Preference, satisfaction and errors with two dry powder inhalers in patients with COPD

Jacobus Adrianus Maria van der Palen, Thomas Ginko, Axel Kroker, Paul van der Valk, Martijn Goosens, Laura Padulles, Beatriz Seoane, Ludmyla Rekeda, Esther Garcia Gil

Research output: Contribution to journalArticleAcademicpeer-review

41 Citations (Scopus)

Abstract

Objective: To assess preference, satisfaction and critical errors with a novel, breath-actuated, multi-dose dry powder inhaler (DPI; Genuair®/Pressair™), versus a widely used, single-dose DPI (HandiHaler®) in patients with moderate-to-severe chronic obstructive pulmonary disease. Methods: In this randomised, open-label, multicentre, cross-over study, patients (aged ≥ 40 years) inhaled placebo once daily through both inhalers for 2 weeks in addition to current medication. The primary end point was percentage of patients who preferred Genuair to HandiHaler. Overall patient satisfaction (5-point scale: 1 = very dissatisfied; 5 = very satisfied), critical errors and willingness to continue using each inhaler (0 = not willing; 100 = definitely willing) were assessed. Results: Of 130 patients randomised, 105 were included in the intent-to-treat population (71.4% male; mean age 65.7 years). After 2 weeks, significantly more patients preferred Genuair than HandiHaler (79.1 vs 20.9%; p < 0.0001). Overall satisfaction scores (4.6 vs 3.8; p < 0.0001) and willingness to continue use scores (84.0 vs 62.5; p < 0.0001) were significantly higher with Genuair versus HandiHaler. Significantly fewer patients made ≥ 1 critical error with Genuair only compared with HandiHaler only (2.9 vs 19.0%; p < 0.0001). Conclusion: After 2 weeks' practice, patients preferred and were more willing to continue using Genuair than HandiHaler. Genuair was associated with higher patient satisfaction and fewer critical errors than HandiHaler Read More: http://informahealthcare.com/doi/abs/10.1517/17425247.2013.808186
Original languageEnglish
Pages (from-to)1023-1031
JournalExpert opinion on drug delivery
Volume10
Issue number8
DOIs
Publication statusPublished - 2013

Fingerprint

Dry Powder Inhalers
Chronic Obstructive Pulmonary Disease
Nebulizers and Vaporizers
Patient Satisfaction
Cross-Over Studies
Placebos

Keywords

  • IR-88746
  • METIS-301159

Cite this

van der Palen, Jacobus Adrianus Maria ; Ginko, Thomas ; Kroker, Axel ; van der Valk, Paul ; Goosens, Martijn ; Padulles, Laura ; Seoane, Beatriz ; Rekeda, Ludmyla ; Garcia Gil, Esther. / Preference, satisfaction and errors with two dry powder inhalers in patients with COPD. In: Expert opinion on drug delivery. 2013 ; Vol. 10, No. 8. pp. 1023-1031.
@article{500fc3baf8b14fd2884c555c1286cdee,
title = "Preference, satisfaction and errors with two dry powder inhalers in patients with COPD",
abstract = "Objective: To assess preference, satisfaction and critical errors with a novel, breath-actuated, multi-dose dry powder inhaler (DPI; Genuair{\circledR}/Pressair™), versus a widely used, single-dose DPI (HandiHaler{\circledR}) in patients with moderate-to-severe chronic obstructive pulmonary disease. Methods: In this randomised, open-label, multicentre, cross-over study, patients (aged ≥ 40 years) inhaled placebo once daily through both inhalers for 2 weeks in addition to current medication. The primary end point was percentage of patients who preferred Genuair to HandiHaler. Overall patient satisfaction (5-point scale: 1 = very dissatisfied; 5 = very satisfied), critical errors and willingness to continue using each inhaler (0 = not willing; 100 = definitely willing) were assessed. Results: Of 130 patients randomised, 105 were included in the intent-to-treat population (71.4{\%} male; mean age 65.7 years). After 2 weeks, significantly more patients preferred Genuair than HandiHaler (79.1 vs 20.9{\%}; p < 0.0001). Overall satisfaction scores (4.6 vs 3.8; p < 0.0001) and willingness to continue use scores (84.0 vs 62.5; p < 0.0001) were significantly higher with Genuair versus HandiHaler. Significantly fewer patients made ≥ 1 critical error with Genuair only compared with HandiHaler only (2.9 vs 19.0{\%}; p < 0.0001). Conclusion: After 2 weeks' practice, patients preferred and were more willing to continue using Genuair than HandiHaler. Genuair was associated with higher patient satisfaction and fewer critical errors than HandiHaler Read More: http://informahealthcare.com/doi/abs/10.1517/17425247.2013.808186",
keywords = "IR-88746, METIS-301159",
author = "{van der Palen}, {Jacobus Adrianus Maria} and Thomas Ginko and Axel Kroker and {van der Valk}, Paul and Martijn Goosens and Laura Padulles and Beatriz Seoane and Ludmyla Rekeda and {Garcia Gil}, Esther",
year = "2013",
doi = "10.1517/17425247.2013.808186",
language = "English",
volume = "10",
pages = "1023--1031",
journal = "Expert opinion on drug delivery",
issn = "1742-5247",
publisher = "Taylor & Francis",
number = "8",

