Production of Standardized Air Bubbles: Application to Embolism Studies

Peggy Palanchon, Jan Klein, N. de Jong

Research output: Contribution to journalArticleAcademicpeer-review

17 Citations (Scopus)
30 Downloads (Pure)

Abstract

Gaseous emboli may arise and enter into the circulation system during various clinical procedures. In order to better understand their immediate and long-term consequences, clinical investigations following the insertion of air bubbles into the body as well as new detection techniques need to be carried on. To this end, a device has been developed to generate a uniform stream of microbubbles with diameters ranging between 20 and 300 μm. This device comprises a glass micropipette connected to an air pressure source. The micropipette tip crosses a variable liquid flow and the bubbles produced are carried away by the flow. These bubbles have a very narrow size and density distribution: 90% of the bubbles lie within ±6% of the mean radius and the number of bubbles does not vary more than 10%. The size and density of the produced bubbles can be controlled by adjusting three independent parameters: the liquid flow, the gas pressure level, and the micropipette shape. For a given micropipette, increasing the liquid flow or decreasing the gas pressure level leads to a reduction of bubble size while the number of bubbles produced increases. As an example, doubling of the liquid flow results in a variation in bubble size up to 40%. This technique offers the advantage of generating uniform bubbles of known size and number depending on the settings selected. It appears to be a valuable tool for embolism studies such as the development of ultrasonic methods for detection of gaseous emboli.
Original languageEnglish
Pages (from-to)2558-2564
Number of pages7
JournalReview of scientific instruments
Volume74
DOIs
Publication statusPublished - 2003
Externally publishedYes

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