Preparation of porous poly(trimethylene carbonate structures for controlled release applications using high pressure CO2

S.P. Nalawade; W.E. Hennink; D. Westerman; J. Feijen; A.P. Sam; G. Leeke; R.C.D. Santos; Dirk W. Grijpma; Jan Feijen

doi:10.1016/j.jconrel.2008.09.067

Preparation of porous poly(trimethylene carbonate structures for controlled release applications using high pressure CO2

S.P. Nalawade, W.E. Hennink (Editor), D. Westerman, J. Feijen (Editor), A.P. Sam (Editor), G. Leeke, R.C.D. Santos, Dirk W. Grijpma, Jan Feijen

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Abstract

Porous poly(trimethylene carbonate) structures can readily be prepared using high pressure CO2. Differences in CO2 solubility in the polymer matrix at the different processing temperatures and pressures lead to different pore morphologies upon depressurization. Furthermore, crystallization of the initially amorphous polymer leads to stable porous structures. This variation in pore structure can be used to tailor polymer matrix degradation rates and drug release profiles

Original language	Undefined
Pages	e73-e75
DOIs	https://doi.org/10.1016/j.jconrel.2008.09.067
Publication status	Published - 2 Apr 2008
Event	10th European Symposium on Controlled Drug Delivery, ESCDD 2008 - Noordwijk aan Zee, Netherlands Duration: 2 Apr 2008 → 4 Apr 2008 Conference number: 10

Conference

Conference	10th European Symposium on Controlled Drug Delivery, ESCDD 2008
Abbreviated title	ESCDD
Country/Territory	Netherlands
City	Noordwijk aan Zee
Period	2/04/08 → 4/04/08

Keywords

EC Grant Agreement nr.: FP6/500465
IR-69318
METIS-254003

Access to Document

10.1016/j.jconrel.2008.09.067

Cite this

Nalawade, S. P., Hennink, W. E. (Ed.), Westerman, D., Feijen, J. (Ed.), Sam, A. P. (Ed.), Leeke, G., Santos, R. C. D., Grijpma, D. W., & Feijen, J. (2008). Preparation of porous poly(trimethylene carbonate structures for controlled release applications using high pressure CO2. e73-e75. Paper presented at 10th European Symposium on Controlled Drug Delivery, ESCDD 2008, Noordwijk aan Zee, Netherlands. https://doi.org/10.1016/j.jconrel.2008.09.067

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title = "Preparation of porous poly(trimethylene carbonate structures for controlled release applications using high pressure CO2",

abstract = "Porous poly(trimethylene carbonate) structures can readily be prepared using high pressure CO2. Differences in CO2 solubility in the polymer matrix at the different processing temperatures and pressures lead to different pore morphologies upon depressurization. Furthermore, crystallization of the initially amorphous polymer leads to stable porous structures. This variation in pore structure can be used to tailor polymer matrix degradation rates and drug release profiles",

keywords = "EC Grant Agreement nr.: FP6/500465, IR-69318, METIS-254003",

author = "S.P. Nalawade and W.E. Hennink and D. Westerman and J. Feijen and A.P. Sam and G. Leeke and R.C.D. Santos and Grijpma, {Dirk W.} and Jan Feijen",

note = "Proceedings of the Tenth European Symposium on Controlled Drug Delivery ; 10th European Symposium on Controlled Drug Delivery, ESCDD 2008 ; Conference date: 02-04-2008 Through 04-04-2008",

year = "2008",

month = apr,

day = "2",

doi = "10.1016/j.jconrel.2008.09.067",

language = "Undefined",

pages = "e73--e75",

}

Nalawade, SP, Hennink, WE (ed.), Westerman, D, Feijen, J (ed.), Sam, AP (ed.), Leeke, G, Santos, RCD, Grijpma, DW & Feijen, J 2008, 'Preparation of porous poly(trimethylene carbonate structures for controlled release applications using high pressure CO2', Paper presented at 10th European Symposium on Controlled Drug Delivery, ESCDD 2008, Noordwijk aan Zee, Netherlands, 2/04/08 - 4/04/08 pp. e73-e75. https://doi.org/10.1016/j.jconrel.2008.09.067

TY - CONF

T1 - Preparation of porous poly(trimethylene carbonate structures for controlled release applications using high pressure CO2

AU - Nalawade, S.P.

AU - Westerman, D.

AU - Leeke, G.

AU - Santos, R.C.D.

AU - Grijpma, Dirk W.

AU - Feijen, Jan

A2 - Hennink, W.E.

A2 - Feijen, J.

A2 - Sam, A.P.

N1 - Conference code: 10

PY - 2008/4/2

Y1 - 2008/4/2

N2 - Porous poly(trimethylene carbonate) structures can readily be prepared using high pressure CO2. Differences in CO2 solubility in the polymer matrix at the different processing temperatures and pressures lead to different pore morphologies upon depressurization. Furthermore, crystallization of the initially amorphous polymer leads to stable porous structures. This variation in pore structure can be used to tailor polymer matrix degradation rates and drug release profiles

AB - Porous poly(trimethylene carbonate) structures can readily be prepared using high pressure CO2. Differences in CO2 solubility in the polymer matrix at the different processing temperatures and pressures lead to different pore morphologies upon depressurization. Furthermore, crystallization of the initially amorphous polymer leads to stable porous structures. This variation in pore structure can be used to tailor polymer matrix degradation rates and drug release profiles

KW - EC Grant Agreement nr.: FP6/500465

KW - IR-69318

KW - METIS-254003

U2 - 10.1016/j.jconrel.2008.09.067

DO - 10.1016/j.jconrel.2008.09.067

M3 - Paper

SP - e73-e75

T2 - 10th European Symposium on Controlled Drug Delivery, ESCDD 2008

Y2 - 2 April 2008 through 4 April 2008

ER -

Nalawade SP, Hennink WE, (ed.), Westerman D, Feijen J, (ed.), Sam AP, (ed.), Leeke G et al.. Preparation of porous poly(trimethylene carbonate structures for controlled release applications using high pressure CO2. 2008. Paper presented at 10th European Symposium on Controlled Drug Delivery, ESCDD 2008, Noordwijk aan Zee, Netherlands. doi: 10.1016/j.jconrel.2008.09.067