Preparation of poly(ε-caprolactone)-based tissue engineering scaffolds by stereolithography

Laura Elomaa, Sandra Da Silva Teixeira, Risto Hakala, Harri Korhonen, Dirk W. Grijpma, Jukka V. Seppala

Research output: Contribution to journalArticleAcademicpeer-review

171 Citations (Scopus)

Abstract

A photocrosslinkable poly(ε-caprolactone) (PCL)-based resin was developed and applied using stereolithography. No additional solvents were required during the structure preparation process. Three-armed PCL oligomers of varying molecular weights were synthesized, functionalized with methacrylic anhydride, and photocrosslinked, resulting in high gel content networks. Stereolithography was used to build designed porous scaffolds using the resin containing PCL macromer, Irgacure 369 photoinitiator, inhibitor and dye. A suitable resin viscosity was obtained by heating the resin during the curing process. The scaffolds precisely matched the computer-aided designs, with no observable material shrinkage. The average porosity was 70.5 ± 0.8%, and the average pore size was 465 μm. The pore network was highly interconnected. The photocrosslinkable, biodegradable PCL resin is well suited for the solvent-free fabrication of tissue engineering scaffolds by stereolithography.
Original languageEnglish
Pages (from-to)3850-3856
JournalActa biomaterialia
Volume7
Issue number11
DOIs
Publication statusPublished - 2011

Keywords

  • IR-104495
  • METIS-282989

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