Recent reports have appeared in the literature which deal with the synthesis and preliminary hydrolysis studies of controlled release formulations in which the bioactive agent is covalently bound to the sidechains of polymers via easily degradable bonds. Previous work in authors' laboratories has shown that synthetic poly- alpha -amino acids which are biodegradable can be developed and the rate of in vivo biodegradation can be controlled by varying the hydrophilicity of the sidechain groups. In the reported experiments, they used homopolymers of glutamic acid (PGS) as the polymeric backbone for the controlled release pro-drug sustem with the sidechain carboxyl groups of the glutamate moiety providing the hydrophilicity required for biodegration as well as the point of attachment for the drug. The drug used was the contraceptive progestin, 17- alpha -ethynyl-19-nortestosterone (norethindrone), which is known to be an active progestational compound and exhibits antifertility activity in both animals and humans. Experimental data are presented and briefly discussed.
|Number of pages||4|
|Journal||American Chemical Society, Polymer Preprints, Division of Polymer Chemistry|
|Publication status||Published - 1 Sep 1979|
|Event||Symposium on Polypeptides and Proteins 1979 - Washington, United States|
Duration: 10 Sep 1979 → 14 Sep 1979