Potential of Contrast-Enhanced Ultrasound as a Bedside Monitoring Technique in Cerebral Perfusion: a Systematic Review

Elisabeth J. Vinke, Anna J. Kortenbout, Jens Eyding, Cornelis H. Slump, Johannes G. van der Hoeven, Chris L. de Korte, Cornelia W.E. Hoedemaekers

Research output: Contribution to journalReview articleAcademicpeer-review

1 Citation (Scopus)

Abstract

Contrast-enhanced ultrasound (CEUS) has been suggested as a new method to measure cerebral perfusion in patients with acute brain injury. In this systematic review, the tolerability, repeatability, reproducibility and accuracy of different CEUS techniques for the quantification of cerebral perfusion were assessed. We selected studies published between January 1994 and March 2017 using CEUS to measure cerebral perfusion. We included 43 studies (bolus kinetics n = 31, refill kinetics n = 6, depletion kinetics n = 6) with a total of 861 patients. Tolerability was reported in 28 studies describing 12 patients with mild and transient side effects. Repeatability was assessed in 3 studies, reproducibility in 2 studies and accuracy in 19 studies. Repeatability was high for experienced sonographers and significantly lower for less experienced sonographers. Reproducibility of CEUS was not clear. The sensitivity and specificity of CEUS for the detection of cerebral ischemia ranged from 75% to 96% and from 60% to 100%. Limited data on repeatability, reproducibility and accuracy may suggest that this technique could be feasible for use in acute brain injury patients.

Original languageEnglish
Pages (from-to)2751-2757
Number of pages7
JournalUltrasound in medicine and biology
Volume43
Issue number12
DOIs
Publication statusPublished - 1 Dec 2017

Fingerprint

Perfusion
brain damage
Brain Injuries
kinetics
ischemia
Brain Ischemia
depletion
Sensitivity and Specificity
sensitivity

Keywords

  • Acute brain injury
  • Cerebral blood flow
  • Contrast-enhanced ultrasound
  • Ischemia
  • Perfusion

Cite this

Vinke, Elisabeth J. ; Kortenbout, Anna J. ; Eyding, Jens ; Slump, Cornelis H. ; van der Hoeven, Johannes G. ; de Korte, Chris L. ; Hoedemaekers, Cornelia W.E. / Potential of Contrast-Enhanced Ultrasound as a Bedside Monitoring Technique in Cerebral Perfusion : a Systematic Review. In: Ultrasound in medicine and biology. 2017 ; Vol. 43, No. 12. pp. 2751-2757.
@article{dac1ba5ca7b2464f9eceb4e557319c2f,
title = "Potential of Contrast-Enhanced Ultrasound as a Bedside Monitoring Technique in Cerebral Perfusion: a Systematic Review",
abstract = "Contrast-enhanced ultrasound (CEUS) has been suggested as a new method to measure cerebral perfusion in patients with acute brain injury. In this systematic review, the tolerability, repeatability, reproducibility and accuracy of different CEUS techniques for the quantification of cerebral perfusion were assessed. We selected studies published between January 1994 and March 2017 using CEUS to measure cerebral perfusion. We included 43 studies (bolus kinetics n = 31, refill kinetics n = 6, depletion kinetics n = 6) with a total of 861 patients. Tolerability was reported in 28 studies describing 12 patients with mild and transient side effects. Repeatability was assessed in 3 studies, reproducibility in 2 studies and accuracy in 19 studies. Repeatability was high for experienced sonographers and significantly lower for less experienced sonographers. Reproducibility of CEUS was not clear. The sensitivity and specificity of CEUS for the detection of cerebral ischemia ranged from 75{\%} to 96{\%} and from 60{\%} to 100{\%}. Limited data on repeatability, reproducibility and accuracy may suggest that this technique could be feasible for use in acute brain injury patients.",
keywords = "Acute brain injury, Cerebral blood flow, Contrast-enhanced ultrasound, Ischemia, Perfusion",
author = "Vinke, {Elisabeth J.} and Kortenbout, {Anna J.} and Jens Eyding and Slump, {Cornelis H.} and {van der Hoeven}, {Johannes G.} and {de Korte}, {Chris L.} and Hoedemaekers, {Cornelia W.E.}",
year = "2017",
month = "12",
day = "1",
doi = "10.1016/j.ultrasmedbio.2017.08.935",
language = "English",
volume = "43",
pages = "2751--2757",
journal = "Ultrasound in medicine and biology",
issn = "0301-5629",
publisher = "Elsevier",
number = "12",

