TY - JOUR
T1 - Printing "smart" Inks of Redox-Responsive Organometallic Polymers on Microelectrode Arrays for Molecular Sensing
AU - Cirelli, Marco
AU - Hao, Jinmeng
AU - Bor, Teunis C.
AU - Duvigneau, Joost
AU - Benson, Niels
AU - Akkerman, Remko
AU - Hempenius, Mark A.
AU - Vancso, G. Julius
N1 - ACS deal
PY - 2019/10/9
Y1 - 2019/10/9
N2 - Printing arrays of responsive spots for multiplexed sensing with electrochemical readout requires new molecules and precise, high-throughput deposition of active compounds on microelectrodes with spatial control. We have designed and developed new redox-responsive polymers, featuring a poly(ferrocenylsilane) (PFS) backbone and side groups with disulfide units, which allow an efficient and stable bonding to Au substrates, using sulfur-gold coupling chemistry in a "grafting-to" approach. The polymer molecules can be employed for area selective molecular sensing following their deposition by high-precision inkjet printing. The new PFS derivatives, which serve as "molecular inks", were characterized by 1H NMR, 13C NMR, and FTIR spectroscopies and by gel permeation chromatography. The viscosity and surface tension of the inks were assessed by rheology and pendant drop contact angle measurements, respectively. Commercial microelectrode arrays were modified with the new PFS ink by using inkjet printing in the "drop-on-demand" mode. FTIR spectroscopy, AFM, and EDX-SEM confirmed a successful, spatially localized PFS modification of the individual electrodes within the sensing cells of the microelectrode arrays. The potential application of these devices to act as an electrochemical sensor array was demonstrated with a model analyte, ascorbic acid, by using cyclic voltammetry and amperometric measurements.
AB - Printing arrays of responsive spots for multiplexed sensing with electrochemical readout requires new molecules and precise, high-throughput deposition of active compounds on microelectrodes with spatial control. We have designed and developed new redox-responsive polymers, featuring a poly(ferrocenylsilane) (PFS) backbone and side groups with disulfide units, which allow an efficient and stable bonding to Au substrates, using sulfur-gold coupling chemistry in a "grafting-to" approach. The polymer molecules can be employed for area selective molecular sensing following their deposition by high-precision inkjet printing. The new PFS derivatives, which serve as "molecular inks", were characterized by 1H NMR, 13C NMR, and FTIR spectroscopies and by gel permeation chromatography. The viscosity and surface tension of the inks were assessed by rheology and pendant drop contact angle measurements, respectively. Commercial microelectrode arrays were modified with the new PFS ink by using inkjet printing in the "drop-on-demand" mode. FTIR spectroscopy, AFM, and EDX-SEM confirmed a successful, spatially localized PFS modification of the individual electrodes within the sensing cells of the microelectrode arrays. The potential application of these devices to act as an electrochemical sensor array was demonstrated with a model analyte, ascorbic acid, by using cyclic voltammetry and amperometric measurements.
KW - Inkjet printing
KW - Electrochemical sensors
KW - Poly(ferrocenylsilane) (PFS)
KW - Microelectrode array (MEA) chip
KW - Drop-on-demand (DoD)
UR - http://www.scopus.com/inward/record.url?scp=85073031823&partnerID=8YFLogxK
U2 - 10.1021/acsami.9b11927
DO - 10.1021/acsami.9b11927
M3 - Article
C2 - 31525020
AN - SCOPUS:85073031823
SN - 1944-8244
VL - 11
SP - 37060
EP - 37068
JO - ACS applied materials & interfaces
JF - ACS applied materials & interfaces
IS - 40
ER -