker for somatosensory integrity early post-stroke, a prospective cohort study

S. Zandvliet, E. van Wegen, S. Campfens, H. van der Kooij, G. Kwakkel, C. Meskers

    Research output: Contribution to conferencePosterAcademic

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    Abstract

    Introduction: Neurophysiological assessments in addition to clinical scales can potentially elucidate the role of somatosensory function in post-stroke motor recovery. Main objective:To investigate the longitudinal construct validity of positioncortical coherence (PCC), the agreement between evoked wrist perturbations and EEG, as a measure of afferent integrity, with respect to longitudinal recovery of sensorimotor function. Methods: PCC was measured serially in 48 patients after a fi rst-ever ischemic stroke, in addition to Fugl-Meyer motor assessment of the upper extremity (FM-UE) and Erasmus modifi cation of the Nottingham Sensory Assessment (EmNSA), within 3, 5, 12 and 26 weeks post-stroke. Change in PCC over time represented by: percentage presence of PCC (%PCC), mean amplitude of PCC over the affected hemisphere (Amp-A) were addressed as well as their association with FM-UE and EmNSA. Patients were classifi ed into: expectedfi tters (FM-UE-baseline=18 points), unexpected-fi tters (FM-UE-baseline<18 points) and non-fi tters (FM-UE-baseline<18 points), to the proportional recovery model. Results and discussion: %PCC increased from baseline to 12 weeks post-stroke (ß:1.6%, CI:0.32-2.86%, P=0.01), which was no longer signifi cant after adjusting for EmNSA and FM-UE. A signifi cant positive association was found between %PCC, Amp-A and EmNSA. Unexpected fi tters (N=8) showed longitudinally signifi cantly higher %PCC than those expected to fi t the proportional recovery model (N=23). Conclusion: We demonstrated the longitudinal construct validity of %PCC and Amp-A as a measure of afferent pathway integrity. A high %PCC in unexpected fi tters suggests that this marker contains information above afferent integrity, i.e. cortical excitability. More work is needed to improve clinical prediction models for functional outcome post-stroke.
    Original languageEnglish
    Pages88-88
    Number of pages1
    Publication statusPublished - 22 May 2019
    Event3rd Congress on NeuroRehabilitation and Neural Repair 2019 - Maastricht, Netherlands
    Duration: 22 May 201924 May 2019
    Conference number: 3

    Conference

    Conference3rd Congress on NeuroRehabilitation and Neural Repair 2019
    CountryNetherlands
    CityMaastricht
    Period22/05/1924/05/19

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