Properties, extraction methods, and delivery systems for curcumin as a natural source of beneficial health effects

Aleksandra Zielińska; Henrique Alves; Vânia Marques; Alessandra Durazzo; Massimo Lucarini; Thais F. Alves; Margreet Morsink; Niels Willemen; Piotr Eder; Marco V. Chaud; Patricia Severino; Antonello Santini; Eliana B. Souto

doi:10.3390/medicina56070336

Properties, extraction methods, and delivery systems for curcumin as a natural source of beneficial health effects

Aleksandra Zielińska, Henrique Alves, Vânia Marques, Alessandra Durazzo, Massimo Lucarini, Thais F. Alves, Margreet Morsink, Niels Willemen, Piotr Eder, Marco V. Chaud, Patricia Severino, Antonello Santini^*, Eliana B. Souto

^*Corresponding author for this work

Developmental BioEngineering

Research output: Contribution to journal › Review article › Academic › peer-review

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Abstract

This review discusses the impact of curcumin—an aromatic phytoextract from the turmeric (Curcuma longa) rhizome—as an effective therapeutic agent. Despite all of the beneficial health properties ensured by curcumin application, its pharmacological efficacy is compromised in vivo due to poor aqueous solubility, high metabolism, and rapid excretion that may result in poor systemic bioavailability. To overcome these problems, novel nanosystems have been proposed to enhance its bioavailability and bioactivity by reducing the particle size, the modification of surfaces, and the encapsulation efficiency of curcumin with different nanocarriers. The solutions based on nanotechnology can improve the perspective for medical patients with serious illnesses. In this review, we discuss commonly used curcumin-loaded bio-based nanoparticles that should be implemented for overcoming the innate constraints of this natural ingredient. Furthermore, the associated challenges regarding the potential applications in combination therapies are discussed as well.

Original language	English
Article number	336
Pages (from-to)	1-19
Number of pages	19
Journal	Medicina (Lithuania)
Volume	56
Issue number	7
DOIs	https://doi.org/10.3390/medicina56070336
Publication status	Published - Jul 2020

Keywords

Cancer
Curcumin
Health properties
Nanoparticles
Nanopharmaceutics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/medicina56070336Licence: CC BY

medicina-56-00336Final published version, 1.27 MBLicence: CC BY

Cite this

Zielińska, A., Alves, H., Marques, V., Durazzo, A., Lucarini, M., Alves, T. F., Morsink, M., Willemen, N., Eder, P., Chaud, M. V., Severino, P., Santini, A., & Souto, E. B. (2020). Properties, extraction methods, and delivery systems for curcumin as a natural source of beneficial health effects. Medicina (Lithuania), 56(7), 1-19. Article 336. https://doi.org/10.3390/medicina56070336

@article{0b73a8c35cc649f6a6179fe632c88c6e,

title = "Properties, extraction methods, and delivery systems for curcumin as a natural source of beneficial health effects",

abstract = "This review discusses the impact of curcumin—an aromatic phytoextract from the turmeric (Curcuma longa) rhizome—as an effective therapeutic agent. Despite all of the beneficial health properties ensured by curcumin application, its pharmacological efficacy is compromised in vivo due to poor aqueous solubility, high metabolism, and rapid excretion that may result in poor systemic bioavailability. To overcome these problems, novel nanosystems have been proposed to enhance its bioavailability and bioactivity by reducing the particle size, the modification of surfaces, and the encapsulation efficiency of curcumin with different nanocarriers. The solutions based on nanotechnology can improve the perspective for medical patients with serious illnesses. In this review, we discuss commonly used curcumin-loaded bio-based nanoparticles that should be implemented for overcoming the innate constraints of this natural ingredient. Furthermore, the associated challenges regarding the potential applications in combination therapies are discussed as well.",

keywords = "Cancer, Curcumin, Health properties, Nanoparticles, Nanopharmaceutics",

author = "Aleksandra Zieli{\'n}ska and Henrique Alves and V{\^a}nia Marques and Alessandra Durazzo and Massimo Lucarini and Alves, {Thais F.} and Margreet Morsink and Niels Willemen and Piotr Eder and Chaud, {Marco V.} and Patricia Severino and Antonello Santini and Souto, {Eliana B.}",

note = "Funding Information: The authors acknowledge the sponsorship received from the Portuguese Science and Technology Foundation, Ministry of Science and Education (FCT/MEC) through national funds, co-financed by FEDER, under the Partnership Agreement PT2020 for the project UIDB/04469/2020 (strategic fund) granted to E.B.S., the National Council for Scientific and Technological Development (CNPq), Brazil, for the project 425271/2016-1 granted to M.V.C., and the Coordena??o Aperfei?oamento de Pessoal de Nivel Superior (CAPES) and Funda??o de ?mparo ? Pesquisa do Estado de Sergipe (FAPITEC) (88887.159533/2017-00), Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico (CNPq 301964/2019-0 Chamada 06/2019, and Chamada CNPq n? 01/2019), and Banco do Nordeste (FUNDECI 2017.0016) granted to P.S. The authors acknowledge the support of the research project: Nutraceutica come supporto nutrizionale nel paziente oncologico, CUP: B83D18000140007. Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2020",

