Processing methods for photoacoustic Doppler flowmetry with a clinical ultrasound scanner

Thore M. Bücking, Pim J. Van Den Berg, Stavroula Balabani, Wiendelt Steenbergen, Paul C. Beard, Joanna Brunker (Corresponding Author)

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Photoacoustic flowmetry (PAF) based on time-domain cross correlation of photoacoustic signals is a promising technique for deep tissue measurement of blood flow velocity. Signal processing has previously been developed for single element transducers. Here, the processing methods for acoustic resolution PAF using a clinical ultrasound transducer array are developed and validated using a 64-element transducer array with a -6 dB detection band of 11 to 17 MHz. Measurements were performed on a flow phantom consisting of a tube (580 μm inner diameter) perfused with human blood flowing at physiological speeds ranging from 3 to 25 mm / s. The processing pipeline comprised: image reconstruction, filtering, displacement detection, and masking. High-pass filtering and background subtraction were found to be key preprocessing steps to enable accurate flow velocity estimates, which were calculated using a cross-correlation based method. In addition, the regions of interest in the calculated velocity maps were defined using a masking approach based on the amplitude of the cross-correlation functions. These developments enabled blood flow measurements using a transducer array, bringing PAF one step closer to clinical applicability.

Original languageEnglish
Article number026009
JournalJournal of biomedical optics
Volume23
Issue number2
DOIs
Publication statusPublished - 1 Feb 2018

Fingerprint

Photoacoustic effect
scanners
Transducers
transducers
Ultrasonics
cross correlation
Blood
blood flow
masking
Processing
Flow velocity
flow velocity
flow measurement
Flow measurement
preprocessing
image reconstruction
Image reconstruction
subtraction
blood
signal processing

Keywords

  • Cross correlation
  • Flowmetry
  • Image processing
  • Masking
  • Photoacoustic Doppler effect
  • Transducer array
  • Blood flow

Cite this

Bücking, Thore M. ; Van Den Berg, Pim J. ; Balabani, Stavroula ; Steenbergen, Wiendelt ; Beard, Paul C. ; Brunker, Joanna. / Processing methods for photoacoustic Doppler flowmetry with a clinical ultrasound scanner. In: Journal of biomedical optics. 2018 ; Vol. 23, No. 2.
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Processing methods for photoacoustic Doppler flowmetry with a clinical ultrasound scanner. / Bücking, Thore M.; Van Den Berg, Pim J.; Balabani, Stavroula; Steenbergen, Wiendelt; Beard, Paul C.; Brunker, Joanna (Corresponding Author).

In: Journal of biomedical optics, Vol. 23, No. 2, 026009, 01.02.2018.

Research output: Contribution to journalArticleAcademicpeer-review

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