}

Potential of Contrast-Enhanced Ultrasound as a Bedside Monitoring Technique in Cerebral Perfusion : a Systematic Review. / Vinke, Elisabeth J.; Kortenbout, Anna J.; Eyding, Jens; Slump, Cornelis H.; van der Hoeven, Johannes G.; de Korte, Chris L.; Hoedemaekers, Cornelia W.E.

In: Ultrasound in medicine and biology, Vol. 43, No. 12, 01.12.2017, p. 2751-2757.

Research output: Contribution to journalReview articleAcademicpeer-review

TY - JOUR

T1 - Potential of Contrast-Enhanced Ultrasound as a Bedside Monitoring Technique in Cerebral Perfusion

T2 - a Systematic Review

AU - Vinke, Elisabeth J.

AU - Kortenbout, Anna J.

AU - Eyding, Jens

AU - Slump, Cornelis H.

AU - van der Hoeven, Johannes G.

AU - de Korte, Chris L.

AU - Hoedemaekers, Cornelia W.E.

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Contrast-enhanced ultrasound (CEUS) has been suggested as a new method to measure cerebral perfusion in patients with acute brain injury. In this systematic review, the tolerability, repeatability, reproducibility and accuracy of different CEUS techniques for the quantification of cerebral perfusion were assessed. We selected studies published between January 1994 and March 2017 using CEUS to measure cerebral perfusion. We included 43 studies (bolus kinetics n = 31, refill kinetics n = 6, depletion kinetics n = 6) with a total of 861 patients. Tolerability was reported in 28 studies describing 12 patients with mild and transient side effects. Repeatability was assessed in 3 studies, reproducibility in 2 studies and accuracy in 19 studies. Repeatability was high for experienced sonographers and significantly lower for less experienced sonographers. Reproducibility of CEUS was not clear. The sensitivity and specificity of CEUS for the detection of cerebral ischemia ranged from 75% to 96% and from 60% to 100%. Limited data on repeatability, reproducibility and accuracy may suggest that this technique could be feasible for use in acute brain injury patients.

AB - Contrast-enhanced ultrasound (CEUS) has been suggested as a new method to measure cerebral perfusion in patients with acute brain injury. In this systematic review, the tolerability, repeatability, reproducibility and accuracy of different CEUS techniques for the quantification of cerebral perfusion were assessed. We selected studies published between January 1994 and March 2017 using CEUS to measure cerebral perfusion. We included 43 studies (bolus kinetics n = 31, refill kinetics n = 6, depletion kinetics n = 6) with a total of 861 patients. Tolerability was reported in 28 studies describing 12 patients with mild and transient side effects. Repeatability was assessed in 3 studies, reproducibility in 2 studies and accuracy in 19 studies. Repeatability was high for experienced sonographers and significantly lower for less experienced sonographers. Reproducibility of CEUS was not clear. The sensitivity and specificity of CEUS for the detection of cerebral ischemia ranged from 75% to 96% and from 60% to 100%. Limited data on repeatability, reproducibility and accuracy may suggest that this technique could be feasible for use in acute brain injury patients.

KW - Acute brain injury

KW - Cerebral blood flow

KW - Contrast-enhanced ultrasound

KW - Ischemia

KW - Perfusion

UR - http://www.scopus.com/inward/record.url?scp=85033546510&partnerID=8YFLogxK

U2 - 10.1016/j.ultrasmedbio.2017.08.935

DO - 10.1016/j.ultrasmedbio.2017.08.935

M3 - Review article

VL - 43

SP - 2751

EP - 2757

JO - Ultrasound in medicine and biology

JF - Ultrasound in medicine and biology

SN - 0301-5629

IS - 12

ER -