Prognostic Factors for Locoregional Recurrences in Colon Cancer.

M.A.G. Elferink, O. Visser, T. Wiggers, R. Otter, R.A.E.M. Tollenaar, J.A. Langendijk, Sabine Siesling

    Research output: Contribution to journalArticleAcademicpeer-review

    19 Citations (Scopus)

    Abstract

    Background. There is increased interest in locoregional recurrences of rectal cancer. Despite comparable locoregional recurrence rates in colon cancer, only a few studies on locoregional recurrences among colon cancer patients have been published. This study was designed to identify prognostic factors for locoregional recurrences among patients with colon cancer in the Netherlands. Methods. The study population was composed of patients who underwent radical surgical resections for invasive colon carcinoma, diagnosed in three regions of the Netherlands from 2000 to 2003. The Kaplan-Meier method was used to calculate 5-year locoregional recurrence rates (LRR). Conditional hazard rates were estimated by the lifetable method. Multivariate Cox regression analyses were performed to identify prognostic factors and to calculate a Locoregional Recurrence Risk Score (LRRS). Results. In total 127 of 2,282 patients developed locoregional recurrences within 5 years (LRR 6.4%). The risk of developing a locoregional recurrence was highest at 0.5–1 year after surgery. Patients with left-sided tumors, T3-T4 tumors, and positive lymph nodes and those who did not receive adjuvant chemotherapy were more likely to develop locoregional recurrences. Four risk groups based on the LRRS were defined. Five-year LRR was 2.5% for the very low-risk group and 25.1% for the high-risk group. Conclusions. Although the locoregional recurrence rate in this study was relatively low, it remains a considerable problem. Identifying individual patients who might benefit from adjuvant chemotherapy may reduce the locoregional recurrence rate
    Original languageEnglish
    Pages (from-to)2203-2211
    JournalAnnals of surgical oncology
    Volume19
    Issue number7
    DOIs
    Publication statusPublished - 2012

    Fingerprint

    Colonic Neoplasms
    Recurrence
    Adjuvant Chemotherapy
    Rectal Neoplasms
    Netherlands
    Neoplasms
    Lymph Nodes
    Regression Analysis
    Carcinoma
    Population

    Keywords

    • IR-81258
    • METIS-287751

    Cite this

    Elferink, M. A. G., Visser, O., Wiggers, T., Otter, R., Tollenaar, R. A. E. M., Langendijk, J. A., & Siesling, S. (2012). Prognostic Factors for Locoregional Recurrences in Colon Cancer. Annals of surgical oncology, 19(7), 2203-2211. https://doi.org/10.1245/s10434-011-2183-4
    Elferink, M.A.G. ; Visser, O. ; Wiggers, T. ; Otter, R. ; Tollenaar, R.A.E.M. ; Langendijk, J.A. ; Siesling, Sabine. / Prognostic Factors for Locoregional Recurrences in Colon Cancer. In: Annals of surgical oncology. 2012 ; Vol. 19, No. 7. pp. 2203-2211.
    @article{bc14afe021734d999bb1cb2bae6de078,
    title = "Prognostic Factors for Locoregional Recurrences in Colon Cancer.",
    abstract = "Background. There is increased interest in locoregional recurrences of rectal cancer. Despite comparable locoregional recurrence rates in colon cancer, only a few studies on locoregional recurrences among colon cancer patients have been published. This study was designed to identify prognostic factors for locoregional recurrences among patients with colon cancer in the Netherlands. Methods. The study population was composed of patients who underwent radical surgical resections for invasive colon carcinoma, diagnosed in three regions of the Netherlands from 2000 to 2003. The Kaplan-Meier method was used to calculate 5-year locoregional recurrence rates (LRR). Conditional hazard rates were estimated by the lifetable method. Multivariate Cox regression analyses were performed to identify prognostic factors and to calculate a Locoregional Recurrence Risk Score (LRRS). Results. In total 127 of 2,282 patients developed locoregional recurrences within 5 years (LRR 6.4{\%}). The risk of developing a locoregional recurrence was highest at 0.5–1 year after surgery. Patients with left-sided tumors, T3-T4 tumors, and positive lymph nodes and those who did not receive adjuvant chemotherapy were more likely to develop locoregional recurrences. Four risk groups based on the LRRS were defined. Five-year LRR was 2.5{\%} for the very low-risk group and 25.1{\%} for the high-risk group. Conclusions. Although the locoregional recurrence rate in this study was relatively low, it remains a considerable problem. Identifying individual patients who might benefit from adjuvant chemotherapy may reduce the locoregional recurrence rate",
    keywords = "IR-81258, METIS-287751",
    author = "M.A.G. Elferink and O. Visser and T. Wiggers and R. Otter and R.A.E.M. Tollenaar and J.A. Langendijk and Sabine Siesling",
    year = "2012",
    doi = "10.1245/s10434-011-2183-4",
    language = "English",
    volume = "19",
    pages = "2203--2211",
    journal = "Annals of surgical oncology",
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    Elferink, MAG, Visser, O, Wiggers, T, Otter, R, Tollenaar, RAEM, Langendijk, JA & Siesling, S 2012, 'Prognostic Factors for Locoregional Recurrences in Colon Cancer.' Annals of surgical oncology, vol. 19, no. 7, pp. 2203-2211. https://doi.org/10.1245/s10434-011-2183-4

