Practice research in the field of gout: clinical pharmacology of antihyperuricemic drugs

Mattheus Karsien Reinders

Research output: ThesisPhD Thesis - Research external, graduation external

73 Downloads (Pure)

Abstract

Numerous publications identify that gout management is often sub-optimal, despite detailed understanding of the pathogenesis and pathophysiology of the disorder, the ability to establish the diagnosis with certainty, and the likely effectiveness of lifestyle and pharmacological interventions. Barriers to successful gout management include diagnostic inaccuracy, a paucity of guidelines, sub-optimal patient education and patient adherence, co-morbidities and drug-drug interferences that complicate treatment of gout, and limited urate-lowering alternatives. Furthermore, a lack of information exists on the risk-benefit ratios of antihyperuricemic drugs for gout treatment.
This thesis studies the clinical pharmacology of antihyperuricemic dugs in the treatment of gout in clinical practice, with focus on efficacy and tolerability. Studies and reviews of this thesis focus on: management of gout, outcome research with antihyperuricemic drugs, therapeutic drug monitoring of allopurinol, and rasburicase for treatment of gout.
Original languageEnglish
Awarding Institution
  • University of Groningen
Supervisors/Advisors
  • Brouwers, Jacobus R.B.J., Supervisor, External person
  • van de Laar, Mart A.F.J., Supervisor
  • Jansen, T.L.Th.A., Co-Supervisor, External person
  • van Roon, Eric N., Co-Supervisor, External person
Award date28 Nov 2008
Place of PublicationGroningen
Publisher
Print ISBNs978-90-367-3614-5
Publication statusPublished - 28 Nov 2008
Externally publishedYes

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