Prediction from polygenic scores based on GWA of neuroticism to psychiatric and lifestyle traits

Dorret Boomsma; Stéphanie van den Berg; Abdel Abdellaoui; Eco de Geus; Gonneke Willemsen; Jouke-Jan Hottenga; Christel Middeldorp; Yuri Milaneschi; Michel Nivard; Jacqueline Vink; Meike Bartels; Gerard van Grootheest; Brenda Penninx; Marleen de Moor

doi:10.1007/s10519-015-9742-6

Prediction from polygenic scores based on GWA of neuroticism to psychiatric and lifestyle traits

Dorret Boomsma, Stéphanie van den Berg, Abdel Abdellaoui, Eco de Geus, Gonneke Willemsen, Jouke-Jan Hottenga, Christel Middeldorp, Yuri Milaneschi, Michel Nivard, Jacqueline Vink, Meike Bartels, Gerard van Grootheest, Brenda Penninx, Marleen de Moor

Faculty of Behavioural, Management and Social Sciences

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

The first genetic variants associated with neuroticism were identified in a meta-analysis of genome-wide association (GWA) results based on 1000Genomes imputation in 63,661 participants from 29 discovery cohorts and 9786 participants from a replication cohort. Participants came from Europe, the United States or Australia (Van den Berg et al. Behav Genet 2014; de Moor et al. in press). Polygenic scores based on the meta-analysis of neuroticism in 27 cohorts (removing data from NTR and NESDA) significantly predicted neuroticism and MDD in NTR and NESDA. Here we extend the polygenic score prediction to other traits hypothesized to show genetic overlap with a higher neuroticism (anxiety, borderline personality disorder, migraine, smoking), with lower neuroticism (e.g. exercise) or to be independent of neuroticism (other NEO personality traits, alcohol use).

Original language	English
Pages (from-to)	644-644
Number of pages	1
Journal	Behavior genetics
Volume	45
Issue number	6
DOIs	https://doi.org/10.1007/s10519-015-9742-6
Publication status	E-pub ahead of print/First online - 6 Oct 2015
Event	45th Annual Meeting of the Behavior Genetics Association 2015 - San Diego, United States Duration: 17 Jun 2015 → 20 Jun 2015 Conference number: 45

Keywords

Borderline Personality Disorder
Twin Pair
Marital Quality
Polygenic Risk Score
Smoking During Pregnancy
2023 OA procedure

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10.1007/s10519-015-9742-6

AbstractFinal published version, 59.9 KBLicence: Taverne

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Boomsma, D., van den Berg, S., Abdellaoui, A., de Geus, E., Willemsen, G., Hottenga, J.-J., Middeldorp, C., Milaneschi, Y., Nivard, M., Vink, J., Bartels, M., van Grootheest, G., Penninx, B., & de Moor, M. (2015). Prediction from polygenic scores based on GWA of neuroticism to psychiatric and lifestyle traits. Behavior genetics, 45(6), 644-644. Advance online publication. https://doi.org/10.1007/s10519-015-9742-6

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abstract = "The first genetic variants associated with neuroticism were identified in a meta-analysis of genome-wide association (GWA) results based on 1000Genomes imputation in 63,661 participants from 29 discovery cohorts and 9786 participants from a replication cohort. Participants came from Europe, the United States or Australia (Van den Berg et al. Behav Genet 2014; de Moor et al. in press). Polygenic scores based on the meta-analysis of neuroticism in 27 cohorts (removing data from NTR and NESDA) significantly predicted neuroticism and MDD in NTR and NESDA. Here we extend the polygenic score prediction to other traits hypothesized to show genetic overlap with a higher neuroticism (anxiety, borderline personality disorder, migraine, smoking), with lower neuroticism (e.g. exercise) or to be independent of neuroticism (other NEO personality traits, alcohol use).",

keywords = "Borderline Personality Disorder, Twin Pair, Marital Quality, Polygenic Risk Score, Smoking During Pregnancy, 2023 OA procedure",

author = "Dorret Boomsma and {van den Berg}, St{\'e}phanie and Abdel Abdellaoui and {de Geus}, Eco and Gonneke Willemsen and Jouke-Jan Hottenga and Christel Middeldorp and Yuri Milaneschi and Michel Nivard and Jacqueline Vink and Meike Bartels and {van Grootheest}, Gerard and Brenda Penninx and {de Moor}, Marleen",

note = "Behavior Genetics Association 45th Annual Meeting Abstracts ; 45th Annual Meeting of the Behavior Genetics Association 2015, BGA ; Conference date: 17-06-2015 Through 20-06-2015",

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Boomsma, D, van den Berg, S, Abdellaoui, A, de Geus, E, Willemsen, G, Hottenga, J-J, Middeldorp, C, Milaneschi, Y, Nivard, M, Vink, J, Bartels, M, van Grootheest, G, Penninx, B & de Moor, M 2015, 'Prediction from polygenic scores based on GWA of neuroticism to psychiatric and lifestyle traits', Behavior genetics, vol. 45, no. 6, pp. 644-644. https://doi.org/10.1007/s10519-015-9742-6

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AU - Boomsma, Dorret

AU - van den Berg, Stéphanie

AU - Abdellaoui, Abdel

AU - de Geus, Eco

AU - Willemsen, Gonneke

AU - Hottenga, Jouke-Jan

AU - Middeldorp, Christel

AU - Milaneschi, Yuri

AU - Nivard, Michel

AU - Vink, Jacqueline

AU - Bartels, Meike

AU - van Grootheest, Gerard

AU - Penninx, Brenda

AU - de Moor, Marleen

N1 - Conference code: 45

PY - 2015/10/6

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AB - The first genetic variants associated with neuroticism were identified in a meta-analysis of genome-wide association (GWA) results based on 1000Genomes imputation in 63,661 participants from 29 discovery cohorts and 9786 participants from a replication cohort. Participants came from Europe, the United States or Australia (Van den Berg et al. Behav Genet 2014; de Moor et al. in press). Polygenic scores based on the meta-analysis of neuroticism in 27 cohorts (removing data from NTR and NESDA) significantly predicted neuroticism and MDD in NTR and NESDA. Here we extend the polygenic score prediction to other traits hypothesized to show genetic overlap with a higher neuroticism (anxiety, borderline personality disorder, migraine, smoking), with lower neuroticism (e.g. exercise) or to be independent of neuroticism (other NEO personality traits, alcohol use).

KW - Borderline Personality Disorder

KW - Twin Pair

KW - Marital Quality

KW - Polygenic Risk Score

KW - Smoking During Pregnancy

KW - 2023 OA procedure

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DO - 10.1007/s10519-015-9742-6

M3 - Article

SN - 0001-8244

VL - 45

SP - 644

EP - 644

JO - Behavior genetics

JF - Behavior genetics

IS - 6

T2 - 45th Annual Meeting of the Behavior Genetics Association 2015

Y2 - 17 June 2015 through 20 June 2015

ER -

Prediction from polygenic scores based on GWA of neuroticism to psychiatric and lifestyle traits

Abstract

Keywords

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