Preparation of designed poly(d,l-lactide)/nanosized hydroxyapatite composite structures by stereolithography

A. Ronca, L. Ambrosio, Dirk W. Grijpma

Research output: Contribution to journalArticleAcademicpeer-review

62 Citations (Scopus)

Abstract

The preparation of scaffolds to facilitate the replacement of damaged tissues and organs by means of tissue engineering has been much investigated. The key properties of the biomaterials used to prepare such scaffolds include biodegradability, biocompatibility and a well-defined three-dimensional 3-Dpore network structure. In this study a poly(d,l-lactide)/nanosized hydroxyapatite (PDLLA/nano-Hap) composite resin was prepared and used to fabricate composite films and computer designed porous scaffolds by micro-stereolithography, mixing varying quantities of nano-Hap powder and a liquid photoinitiator into a photo-crosslinkable PDLLA-diacrylate resin. The influence of nano-Hap on the rheological and photochemical properties of the resins was investigated, the materials being characterized with respect to their mechanical, thermal and morphological properties after post-preparation curing. In the cured composites stiffness was observed to increase with increasing concentration of nanoparticles. A computer designed construct with a pore network based on the Schwarz architecture was fabricated by stereolithography using PDLLA/nano-Hap composite resins.
Original languageEnglish
Pages (from-to)5989-5996
JournalActa biomaterialia
Volume9
Issue number4
DOIs
Publication statusPublished - 2013

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Stereolithography
Composite Resins
Durapatite
Composite structures
Hydroxyapatite
Scaffolds
Resins
Biodegradability
Biocompatible Materials
Composite films
Tissue Engineering
Scaffolds (biology)
Biocompatibility
Tissue engineering
Powders
Nanoparticles
Curing
Composite materials
Hot Temperature
Stiffness

Keywords

  • METIS-300419
  • IR-90084

Cite this

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title = "Preparation of designed poly(d,l-lactide)/nanosized hydroxyapatite composite structures by stereolithography",
abstract = "The preparation of scaffolds to facilitate the replacement of damaged tissues and organs by means of tissue engineering has been much investigated. The key properties of the biomaterials used to prepare such scaffolds include biodegradability, biocompatibility and a well-defined three-dimensional 3-Dpore network structure. In this study a poly(d,l-lactide)/nanosized hydroxyapatite (PDLLA/nano-Hap) composite resin was prepared and used to fabricate composite films and computer designed porous scaffolds by micro-stereolithography, mixing varying quantities of nano-Hap powder and a liquid photoinitiator into a photo-crosslinkable PDLLA-diacrylate resin. The influence of nano-Hap on the rheological and photochemical properties of the resins was investigated, the materials being characterized with respect to their mechanical, thermal and morphological properties after post-preparation curing. In the cured composites stiffness was observed to increase with increasing concentration of nanoparticles. A computer designed construct with a pore network based on the Schwarz architecture was fabricated by stereolithography using PDLLA/nano-Hap composite resins.",
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Preparation of designed poly(d,l-lactide)/nanosized hydroxyapatite composite structures by stereolithography. / Ronca, A.; Ambrosio, L.; Grijpma, Dirk W.

In: Acta biomaterialia, Vol. 9, No. 4, 2013, p. 5989-5996.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Preparation of designed poly(d,l-lactide)/nanosized hydroxyapatite composite structures by stereolithography

AU - Ronca, A.

AU - Ambrosio, L.

AU - Grijpma, Dirk W.

PY - 2013

Y1 - 2013

N2 - The preparation of scaffolds to facilitate the replacement of damaged tissues and organs by means of tissue engineering has been much investigated. The key properties of the biomaterials used to prepare such scaffolds include biodegradability, biocompatibility and a well-defined three-dimensional 3-Dpore network structure. In this study a poly(d,l-lactide)/nanosized hydroxyapatite (PDLLA/nano-Hap) composite resin was prepared and used to fabricate composite films and computer designed porous scaffolds by micro-stereolithography, mixing varying quantities of nano-Hap powder and a liquid photoinitiator into a photo-crosslinkable PDLLA-diacrylate resin. The influence of nano-Hap on the rheological and photochemical properties of the resins was investigated, the materials being characterized with respect to their mechanical, thermal and morphological properties after post-preparation curing. In the cured composites stiffness was observed to increase with increasing concentration of nanoparticles. A computer designed construct with a pore network based on the Schwarz architecture was fabricated by stereolithography using PDLLA/nano-Hap composite resins.

AB - The preparation of scaffolds to facilitate the replacement of damaged tissues and organs by means of tissue engineering has been much investigated. The key properties of the biomaterials used to prepare such scaffolds include biodegradability, biocompatibility and a well-defined three-dimensional 3-Dpore network structure. In this study a poly(d,l-lactide)/nanosized hydroxyapatite (PDLLA/nano-Hap) composite resin was prepared and used to fabricate composite films and computer designed porous scaffolds by micro-stereolithography, mixing varying quantities of nano-Hap powder and a liquid photoinitiator into a photo-crosslinkable PDLLA-diacrylate resin. The influence of nano-Hap on the rheological and photochemical properties of the resins was investigated, the materials being characterized with respect to their mechanical, thermal and morphological properties after post-preparation curing. In the cured composites stiffness was observed to increase with increasing concentration of nanoparticles. A computer designed construct with a pore network based on the Schwarz architecture was fabricated by stereolithography using PDLLA/nano-Hap composite resins.

KW - METIS-300419

KW - IR-90084

U2 - 10.1016/j.actbio.2012.12.004

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M3 - Article

VL - 9

SP - 5989

EP - 5996

JO - Acta biomaterialia

JF - Acta biomaterialia

SN - 1742-7061

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ER -