Potential Health and Environmental Risks of Three-Dimensional Engineered Polymers

Marcia de Almeida Monteiro Melo Ferraz, Heiko H.W. Henning, Pedro Ferreira da Costa, Jos Malda, Séverine le Gac, Fabrice Bray, Marjorie B.M. van Duursen, Jos Brouwers, Chris H.A. van de Lest, Ingeborg Bertijn, Lisa Kraneburg, Peter L.A.M. Vos, Tom A.E. Stout, Barend M. Gadella (Corresponding Author)

    Research output: Contribution to journalArticleAcademicpeer-review

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    Abstract

    Polymer engineering, such as in three-dimensional (3D) printing, is rapidly gaining popularity, not only in the scientific and medical fields but also in the community in general. However, little is known about the toxicity of engineered materials. Therefore, we assessed the toxicity of 3D-printed and molded parts from five different polymers commonly used for prototyping, fabrication of organ-on-a-chip platforms, and medical devices. Toxic effects of PIC100, E-Shell200, E-Shell300, polydimethylsiloxane, and polystyrene (PS) on early bovine embryo development, on the transactivation of estrogen receptors were assessed, and possible polymer-leached components were identified by mass spectrometry. Embryo development beyond the two-cell stage was inhibited by PIC100, E-Shell200, and E-Shell300 and correlated to the released amount of diethyl phthalate and polyethylene glycol. Furthermore, all polymers (except PS) induced estrogen receptor transactivation. The released materials from PIC100 inhibited embryo cleavage across a confluent monolayer culture of oviduct epithelial cells and also inhibited oocyte maturation. These findings highlight the need for cautious use of engineered polymers for household 3D printing and bioengineering of culture and medical devices and the need for the safe disposal of used devices and associated waste.
    Original languageEnglish
    Pages (from-to)80-85
    Number of pages6
    JournalEnvironmental science & technology letters
    Volume5
    Issue number2
    DOIs
    Publication statusPublished - 5 Jan 2018

    Fingerprint

    Environmental Health
    environmental risk
    health risk
    Polymers
    polymer
    Health
    embryo
    Polystyrenes
    Estrogen Receptors
    Equipment and Supplies
    Transcriptional Activation
    Embryonic Development
    Toxicity
    Printing
    toxicity
    bioengineering
    Bioengineering
    Oviducts
    Poisons
    phthalate

    Keywords

    • UT-Hybrid-D

    Cite this

    de Almeida Monteiro Melo Ferraz, M., Henning, H. H. W., Ferreira da Costa, P., Malda, J., le Gac, S., Bray, F., ... Gadella, B. M. (2018). Potential Health and Environmental Risks of Three-Dimensional Engineered Polymers. Environmental science & technology letters, 5(2), 80-85. https://doi.org/10.1021/acs.estlett.7b00495
    de Almeida Monteiro Melo Ferraz, Marcia ; Henning, Heiko H.W. ; Ferreira da Costa, Pedro ; Malda, Jos ; le Gac, Séverine ; Bray, Fabrice ; van Duursen, Marjorie B.M. ; Brouwers, Jos ; van de Lest, Chris H.A. ; Bertijn, Ingeborg ; Kraneburg, Lisa ; Vos, Peter L.A.M. ; Stout, Tom A.E. ; Gadella, Barend M. / Potential Health and Environmental Risks of Three-Dimensional Engineered Polymers. In: Environmental science & technology letters. 2018 ; Vol. 5, No. 2. pp. 80-85.
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    abstract = "Polymer engineering, such as in three-dimensional (3D) printing, is rapidly gaining popularity, not only in the scientific and medical fields but also in the community in general. However, little is known about the toxicity of engineered materials. Therefore, we assessed the toxicity of 3D-printed and molded parts from five different polymers commonly used for prototyping, fabrication of organ-on-a-chip platforms, and medical devices. Toxic effects of PIC100, E-Shell200, E-Shell300, polydimethylsiloxane, and polystyrene (PS) on early bovine embryo development, on the transactivation of estrogen receptors were assessed, and possible polymer-leached components were identified by mass spectrometry. Embryo development beyond the two-cell stage was inhibited by PIC100, E-Shell200, and E-Shell300 and correlated to the released amount of diethyl phthalate and polyethylene glycol. Furthermore, all polymers (except PS) induced estrogen receptor transactivation. The released materials from PIC100 inhibited embryo cleavage across a confluent monolayer culture of oviduct epithelial cells and also inhibited oocyte maturation. These findings highlight the need for cautious use of engineered polymers for household 3D printing and bioengineering of culture and medical devices and the need for the safe disposal of used devices and associated waste.",
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    de Almeida Monteiro Melo Ferraz, M, Henning, HHW, Ferreira da Costa, P, Malda, J, le Gac, S, Bray, F, van Duursen, MBM, Brouwers, J, van de Lest, CHA, Bertijn, I, Kraneburg, L, Vos, PLAM, Stout, TAE & Gadella, BM 2018, 'Potential Health and Environmental Risks of Three-Dimensional Engineered Polymers', Environmental science & technology letters, vol. 5, no. 2, pp. 80-85. https://doi.org/10.1021/acs.estlett.7b00495

