TY - JOUR
T1 - Programmable bio-ionic liquid functionalized hydrogels for in situ 3D bioprinting of electronics at the tissue interface
AU - Krishnadoss, Vaishali
AU - Kanjilal, Baishali
AU - Masoumi, Arameh
AU - Banerjee, Aihik
AU - Dehzangi, Iman
AU - Pezhouman, Arash
AU - Ardehali, Reza
AU - Martins-Green, Manuela
AU - Leijten, Jeroen
AU - Noshadi, Iman
N1 - Funding Information:
The authors are grateful for financial support from the UC RiversideStartupFund and NSF 1919092 and 2136603 awards and CIRM-TRANSCEND (Award#:EDUC4-12752).
Funding Information:
The authors are grateful for financial support from the UC Riverside StartupFund and NSF 1919092 and 2136603 awards and CIRM-TRANSCEND (Award#: EDUC4-12752 ).
Publisher Copyright:
© 2023
PY - 2023/3
Y1 - 2023/3
N2 - The increased demand for personalized wearable and implantable medical devices has created the need for the generation of electronics that interface with living systems. Current bioelectronics has not fully resolved mismatches between biological systems and engineered circuits, resulting in tissue injury and pain. Thus, there is an unmet need to develop materials for the fabrication of wearable electronics that are biocompatible at the tissue interface. Here, we developed a tailorable gelatin-based bio-ink functionalized with a choline bio-ionic liquid (BIL) for in situ 3D bioprinting of bioelectronics at the tissue interface. The resultant photocrosslinked polymer is programmable, transparent, ion conductive, and flexible. BILs are stably conjugated with a gelatin methacryloyl (GelMA) hydrogel using photocrosslinking to make BioGel, which routes ionic current with high resolution and enables localized electrical stimulation delivery. Controllable crosslinking, achieved by varying reactants composition, allows the BioGel bio-ink platform for easy and rapid in-situ 3D bioprinting of complex designs directly on skin tissue. Bio-ionic modified polymers thus represent a versatile and wide-applicable bio-ink solution for personalized bioelectronics fabrication that minimizes tissue damage.
AB - The increased demand for personalized wearable and implantable medical devices has created the need for the generation of electronics that interface with living systems. Current bioelectronics has not fully resolved mismatches between biological systems and engineered circuits, resulting in tissue injury and pain. Thus, there is an unmet need to develop materials for the fabrication of wearable electronics that are biocompatible at the tissue interface. Here, we developed a tailorable gelatin-based bio-ink functionalized with a choline bio-ionic liquid (BIL) for in situ 3D bioprinting of bioelectronics at the tissue interface. The resultant photocrosslinked polymer is programmable, transparent, ion conductive, and flexible. BILs are stably conjugated with a gelatin methacryloyl (GelMA) hydrogel using photocrosslinking to make BioGel, which routes ionic current with high resolution and enables localized electrical stimulation delivery. Controllable crosslinking, achieved by varying reactants composition, allows the BioGel bio-ink platform for easy and rapid in-situ 3D bioprinting of complex designs directly on skin tissue. Bio-ionic modified polymers thus represent a versatile and wide-applicable bio-ink solution for personalized bioelectronics fabrication that minimizes tissue damage.
KW - Bio-ionic liquid functionalization
KW - Bioelectronics
KW - Biological tissue
KW - Biomaterials
KW - In-situ 3D bioprinting
UR - http://www.scopus.com/inward/record.url?scp=85148015319&partnerID=8YFLogxK
U2 - 10.1016/j.mtadv.2023.100352
DO - 10.1016/j.mtadv.2023.100352
M3 - Article
AN - SCOPUS:85148015319
SN - 2590-0498
VL - 17
JO - Materials Today Advances
JF - Materials Today Advances
M1 - 100352
ER -