Postmortem histopathology of electroencephalography and evoked potentials in postanoxic coma

Michel J.A.M. van Putten* (Corresponding Author), Casper Jansen, Marleen C. Tjepkema-Cloostermans, Tim M.J. Beernink, Rob Koot, Frank Bos, Albertus Beishuizen, Jeannette Hofmeijer

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

25 Citations (Scopus)
34 Downloads (Pure)


Early EEG patterns and SSEP responses are associated with neurological recovery of comatose patients with postanoxic encephalopathy after cardiac arrest. However, the nature and distribution of brain damage underlying the characteristic EEG and SSEP patterns are unknown. We relate EEG and SSEP findings with results from histological analyses of the brains of eleven non-survivors. With restoration towards continuous rhythms within 24 h after cardiac arrest, no signs of structural neuronal damage were observed. Absent SSEP responses were always accompanied by thalamic damage.Pathological burst suppression patterns were associated with a variable degree of neuronal damage to cortex, cerebellum and hippocampus. In patients with additional thalamic involvement, burst-suppression with identical bursts was observed, a characteristic EEG pattern presumably reflecting residual activity from a relatively isolated and severely compromised cortex.
Original languageEnglish
Pages (from-to)26-32
Number of pages7
Publication statusPublished - 1 Jan 2019


  • UT-Hybrid-D
  • Postanoxic coma
  • Postmortem histopathology
  • Prognostication
  • SSEP
  • EEG


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