    Prognostic Factors for Locoregional Recurrences in Colon Cancer. / Elferink, M.A.G.; Visser, O.; Wiggers, T.; Otter, R.; Tollenaar, R.A.E.M.; Langendijk, J.A.; Siesling, Sabine.

    In: Annals of surgical oncology, Vol. 19, No. 7, 2012, p. 2203-2211.

    Research output: Contribution to journalArticleAcademicpeer-review

    TY - JOUR

    T1 - Prognostic Factors for Locoregional Recurrences in Colon Cancer.

    AU - Elferink, M.A.G.

    AU - Visser, O.

    AU - Wiggers, T.

    AU - Otter, R.

    AU - Tollenaar, R.A.E.M.

    AU - Langendijk, J.A.

    AU - Siesling, Sabine

    PY - 2012

    Y1 - 2012

    N2 - Background. There is increased interest in locoregional recurrences of rectal cancer. Despite comparable locoregional recurrence rates in colon cancer, only a few studies on locoregional recurrences among colon cancer patients have been published. This study was designed to identify prognostic factors for locoregional recurrences among patients with colon cancer in the Netherlands. Methods. The study population was composed of patients who underwent radical surgical resections for invasive colon carcinoma, diagnosed in three regions of the Netherlands from 2000 to 2003. The Kaplan-Meier method was used to calculate 5-year locoregional recurrence rates (LRR). Conditional hazard rates were estimated by the lifetable method. Multivariate Cox regression analyses were performed to identify prognostic factors and to calculate a Locoregional Recurrence Risk Score (LRRS). Results. In total 127 of 2,282 patients developed locoregional recurrences within 5 years (LRR 6.4%). The risk of developing a locoregional recurrence was highest at 0.5–1 year after surgery. Patients with left-sided tumors, T3-T4 tumors, and positive lymph nodes and those who did not receive adjuvant chemotherapy were more likely to develop locoregional recurrences. Four risk groups based on the LRRS were defined. Five-year LRR was 2.5% for the very low-risk group and 25.1% for the high-risk group. Conclusions. Although the locoregional recurrence rate in this study was relatively low, it remains a considerable problem. Identifying individual patients who might benefit from adjuvant chemotherapy may reduce the locoregional recurrence rate

    AB - Background. There is increased interest in locoregional recurrences of rectal cancer. Despite comparable locoregional recurrence rates in colon cancer, only a few studies on locoregional recurrences among colon cancer patients have been published. This study was designed to identify prognostic factors for locoregional recurrences among patients with colon cancer in the Netherlands. Methods. The study population was composed of patients who underwent radical surgical resections for invasive colon carcinoma, diagnosed in three regions of the Netherlands from 2000 to 2003. The Kaplan-Meier method was used to calculate 5-year locoregional recurrence rates (LRR). Conditional hazard rates were estimated by the lifetable method. Multivariate Cox regression analyses were performed to identify prognostic factors and to calculate a Locoregional Recurrence Risk Score (LRRS). Results. In total 127 of 2,282 patients developed locoregional recurrences within 5 years (LRR 6.4%). The risk of developing a locoregional recurrence was highest at 0.5–1 year after surgery. Patients with left-sided tumors, T3-T4 tumors, and positive lymph nodes and those who did not receive adjuvant chemotherapy were more likely to develop locoregional recurrences. Four risk groups based on the LRRS were defined. Five-year LRR was 2.5% for the very low-risk group and 25.1% for the high-risk group. Conclusions. Although the locoregional recurrence rate in this study was relatively low, it remains a considerable problem. Identifying individual patients who might benefit from adjuvant chemotherapy may reduce the locoregional recurrence rate

    KW - IR-81258

    KW - METIS-287751

    U2 - 10.1245/s10434-011-2183-4

    DO - 10.1245/s10434-011-2183-4

    M3 - Article

    VL - 19

    SP - 2203

    EP - 2211

    JO - Annals of surgical oncology

    JF - Annals of surgical oncology

    SN - 1068-9265

    IS - 7

    ER -

    Elferink MAG, Visser O, Wiggers T, Otter R, Tollenaar RAEM, Langendijk JA et al. Prognostic Factors for Locoregional Recurrences in Colon Cancer. Annals of surgical oncology. 2012;19(7):2203-2211. https://doi.org/10.1245/s10434-011-2183-4