Prediction from polygenic scores based on GWA of neuroticism to psychiatric and lifestyle traits

Dorret Boomsma, Stéphanie van den Berg, Abdel Abdellaoui, Eco de Geus, Gonneke Willemsen, Jouke-Jan Hottenga, Christel Middeldorp, Yuri Milaneschi, Michel Nivard, Jacqueline Vink, Meike Bartels, Gerard van Grootheest, Brenda Penninx, Marleen de Moor

Research output: Contribution to journalArticleAcademicpeer-review

143 Downloads (Pure)


The first genetic variants associated with neuroticism were identified in a meta-analysis of genome-wide association (GWA) results based on 1000Genomes imputation in 63,661 participants from 29 discovery cohorts and 9786 participants from a replication cohort. Participants came from Europe, the United States or Australia (Van den Berg et al. Behav Genet 2014; de Moor et al. in press). Polygenic scores based on the meta-analysis of neuroticism in 27 cohorts (removing data from NTR and NESDA) significantly predicted neuroticism and MDD in NTR and NESDA. Here we extend the polygenic score prediction to other traits hypothesized to show genetic overlap with a higher neuroticism (anxiety, borderline personality disorder, migraine, smoking), with lower neuroticism (e.g. exercise) or to be independent of neuroticism (other NEO personality traits, alcohol use).
Original languageEnglish
Pages (from-to)644-644
Number of pages1
JournalBehavior genetics
Issue number6
Publication statusE-pub ahead of print/First online - 6 Oct 2015
Event45th Annual Meeting of the Behavior Genetics Association 2015 - San Diego, United States
Duration: 17 Jun 201520 Jun 2015
Conference number: 45


  • Borderline Personality Disorder
  • Twin Pair
  • Marital Quality
  • Polygenic Risk Score
  • Smoking During Pregnancy
  • 2023 OA procedure


Dive into the research topics of 'Prediction from polygenic scores based on GWA of neuroticism to psychiatric and lifestyle traits'. Together they form a unique fingerprint.

Cite this