Posterior tibial nerve somatosensory evoked potentials in slowly progressive spastic paraplegia: a comparative study with clinical signs

C.M. Aalfs, J.H.T.M. Koelman, M. Aramideh, L.J. Bour, R.P.M. Bruyn, B.W. Ongerboer de Visser*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Clinical and neurophysiological examinations were performed on seven patients with hereditary spastic paraplegia and on eight patients with primary lateral
sclerosis. The results were compared with those obtained from a group of 39 control subjects. Prolonged latency times and decreased amplitudes of the posterior tibial nerve (PTN) somatosensory evoked potentials (SEPs) were found in the majority of the patients. The SEP changes occurred without sensory impairment or with loss of vibration sense only. There was no significant relation between the PTN SEP abnormalities and the severity of pyramidal signs for the whole patient group, nor longitudinally for the individual subjects. Analyses of PTN SEPs in patients suffering from slowly progressive spastic paraplegia (SP), therefore, seem to be a method to indicate a feature of spinal cord dysfunction that is not related to the severity of clinical signs. Considering the neuropathology of the spinal cord in SP patients, we furthermore argue that the ascending spinal pathway involved in conducting impulses for PTN SEPs probably
uses other routes as well as the funiculus gracilis.
Original languageEnglish
Pages (from-to)351-356
Number of pages6
JournalJournal of neurology
Volume240
Issue number6
DOIs
Publication statusPublished - 1 Jun 1993
Externally publishedYes

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