    Potential Health and Environmental Risks of Three-Dimensional Engineered Polymers. / de Almeida Monteiro Melo Ferraz, Marcia; Henning, Heiko H.W.; Ferreira da Costa, Pedro; Malda, Jos; le Gac, Séverine; Bray, Fabrice; van Duursen, Marjorie B.M.; Brouwers, Jos; van de Lest, Chris H.A.; Bertijn, Ingeborg; Kraneburg, Lisa; Vos, Peter L.A.M.; Stout, Tom A.E.; Gadella, Barend M. (Corresponding Author).

    In: Environmental science & technology letters, Vol. 5, No. 2, 05.01.2018, p. 80-85.

    Research output: Contribution to journalArticleAcademicpeer-review

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    AU - Malda, Jos

    AU - le Gac, Séverine

    AU - Bray, Fabrice

    AU - van Duursen, Marjorie B.M.

    AU - Brouwers, Jos

    AU - van de Lest, Chris H.A.

    AU - Bertijn, Ingeborg

    AU - Kraneburg, Lisa

    AU - Vos, Peter L.A.M.

    AU - Stout, Tom A.E.

    AU - Gadella, Barend M.

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    N2 - Polymer engineering, such as in three-dimensional (3D) printing, is rapidly gaining popularity, not only in the scientific and medical fields but also in the community in general. However, little is known about the toxicity of engineered materials. Therefore, we assessed the toxicity of 3D-printed and molded parts from five different polymers commonly used for prototyping, fabrication of organ-on-a-chip platforms, and medical devices. Toxic effects of PIC100, E-Shell200, E-Shell300, polydimethylsiloxane, and polystyrene (PS) on early bovine embryo development, on the transactivation of estrogen receptors were assessed, and possible polymer-leached components were identified by mass spectrometry. Embryo development beyond the two-cell stage was inhibited by PIC100, E-Shell200, and E-Shell300 and correlated to the released amount of diethyl phthalate and polyethylene glycol. Furthermore, all polymers (except PS) induced estrogen receptor transactivation. The released materials from PIC100 inhibited embryo cleavage across a confluent monolayer culture of oviduct epithelial cells and also inhibited oocyte maturation. These findings highlight the need for cautious use of engineered polymers for household 3D printing and bioengineering of culture and medical devices and the need for the safe disposal of used devices and associated waste.

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    de Almeida Monteiro Melo Ferraz M, Henning HHW, Ferreira da Costa P, Malda J, le Gac S, Bray F et al. Potential Health and Environmental Risks of Three-Dimensional Engineered Polymers. Environmental science & technology letters. 2018 Jan 5;5(2):80-85. https://doi.org/10.1021/acs.estlett.7b00495