Production of Standardized Air Bubbles: Application to Embolism Studies

Peggy Palanchon, Jan Klein, N. de Jong

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)
2 Downloads (Pure)

Abstract

Gaseous emboli may arise and enter into the circulation system during various clinical procedures. In order to better understand their immediate and long-term consequences, clinical investigations following the insertion of air bubbles into the body as well as new detection techniques need to be carried on. To this end, a device has been developed to generate a uniform stream of microbubbles with diameters ranging between 20 and 300 μm. This device comprises a glass micropipette connected to an air pressure source. The micropipette tip crosses a variable liquid flow and the bubbles produced are carried away by the flow. These bubbles have a very narrow size and density distribution: 90% of the bubbles lie within ±6% of the mean radius and the number of bubbles does not vary more than 10%. The size and density of the produced bubbles can be controlled by adjusting three independent parameters: the liquid flow, the gas pressure level, and the micropipette shape. For a given micropipette, increasing the liquid flow or decreasing the gas pressure level leads to a reduction of bubble size while the number of bubbles produced increases. As an example, doubling of the liquid flow results in a variation in bubble size up to 40%. This technique offers the advantage of generating uniform bubbles of known size and number depending on the settings selected. It appears to be a valuable tool for embolism studies such as the development of ultrasonic methods for detection of gaseous emboli.
Original languageEnglish
Pages (from-to)2558-2564
Number of pages7
JournalReview of scientific instruments
Volume74
DOIs
Publication statusPublished - 2003
Externally publishedYes

Fingerprint

embolisms
bubbles
air
Liquids
Air
Bubbles (in fluids)
liquid flow
Gases
Ultrasonics
gas pressure
Glass
density distribution
insertion

Cite this

Palanchon, Peggy ; Klein, Jan ; de Jong, N. / Production of Standardized Air Bubbles: Application to Embolism Studies. In: Review of scientific instruments. 2003 ; Vol. 74. pp. 2558-2564.
@article{d57451f1f3b44e188bf65286ebf27fac,
title = "Production of Standardized Air Bubbles: Application to Embolism Studies",
abstract = "Gaseous emboli may arise and enter into the circulation system during various clinical procedures. In order to better understand their immediate and long-term consequences, clinical investigations following the insertion of air bubbles into the body as well as new detection techniques need to be carried on. To this end, a device has been developed to generate a uniform stream of microbubbles with diameters ranging between 20 and 300 μm. This device comprises a glass micropipette connected to an air pressure source. The micropipette tip crosses a variable liquid flow and the bubbles produced are carried away by the flow. These bubbles have a very narrow size and density distribution: 90{\%} of the bubbles lie within ±6{\%} of the mean radius and the number of bubbles does not vary more than 10{\%}. The size and density of the produced bubbles can be controlled by adjusting three independent parameters: the liquid flow, the gas pressure level, and the micropipette shape. For a given micropipette, increasing the liquid flow or decreasing the gas pressure level leads to a reduction of bubble size while the number of bubbles produced increases. As an example, doubling of the liquid flow results in a variation in bubble size up to 40{\%}. This technique offers the advantage of generating uniform bubbles of known size and number depending on the settings selected. It appears to be a valuable tool for embolism studies such as the development of ultrasonic methods for detection of gaseous emboli.",
author = "Peggy Palanchon and Jan Klein and {de Jong}, N.",
year = "2003",
doi = "10.1063/1.1561596",
language = "English",
volume = "74",
pages = "2558--2564",
journal = "Review of scientific instruments",
issn = "0034-6748",
publisher = "American Institute of Physics",

}

Production of Standardized Air Bubbles: Application to Embolism Studies. / Palanchon, Peggy; Klein, Jan; de Jong, N.

In: Review of scientific instruments, Vol. 74, 2003, p. 2558-2564.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Production of Standardized Air Bubbles: Application to Embolism Studies

AU - Palanchon, Peggy

AU - Klein, Jan

AU - de Jong, N.

PY - 2003

Y1 - 2003

N2 - Gaseous emboli may arise and enter into the circulation system during various clinical procedures. In order to better understand their immediate and long-term consequences, clinical investigations following the insertion of air bubbles into the body as well as new detection techniques need to be carried on. To this end, a device has been developed to generate a uniform stream of microbubbles with diameters ranging between 20 and 300 μm. This device comprises a glass micropipette connected to an air pressure source. The micropipette tip crosses a variable liquid flow and the bubbles produced are carried away by the flow. These bubbles have a very narrow size and density distribution: 90% of the bubbles lie within ±6% of the mean radius and the number of bubbles does not vary more than 10%. The size and density of the produced bubbles can be controlled by adjusting three independent parameters: the liquid flow, the gas pressure level, and the micropipette shape. For a given micropipette, increasing the liquid flow or decreasing the gas pressure level leads to a reduction of bubble size while the number of bubbles produced increases. As an example, doubling of the liquid flow results in a variation in bubble size up to 40%. This technique offers the advantage of generating uniform bubbles of known size and number depending on the settings selected. It appears to be a valuable tool for embolism studies such as the development of ultrasonic methods for detection of gaseous emboli.

AB - Gaseous emboli may arise and enter into the circulation system during various clinical procedures. In order to better understand their immediate and long-term consequences, clinical investigations following the insertion of air bubbles into the body as well as new detection techniques need to be carried on. To this end, a device has been developed to generate a uniform stream of microbubbles with diameters ranging between 20 and 300 μm. This device comprises a glass micropipette connected to an air pressure source. The micropipette tip crosses a variable liquid flow and the bubbles produced are carried away by the flow. These bubbles have a very narrow size and density distribution: 90% of the bubbles lie within ±6% of the mean radius and the number of bubbles does not vary more than 10%. The size and density of the produced bubbles can be controlled by adjusting three independent parameters: the liquid flow, the gas pressure level, and the micropipette shape. For a given micropipette, increasing the liquid flow or decreasing the gas pressure level leads to a reduction of bubble size while the number of bubbles produced increases. As an example, doubling of the liquid flow results in a variation in bubble size up to 40%. This technique offers the advantage of generating uniform bubbles of known size and number depending on the settings selected. It appears to be a valuable tool for embolism studies such as the development of ultrasonic methods for detection of gaseous emboli.

U2 - 10.1063/1.1561596

DO - 10.1063/1.1561596

M3 - Article

VL - 74

SP - 2558

EP - 2564

JO - Review of scientific instruments

JF - Review of scientific instruments

SN - 0034-6748

ER -