}

van der Palen, JAM, Ginko, T, Kroker, A, van der Valk, P, Goosens, M, Padulles, L, Seoane, B, Rekeda, L & Garcia Gil, E 2013, 'Preference, satisfaction and errors with two dry powder inhalers in patients with COPD' Expert opinion on drug delivery, vol. 10, no. 8, pp. 1023-1031. https://doi.org/10.1517/17425247.2013.808186

Preference, satisfaction and errors with two dry powder inhalers in patients with COPD. / van der Palen, Jacobus Adrianus Maria; Ginko, Thomas; Kroker, Axel; van der Valk, Paul; Goosens, Martijn; Padulles, Laura; Seoane, Beatriz; Rekeda, Ludmyla; Garcia Gil, Esther.

In: Expert opinion on drug delivery, Vol. 10, No. 8, 2013, p. 1023-1031.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Preference, satisfaction and errors with two dry powder inhalers in patients with COPD

AU - van der Palen, Jacobus Adrianus Maria

AU - Ginko, Thomas

AU - Kroker, Axel

AU - van der Valk, Paul

AU - Goosens, Martijn

AU - Padulles, Laura

AU - Seoane, Beatriz

AU - Rekeda, Ludmyla

AU - Garcia Gil, Esther

PY - 2013

Y1 - 2013

N2 - Objective: To assess preference, satisfaction and critical errors with a novel, breath-actuated, multi-dose dry powder inhaler (DPI; Genuair®/Pressair™), versus a widely used, single-dose DPI (HandiHaler®) in patients with moderate-to-severe chronic obstructive pulmonary disease. Methods: In this randomised, open-label, multicentre, cross-over study, patients (aged ≥ 40 years) inhaled placebo once daily through both inhalers for 2 weeks in addition to current medication. The primary end point was percentage of patients who preferred Genuair to HandiHaler. Overall patient satisfaction (5-point scale: 1 = very dissatisfied; 5 = very satisfied), critical errors and willingness to continue using each inhaler (0 = not willing; 100 = definitely willing) were assessed. Results: Of 130 patients randomised, 105 were included in the intent-to-treat population (71.4% male; mean age 65.7 years). After 2 weeks, significantly more patients preferred Genuair than HandiHaler (79.1 vs 20.9%; p < 0.0001). Overall satisfaction scores (4.6 vs 3.8; p < 0.0001) and willingness to continue use scores (84.0 vs 62.5; p < 0.0001) were significantly higher with Genuair versus HandiHaler. Significantly fewer patients made ≥ 1 critical error with Genuair only compared with HandiHaler only (2.9 vs 19.0%; p < 0.0001). Conclusion: After 2 weeks' practice, patients preferred and were more willing to continue using Genuair than HandiHaler. Genuair was associated with higher patient satisfaction and fewer critical errors than HandiHaler Read More: http://informahealthcare.com/doi/abs/10.1517/17425247.2013.808186

AB - Objective: To assess preference, satisfaction and critical errors with a novel, breath-actuated, multi-dose dry powder inhaler (DPI; Genuair®/Pressair™), versus a widely used, single-dose DPI (HandiHaler®) in patients with moderate-to-severe chronic obstructive pulmonary disease. Methods: In this randomised, open-label, multicentre, cross-over study, patients (aged ≥ 40 years) inhaled placebo once daily through both inhalers for 2 weeks in addition to current medication. The primary end point was percentage of patients who preferred Genuair to HandiHaler. Overall patient satisfaction (5-point scale: 1 = very dissatisfied; 5 = very satisfied), critical errors and willingness to continue using each inhaler (0 = not willing; 100 = definitely willing) were assessed. Results: Of 130 patients randomised, 105 were included in the intent-to-treat population (71.4% male; mean age 65.7 years). After 2 weeks, significantly more patients preferred Genuair than HandiHaler (79.1 vs 20.9%; p < 0.0001). Overall satisfaction scores (4.6 vs 3.8; p < 0.0001) and willingness to continue use scores (84.0 vs 62.5; p < 0.0001) were significantly higher with Genuair versus HandiHaler. Significantly fewer patients made ≥ 1 critical error with Genuair only compared with HandiHaler only (2.9 vs 19.0%; p < 0.0001). Conclusion: After 2 weeks' practice, patients preferred and were more willing to continue using Genuair than HandiHaler. Genuair was associated with higher patient satisfaction and fewer critical errors than HandiHaler Read More: http://informahealthcare.com/doi/abs/10.1517/17425247.2013.808186

KW - IR-88746

KW - METIS-301159

U2 - 10.1517/17425247.2013.808186

DO - 10.1517/17425247.2013.808186

M3 - Article

VL - 10

SP - 1023

EP - 1031

JO - Expert opinion on drug delivery

JF - Expert opinion on drug delivery

SN - 1742-5247

IS - 8

ER -