Prediction from polygenic scores based on GWA of neuroticism to psychiatric and lifestyle traits

Dorret Boomsma; Stéphanie Martine van den Berg; Abdel Abdellaoui; Eco J.C. de Geus; Gonneke Willemsen; Jouke-Jan Hottenga; Christel Middeldorp; Yuri Milaneschi; Michel Nivard; Jacqueline Vink; Meike Bartels; Gerard van Grootheest; Brenda W.J.H. Penninx; Marleen de Moor

doi:10.1007/s10519-015-9742-6

Prediction from polygenic scores based on GWA of neuroticism to psychiatric and lifestyle traits

Dorret Boomsma, Stéphanie Martine van den Berg, Abdel Abdellaoui, Eco J.C. de Geus, Gonneke Willemsen, Jouke-Jan Hottenga, Christel Middeldorp, Yuri Milaneschi, Michel Nivard, Jacqueline Vink, Meike Bartels, Gerard van Grootheest, Brenda W.J.H. Penninx, Marleen de Moor

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Abstract

The first genetic variants associated with neuroticism were identified in a meta-analysis of genome-wide association (GWA) results based on 1000Genomes imputation in 63,661 participants from 29 discovery cohorts and 9786 participants from a replication cohort. Participants came from Europe, the United States or Australia (Van den Berg et al. Behav Genet 2014; de Moor et al. in press). Polygenic scores based on the meta-analysis of neuroticism in 27 cohorts (removing data from NTR and NESDA) significantly predicted neuroticism and MDD in NTR and NESDA. Here we extend the polygenic score prediction to other traits hypothesized to show genetic overlap with a higher neuroticism (anxiety, borderline personality disorder, migraine, smoking), with lower neuroticism (e.g. exercise) or to be independent of neuroticism (other NEO personality traits, alcohol use).

Original language	English
Pages (from-to)	644-
Journal	Behavior genetics
Volume	45
Issue number	6
DOIs	https://doi.org/10.1007/s10519-015-9742-6
Publication status	Published - 2015

Keywords

METIS-313772
IR-98637

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Boomsma, D., van den Berg, S. M., Abdellaoui, A., de Geus, E. J. C., Willemsen, G., Hottenga, J-J., Middeldorp, C., Milaneschi, Y., Nivard, M., Vink, J., Bartels, M., van Grootheest, G., Penninx, B. W. J. H., & de Moor, M. (2015). Prediction from polygenic scores based on GWA of neuroticism to psychiatric and lifestyle traits. Behavior genetics, 45(6), 644-. https://doi.org/10.1007/s10519-015-9742-6

Boomsma, Dorret ; van den Berg, Stéphanie Martine ; Abdellaoui, Abdel ; de Geus, Eco J.C. ; Willemsen, Gonneke ; Hottenga, Jouke-Jan ; Middeldorp, Christel ; Milaneschi, Yuri ; Nivard, Michel ; Vink, Jacqueline ; Bartels, Meike ; van Grootheest, Gerard ; Penninx, Brenda W.J.H. ; de Moor, Marleen. / Prediction from polygenic scores based on GWA of neuroticism to psychiatric and lifestyle traits. In: Behavior genetics. 2015 ; Vol. 45, No. 6. pp. 644-.

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abstract = "The first genetic variants associated with neuroticism were identified in a meta-analysis of genome-wide association (GWA) results based on 1000Genomes imputation in 63,661 participants from 29 discovery cohorts and 9786 participants from a replication cohort. Participants came from Europe, the United States or Australia (Van den Berg et al. Behav Genet 2014; de Moor et al. in press). Polygenic scores based on the meta-analysis of neuroticism in 27 cohorts (removing data from NTR and NESDA) significantly predicted neuroticism and MDD in NTR and NESDA. Here we extend the polygenic score prediction to other traits hypothesized to show genetic overlap with a higher neuroticism (anxiety, borderline personality disorder, migraine, smoking), with lower neuroticism (e.g. exercise) or to be independent of neuroticism (other NEO personality traits, alcohol use).",

