Prednisolone-containing liposomes accumulate in human atherosclerotic macrophages upon intravenous administration

Fleur M. van der Valk, Diederik F. van Wijk, Mark E. Lobatto, Hein J. Verberne, Gerrit Storm, Martine C.M. Willems, Dink A. Legemate, Aart J. Nederveen, Claudia Calcagno, Venkatesh Mani, Sarayu Ramachandran, Maarten P.M. Paridaans, Maarten J. Otten, Geesje M. Dallinga-Thie, Zahi A. Fayad, Max Nieuwdorp, Dominik M. Schulte, Josbert M. Metselaar, Willem J.M. Mulder, Erik S.G. Stroes

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69 Citations (Scopus)

Abstract

Drug delivery to atherosclerotic plaques via liposomal nanoparticles may improve therapeutic agents’ risk–benefit ratios. Our paper details the first clinical studies of a liposomal nanoparticle encapsulating prednisolone (LN-PLP) in atherosclerosis. First, PLP’s liposomal encapsulation improved its pharmacokinetic profile in humans (n = 13) as attested by an increased plasma half-life of 63 h (LN-PLP 1.5 mg/kg). Second, intravenously infused LN-PLP appeared in 75% of the macrophages isolated from iliofemoral plaques of patients (n = 14) referred for vascular surgery in a randomized, placebo-controlled trial. LN-PLP treatment did however not reduce arterial wall permeability or inflammation in patients with atherosclerotic disease (n = 30), as assessed by multimodal imaging in a subsequent randomized, placebo-controlled study. In conclusion, we successfully delivered a long-circulating nanoparticle to atherosclerotic plaque macrophages in patients, whereas prednisolone accumulation in atherosclerotic lesions had no anti-inflammatory effect. Nonetheless, the present study provides guidance for development and imaging-assisted evaluation of future nanomedicine in atherosclerosis.
Original languageEnglish
Pages (from-to)1039-1046
JournalNanomedicine
Volume11
Issue number5
DOIs
Publication statusPublished - 2015

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    van der Valk, F. M., van Wijk, D. F., Lobatto, M. E., Verberne, H. J., Storm, G., Willems, M. C. M., ... Stroes, E. S. G. (2015). Prednisolone-containing liposomes accumulate in human atherosclerotic macrophages upon intravenous administration. Nanomedicine, 11(5), 1039-1046. https://doi.org/10.1016/j.nano.2015.02.021