TY - JOUR
T1 - Preliminary results of a biohybrid lung assist concept
AU - Finocchiaro, N.
AU - Engwicht, S.
AU - Dittrich, B.
AU - Arens, J.
AU - Steinseifer, U.
AU - Wessling, M.
AU - Möller, M.
AU - Jockenhövel, S.
AU - Cornelissen, C.
PY - 2014/10/1
Y1 - 2014/10/1
N2 - Respiration of patients suffering from severe lung diseases e.g. cystic fibrosis or chronic obstructive pulmonary disease (COPD) can be supported by so-called "extracorporeal membrane oxygenation" (ECMO). Such an ECMO-system ensures CO2 elimination and O2 support by a membrane based on hollow fibers. Due to unspecific protein adsorption, resulting in a decrease of gas transfer and because of other side effects, the application is limited to short-term. However, as a bridge-to-decision or a bridge-to-transplant a system applicable for weeks to months is needed. The aim of the presented project is therefore the creation of a biocompatible device with a physiological gas-exchange surface made of an endothelialised flat membrane. The cell seeding requires an all new membrane and device concept. In order to develop a biohybrid lung assist device, clinicians, natural scientist, engineers, medical and material scientists work closely together. First cell seeding results on modified PMP membrane are presented.
AB - Respiration of patients suffering from severe lung diseases e.g. cystic fibrosis or chronic obstructive pulmonary disease (COPD) can be supported by so-called "extracorporeal membrane oxygenation" (ECMO). Such an ECMO-system ensures CO2 elimination and O2 support by a membrane based on hollow fibers. Due to unspecific protein adsorption, resulting in a decrease of gas transfer and because of other side effects, the application is limited to short-term. However, as a bridge-to-decision or a bridge-to-transplant a system applicable for weeks to months is needed. The aim of the presented project is therefore the creation of a biocompatible device with a physiological gas-exchange surface made of an endothelialised flat membrane. The cell seeding requires an all new membrane and device concept. In order to develop a biohybrid lung assist device, clinicians, natural scientist, engineers, medical and material scientists work closely together. First cell seeding results on modified PMP membrane are presented.
UR - http://www.scopus.com/inward/record.url?scp=84908202510&partnerID=8YFLogxK
U2 - 10.1515/bmt-2014-5003
DO - 10.1515/bmt-2014-5003
M3 - Article
AN - SCOPUS:84908202510
SN - 0013-5585
VL - 59
SP - S271-S273
JO - Biomedizinische Technik
JF - Biomedizinische Technik
ER -
