TY - JOUR
T1 - Potential of Contrast-Enhanced Ultrasound as a Bedside Monitoring Technique in Cerebral Perfusion
T2 - a Systematic Review
AU - Vinke, Elisabeth J.
AU - Kortenbout, Anna J.
AU - Eyding, Jens
AU - Slump, Cornelis H.
AU - van der Hoeven, Johannes G.
AU - de Korte, Chris L.
AU - Hoedemaekers, Cornelia W.E.
PY - 2017/12
Y1 - 2017/12
N2 - Contrast-enhanced ultrasound (CEUS) has been suggested as a new method to measure cerebral perfusion in patients with acute brain injury. In this systematic review, the tolerability, repeatability, reproducibility and accuracy of different CEUS techniques for the quantification of cerebral perfusion were assessed. We selected studies published between January 1994 and March 2017 using CEUS to measure cerebral perfusion. We included 43 studies (bolus kinetics n = 31, refill kinetics n = 6, depletion kinetics n = 6) with a total of 861 patients. Tolerability was reported in 28 studies describing 12 patients with mild and transient side effects. Repeatability was assessed in 3 studies, reproducibility in 2 studies and accuracy in 19 studies. Repeatability was high for experienced sonographers and significantly lower for less experienced sonographers. Reproducibility of CEUS was not clear. The sensitivity and specificity of CEUS for the detection of cerebral ischemia ranged from 75% to 96% and from 60% to 100%. Limited data on repeatability, reproducibility and accuracy may suggest that this technique could be feasible for use in acute brain injury patients.
AB - Contrast-enhanced ultrasound (CEUS) has been suggested as a new method to measure cerebral perfusion in patients with acute brain injury. In this systematic review, the tolerability, repeatability, reproducibility and accuracy of different CEUS techniques for the quantification of cerebral perfusion were assessed. We selected studies published between January 1994 and March 2017 using CEUS to measure cerebral perfusion. We included 43 studies (bolus kinetics n = 31, refill kinetics n = 6, depletion kinetics n = 6) with a total of 861 patients. Tolerability was reported in 28 studies describing 12 patients with mild and transient side effects. Repeatability was assessed in 3 studies, reproducibility in 2 studies and accuracy in 19 studies. Repeatability was high for experienced sonographers and significantly lower for less experienced sonographers. Reproducibility of CEUS was not clear. The sensitivity and specificity of CEUS for the detection of cerebral ischemia ranged from 75% to 96% and from 60% to 100%. Limited data on repeatability, reproducibility and accuracy may suggest that this technique could be feasible for use in acute brain injury patients.
KW - Acute brain injury
KW - Cerebral blood flow
KW - Contrast-enhanced ultrasound
KW - Ischemia
KW - Perfusion
KW - 2023 OA procedure
UR - http://www.scopus.com/inward/record.url?scp=85033546510&partnerID=8YFLogxK
U2 - 10.1016/j.ultrasmedbio.2017.08.935
DO - 10.1016/j.ultrasmedbio.2017.08.935
M3 - Review article
AN - SCOPUS:85033546510
SN - 0301-5629
VL - 43
SP - 2751
EP - 2757
JO - Ultrasound in medicine and biology
JF - Ultrasound in medicine and biology
IS - 12
ER -