Predictive value of in vitro and in vivo assays in bone and cartilage repair - What do they really tell us about the clinical performance?

Pamela Habibovic, John P. Fisher (Editor), T.B.F. Woodfield, K. de Groot, Clemens van Blitterswijk

Research output: Contribution to journalArticleAcademicpeer-review

27 Citations (Scopus)

Abstract

The continuous increase of life expectancy leads to an expanding demand for repair and replacement of damaged and degraded organs and tissues. Recent completion of a first version of the human genome sequence is a great breakthrough for the field of pharmaceutics. It is conceivable that new developments in pharmaceutical research will result in a large number of novel and improved medicines. A similar development is expected in the field of biomaterials designed for bone and cartilage repair and replacement. Spinal fusions and repairs of bone defects caused by trauma, tumors, infections, biochemical disorders and abnormal skeletal development, are some examples of the frequently performed surgeries in the clinic. For most of these surgeries, there is a great need for bone graft substitutes. Similarly, the number of patients worldwide experiencing joint pain and loss of mobility through trauma or degenerative cartilage conditions is considerable, and yet, few approaches employed clinically are capable of restoring long-term function to damaged articular cartilage1, 2. Therefore, new materials and techniques need to be developed.
Original languageUndefined
Pages (from-to)327-360
JournalTissue engineering
Volume585
DOIs
Publication statusPublished - 2006

Keywords

  • IR-67205
  • METIS-236650

Cite this

Habibovic, Pamela ; Fisher, John P. (Editor) ; Woodfield, T.B.F. ; de Groot, K. ; van Blitterswijk, Clemens. / Predictive value of in vitro and in vivo assays in bone and cartilage repair - What do they really tell us about the clinical performance?. In: Tissue engineering. 2006 ; Vol. 585. pp. 327-360.
@article{d6dcefabc4784036880762f7f2697cf3,
title = "Predictive value of in vitro and in vivo assays in bone and cartilage repair - What do they really tell us about the clinical performance?",
abstract = "The continuous increase of life expectancy leads to an expanding demand for repair and replacement of damaged and degraded organs and tissues. Recent completion of a first version of the human genome sequence is a great breakthrough for the field of pharmaceutics. It is conceivable that new developments in pharmaceutical research will result in a large number of novel and improved medicines. A similar development is expected in the field of biomaterials designed for bone and cartilage repair and replacement. Spinal fusions and repairs of bone defects caused by trauma, tumors, infections, biochemical disorders and abnormal skeletal development, are some examples of the frequently performed surgeries in the clinic. For most of these surgeries, there is a great need for bone graft substitutes. Similarly, the number of patients worldwide experiencing joint pain and loss of mobility through trauma or degenerative cartilage conditions is considerable, and yet, few approaches employed clinically are capable of restoring long-term function to damaged articular cartilage1, 2. Therefore, new materials and techniques need to be developed.",
keywords = "IR-67205, METIS-236650",
author = "Pamela Habibovic and Fisher, {John P.} and T.B.F. Woodfield and {de Groot}, K. and {van Blitterswijk}, Clemens",
note = "Advances in Experimental Medicine and Biology 585",
year = "2006",
doi = "10.1007/978-0-387-34133-0_22",
language = "Undefined",
volume = "585",
pages = "327--360",
journal = "Tissue engineering",
issn = "1076-3279",
publisher = "Mary Ann Liebert Inc.",

}

Predictive value of in vitro and in vivo assays in bone and cartilage repair - What do they really tell us about the clinical performance? / Habibovic, Pamela; Fisher, John P. (Editor); Woodfield, T.B.F.; de Groot, K.; van Blitterswijk, Clemens.

In: Tissue engineering, Vol. 585, 2006, p. 327-360.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Predictive value of in vitro and in vivo assays in bone and cartilage repair - What do they really tell us about the clinical performance?

AU - Habibovic, Pamela

AU - Woodfield, T.B.F.

AU - de Groot, K.

AU - van Blitterswijk, Clemens

A2 - Fisher, John P.

N1 - Advances in Experimental Medicine and Biology 585

PY - 2006

Y1 - 2006

N2 - The continuous increase of life expectancy leads to an expanding demand for repair and replacement of damaged and degraded organs and tissues. Recent completion of a first version of the human genome sequence is a great breakthrough for the field of pharmaceutics. It is conceivable that new developments in pharmaceutical research will result in a large number of novel and improved medicines. A similar development is expected in the field of biomaterials designed for bone and cartilage repair and replacement. Spinal fusions and repairs of bone defects caused by trauma, tumors, infections, biochemical disorders and abnormal skeletal development, are some examples of the frequently performed surgeries in the clinic. For most of these surgeries, there is a great need for bone graft substitutes. Similarly, the number of patients worldwide experiencing joint pain and loss of mobility through trauma or degenerative cartilage conditions is considerable, and yet, few approaches employed clinically are capable of restoring long-term function to damaged articular cartilage1, 2. Therefore, new materials and techniques need to be developed.

AB - The continuous increase of life expectancy leads to an expanding demand for repair and replacement of damaged and degraded organs and tissues. Recent completion of a first version of the human genome sequence is a great breakthrough for the field of pharmaceutics. It is conceivable that new developments in pharmaceutical research will result in a large number of novel and improved medicines. A similar development is expected in the field of biomaterials designed for bone and cartilage repair and replacement. Spinal fusions and repairs of bone defects caused by trauma, tumors, infections, biochemical disorders and abnormal skeletal development, are some examples of the frequently performed surgeries in the clinic. For most of these surgeries, there is a great need for bone graft substitutes. Similarly, the number of patients worldwide experiencing joint pain and loss of mobility through trauma or degenerative cartilage conditions is considerable, and yet, few approaches employed clinically are capable of restoring long-term function to damaged articular cartilage1, 2. Therefore, new materials and techniques need to be developed.

KW - IR-67205

KW - METIS-236650

U2 - 10.1007/978-0-387-34133-0_22

DO - 10.1007/978-0-387-34133-0_22

M3 - Article

VL - 585

SP - 327

EP - 360

JO - Tissue engineering

JF - Tissue engineering

SN - 1076-3279

ER -