PRO-DRUG CONTROLLED RELEASE FROM POLYGLUTAMIC ACID.

S. Mitra*, M. Van Dress, J. M. Anderson, R. V. Petersen, D. Gregonis, J. Feijen

*Corresponding author for this work

    Research output: Contribution to journalConference articleAcademicpeer-review

    10 Citations (Scopus)

    Abstract

    Recent reports have appeared in the literature which deal with the synthesis and preliminary hydrolysis studies of controlled release formulations in which the bioactive agent is covalently bound to the sidechains of polymers via easily degradable bonds. Previous work in authors' laboratories has shown that synthetic poly- alpha -amino acids which are biodegradable can be developed and the rate of in vivo biodegradation can be controlled by varying the hydrophilicity of the sidechain groups. In the reported experiments, they used homopolymers of glutamic acid (PGS) as the polymeric backbone for the controlled release pro-drug sustem with the sidechain carboxyl groups of the glutamate moiety providing the hydrophilicity required for biodegration as well as the point of attachment for the drug. The drug used was the contraceptive progestin, 17- alpha -ethynyl-19-nortestosterone (norethindrone), which is known to be an active progestational compound and exhibits antifertility activity in both animals and humans. Experimental data are presented and briefly discussed.

    Original languageEnglish
    Pages (from-to)32-35
    Number of pages4
    JournalAmerican Chemical Society, Polymer Preprints, Division of Polymer Chemistry
    Volume20
    Issue number2
    Publication statusPublished - 1 Sep 1979
    EventSymposium on Polypeptides and Proteins 1979 - Washington, United States
    Duration: 10 Sep 197914 Sep 1979

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