Prognosis and prognostic factors of patients with mesothelioma: A population-based study

Sjoukje van der Bij*, H. Koffijberg, J.A. Burgers, P. Baas, M.J. van de Vijver, B.A.J.M. de Mol, K.G.M. Moons

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

28 Citations (Scopus)

Abstract

Background: It is important to regularly update survival estimates of patients with malignant mesothelioma as prognosis may vary according to epidemiologic factors and diagnostic and therapeutic management. Methods: We assessed overall (baseline) survival as well as related prognostic variables in a large cohort of 1353 patients with a confirmed diagnosis of malignant mesothelioma between 2005 and 2008.

Results: About 50% of the patients were 70 years or older at diagnosis and the median latency time since start of asbestos exposure was 49 years. One year after diagnosis, 47% of the patients were alive, 20% after 2 years and 15% after 3 years. Prognostic variables independently associated with worse survival were: older age (HR=1.04 per year 95% CI (1.03-1.06)), sarcomatoid subtype (HR=2.45 95% CI (2.06-2.90)) and non-pleural localisation (HR=1.67 95% CI (1.26-2.22)).

Conclusion: Survival of patients with malignant mesothelioma is still limited and depends highly on patient age, mesothelioma subtype and localisation. In addition, a substantial part of the patients had a long latency time between asbestos exposure and diagnosis.

Original languageEnglish
Pages (from-to)161-164
Number of pages4
JournalBritish journal of cancer
Volume107
Issue number1
DOIs
Publication statusPublished - 26 Jun 2012

Keywords

  • Mesothelioma
  • population-based study
  • prognostic factors
  • survival

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    van der Bij, S., Koffijberg, H., Burgers, J. A., Baas, P., van de Vijver, M. J., de Mol, B. A. J. M., & Moons, K. G. M. (2012). Prognosis and prognostic factors of patients with mesothelioma: A population-based study. British journal of cancer, 107(1), 161-164. https://doi.org/10.1038/bjc.2012.245