Preliminary results of a biohybrid lung assist concept

N. Finocchiaro*, S. Engwicht, B. Dittrich, J. Arens, U. Steinseifer, M. Wessling, M. Möller, S. Jockenhövel, C. Cornelissen

*Corresponding author for this work

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Abstract

Respiration of patients suffering from severe lung diseases e.g. cystic fibrosis or chronic obstructive pulmonary disease (COPD) can be supported by so-called "extracorporeal membrane oxygenation" (ECMO). Such an ECMO-system ensures CO2 elimination and O2 support by a membrane based on hollow fibers. Due to unspecific protein adsorption, resulting in a decrease of gas transfer and because of other side effects, the application is limited to short-term. However, as a bridge-to-decision or a bridge-to-transplant a system applicable for weeks to months is needed. The aim of the presented project is therefore the creation of a biocompatible device with a physiological gas-exchange surface made of an endothelialised flat membrane. The cell seeding requires an all new membrane and device concept. In order to develop a biohybrid lung assist device, clinicians, natural scientist, engineers, medical and material scientists work closely together. First cell seeding results on modified PMP membrane are presented.

Original languageEnglish
Pages (from-to)S271-S273
JournalBiomedizinische Technik
Volume59
DOIs
Publication statusPublished - 1 Oct 2014
Externally publishedYes

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    Finocchiaro, N., Engwicht, S., Dittrich, B., Arens, J., Steinseifer, U., Wessling, M., ... Cornelissen, C. (2014). Preliminary results of a biohybrid lung assist concept. Biomedizinische Technik, 59, S271-S273. https://doi.org/10.1515/bmt-2014-5003