Probe-free semiconducting silicon nanowire platforms for biosensing

Arpita De, S. Chen, Edwin Carlen

    Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

    1 Citation (Scopus)

    Abstract

    This chapter discusses implementation of silicon nanowires (SiNW) for probe-free biosensing and their integration with microfluidic chambers for small volume sample confinement and delivery to an automated biosensor platform. The SiNW biosensor platform consists of three key elements: SiNW sensors, the probe layer for specific binding to a particular target molecule and gate voltage generation, and controlled delivery of small sample volumes that enables quantitative hybridization kinetics assessment directly from the real-time measurements. Advantages and disadvantages of using the nanoscale SiNW biosensors, and approaches to reduce the limitations are discussed. The chapter concludes with future trends and overall outlook
    Original languageEnglish
    Title of host publicationSemiconducting Silicon Nanowires for Biomedical Applications
    EditorsJ.L. Coffer
    PublisherWoodhead Publishing
    Pages229-265
    ISBN (Print)978-0-85709-766-8
    DOIs
    Publication statusPublished - 2014

    Keywords

    • METIS-310841

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