Preparation of a Resorbable Osteoinductive Tricalcium Phosphate Ceramic

Huipin Yuan, K. de Groot, Clemens van Blitterswijk, Joost Dick de Bruijn

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Over the past decade we have demonstrated numerous times that calcium phosphates can be rendered with osteoinductive properties by introducing specific surface microstructures1. Since most of these calcium phosphates contained hydroxyapatite, they are either slowly or not resorbable2. Resorbability is an often sought after characteristic of calcium phosphates so that they can be gradually replaced by newly formed bone. The objective of this study was to prepare a resorbable surface microstructured tricalcium phosphate (TCP) ceramic and evaluate its osteoinductive property and resorption rate after intramuscular implantation in dogs. This material was then compared to the established and slowly resorbable osteoinductive biphasic calcium phosphate ceramic (BCP).
Original languageUndefined
Pages (from-to)14
JournalEuropean cells & materials
Issue numberSuppl. 2
Publication statusPublished - 2008


  • IR-80645

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