TY - JOUR
T1 - Postmortem histopathology of electroencephalography and evoked potentials in postanoxic coma
AU - van Putten, Michel J.A.M.
AU - Jansen, Casper
AU - Tjepkema-Cloostermans, Marleen C.
AU - Beernink, Tim M.J.
AU - Koot, Rob
AU - Bos, Frank
AU - Beishuizen, Albertus
AU - Hofmeijer, Jeannette
N1 - Elsevier deal
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Early EEG patterns and SSEP responses are associated with neurological recovery of comatose patients with postanoxic encephalopathy after cardiac arrest. However, the nature and distribution of brain damage underlying the characteristic EEG and SSEP patterns are unknown. We relate EEG and SSEP findings with results from histological analyses of the brains of eleven non-survivors. With restoration towards continuous rhythms within 24 h after cardiac arrest, no signs of structural neuronal damage were observed. Absent SSEP responses were always accompanied by thalamic damage.Pathological burst suppression patterns were associated with a variable degree of neuronal damage to cortex, cerebellum and hippocampus. In patients with additional thalamic involvement, burst-suppression with identical bursts was observed, a characteristic EEG pattern presumably reflecting residual activity from a relatively isolated and severely compromised cortex.
AB - Early EEG patterns and SSEP responses are associated with neurological recovery of comatose patients with postanoxic encephalopathy after cardiac arrest. However, the nature and distribution of brain damage underlying the characteristic EEG and SSEP patterns are unknown. We relate EEG and SSEP findings with results from histological analyses of the brains of eleven non-survivors. With restoration towards continuous rhythms within 24 h after cardiac arrest, no signs of structural neuronal damage were observed. Absent SSEP responses were always accompanied by thalamic damage.Pathological burst suppression patterns were associated with a variable degree of neuronal damage to cortex, cerebellum and hippocampus. In patients with additional thalamic involvement, burst-suppression with identical bursts was observed, a characteristic EEG pattern presumably reflecting residual activity from a relatively isolated and severely compromised cortex.
KW - UT-Hybrid-D
KW - Postanoxic coma
KW - Postmortem histopathology
KW - Prognostication
KW - SSEP
KW - EEG
UR - http://www.scopus.com/inward/record.url?scp=85059690463&partnerID=8YFLogxK
U2 - 10.1016/j.resuscitation.2018.12.007
DO - 10.1016/j.resuscitation.2018.12.007
M3 - Article
VL - 134
SP - 26
EP - 32
JO - Resuscitation
JF - Resuscitation
SN - 0300-9572
ER -