keywords = "METIS-313772, IR-98637",

author = "Dorret Boomsma and {van den Berg}, {St{\'e}phanie Martine} and Abdel Abdellaoui and {de Geus}, {Eco J.C.} and Gonneke Willemsen and Jouke-Jan Hottenga and Christel Middeldorp and Yuri Milaneschi and Michel Nivard and Jacqueline Vink and Meike Bartels and {van Grootheest}, Gerard and Penninx, {Brenda W.J.H.} and {de Moor}, Marleen",

note = "Behavior Genetics Association 45th Annual Meeting Abstracts ",

year = "2015",

doi = "10.1007/s10519-015-9742-6",

language = "English",

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Boomsma, D, van den Berg, SM, Abdellaoui, A, de Geus, EJC, Willemsen, G, Hottenga, J-J, Middeldorp, C, Milaneschi, Y, Nivard, M, Vink, J, Bartels, M, van Grootheest, G, Penninx, BWJH & de Moor, M 2015, 'Prediction from polygenic scores based on GWA of neuroticism to psychiatric and lifestyle traits', Behavior genetics, vol. 45, no. 6, pp. 644-. https://doi.org/10.1007/s10519-015-9742-6

Prediction from polygenic scores based on GWA of neuroticism to psychiatric and lifestyle traits. / Boomsma, Dorret; van den Berg, Stéphanie Martine; Abdellaoui, Abdel; de Geus, Eco J.C.; Willemsen, Gonneke; Hottenga, Jouke-Jan; Middeldorp, Christel; Milaneschi, Yuri; Nivard, Michel; Vink, Jacqueline; Bartels, Meike; van Grootheest, Gerard; Penninx, Brenda W.J.H.; de Moor, Marleen.

In: Behavior genetics, Vol. 45, No. 6, 2015, p. 644-.

Research output: Contribution to journal › Article › Academic

TY - JOUR

T1 - Prediction from polygenic scores based on GWA of neuroticism to psychiatric and lifestyle traits

AU - Boomsma, Dorret

AU - van den Berg, Stéphanie Martine

AU - Abdellaoui, Abdel

AU - de Geus, Eco J.C.

AU - Willemsen, Gonneke

AU - Hottenga, Jouke-Jan

AU - Middeldorp, Christel

AU - Milaneschi, Yuri

AU - Nivard, Michel

AU - Vink, Jacqueline

AU - Bartels, Meike

AU - van Grootheest, Gerard

AU - Penninx, Brenda W.J.H.

AU - de Moor, Marleen

N1 - Behavior Genetics Association 45th Annual Meeting Abstracts

PY - 2015

Y1 - 2015

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AB - The first genetic variants associated with neuroticism were identified in a meta-analysis of genome-wide association (GWA) results based on 1000Genomes imputation in 63,661 participants from 29 discovery cohorts and 9786 participants from a replication cohort. Participants came from Europe, the United States or Australia (Van den Berg et al. Behav Genet 2014; de Moor et al. in press). Polygenic scores based on the meta-analysis of neuroticism in 27 cohorts (removing data from NTR and NESDA) significantly predicted neuroticism and MDD in NTR and NESDA. Here we extend the polygenic score prediction to other traits hypothesized to show genetic overlap with a higher neuroticism (anxiety, borderline personality disorder, migraine, smoking), with lower neuroticism (e.g. exercise) or to be independent of neuroticism (other NEO personality traits, alcohol use).

KW - METIS-313772

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DO - 10.1007/s10519-015-9742-6

M3 - Article

VL - 45

SP - 644-

JO - Behavior genetics

JF - Behavior genetics

SN - 0001-8244

IS - 6

ER -

Prediction from polygenic scores based on GWA of neuroticism to psychiatric and lifestyle traits

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Keywords

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