month = jul,

doi = "10.3390/medicina56070336",

language = "English",

volume = "56",

pages = "1--19",

journal = "Medicina (Lithuania)",

issn = "1010-660X",

publisher = "MDPI",

number = "7",

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Zielińska, A, Alves, H, Marques, V, Durazzo, A, Lucarini, M, Alves, TF, Morsink, M, Willemen, N, Eder, P, Chaud, MV, Severino, P, Santini, A & Souto, EB 2020, 'Properties, extraction methods, and delivery systems for curcumin as a natural source of beneficial health effects', Medicina (Lithuania), vol. 56, no. 7, 336, pp. 1-19. https://doi.org/10.3390/medicina56070336

TY - JOUR

T1 - Properties, extraction methods, and delivery systems for curcumin as a natural source of beneficial health effects

AU - Zielińska, Aleksandra

AU - Alves, Henrique

AU - Marques, Vânia

AU - Durazzo, Alessandra

AU - Lucarini, Massimo

AU - Alves, Thais F.

AU - Morsink, Margreet

AU - Willemen, Niels

AU - Eder, Piotr

AU - Chaud, Marco V.

AU - Severino, Patricia

AU - Santini, Antonello

AU - Souto, Eliana B.

N1 - Funding Information: The authors acknowledge the sponsorship received from the Portuguese Science and Technology Foundation, Ministry of Science and Education (FCT/MEC) through national funds, co-financed by FEDER, under the Partnership Agreement PT2020 for the project UIDB/04469/2020 (strategic fund) granted to E.B.S., the National Council for Scientific and Technological Development (CNPq), Brazil, for the project 425271/2016-1 granted to M.V.C., and the Coordena??o Aperfei?oamento de Pessoal de Nivel Superior (CAPES) and Funda??o de ?mparo ? Pesquisa do Estado de Sergipe (FAPITEC) (88887.159533/2017-00), Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico (CNPq 301964/2019-0 Chamada 06/2019, and Chamada CNPq n? 01/2019), and Banco do Nordeste (FUNDECI 2017.0016) granted to P.S. The authors acknowledge the support of the research project: Nutraceutica come supporto nutrizionale nel paziente oncologico, CUP: B83D18000140007. Publisher Copyright: © 2020 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2020/7

Y1 - 2020/7

N2 - This review discusses the impact of curcumin—an aromatic phytoextract from the turmeric (Curcuma longa) rhizome—as an effective therapeutic agent. Despite all of the beneficial health properties ensured by curcumin application, its pharmacological efficacy is compromised in vivo due to poor aqueous solubility, high metabolism, and rapid excretion that may result in poor systemic bioavailability. To overcome these problems, novel nanosystems have been proposed to enhance its bioavailability and bioactivity by reducing the particle size, the modification of surfaces, and the encapsulation efficiency of curcumin with different nanocarriers. The solutions based on nanotechnology can improve the perspective for medical patients with serious illnesses. In this review, we discuss commonly used curcumin-loaded bio-based nanoparticles that should be implemented for overcoming the innate constraints of this natural ingredient. Furthermore, the associated challenges regarding the potential applications in combination therapies are discussed as well.

AB - This review discusses the impact of curcumin—an aromatic phytoextract from the turmeric (Curcuma longa) rhizome—as an effective therapeutic agent. Despite all of the beneficial health properties ensured by curcumin application, its pharmacological efficacy is compromised in vivo due to poor aqueous solubility, high metabolism, and rapid excretion that may result in poor systemic bioavailability. To overcome these problems, novel nanosystems have been proposed to enhance its bioavailability and bioactivity by reducing the particle size, the modification of surfaces, and the encapsulation efficiency of curcumin with different nanocarriers. The solutions based on nanotechnology can improve the perspective for medical patients with serious illnesses. In this review, we discuss commonly used curcumin-loaded bio-based nanoparticles that should be implemented for overcoming the innate constraints of this natural ingredient. Furthermore, the associated challenges regarding the potential applications in combination therapies are discussed as well.

KW - Cancer

KW - Curcumin

KW - Health properties

KW - Nanoparticles

KW - Nanopharmaceutics

UR - http://www.scopus.com/inward/record.url?scp=85087460616&partnerID=8YFLogxK

U2 - 10.3390/medicina56070336

DO - 10.3390/medicina56070336

M3 - Review article

C2 - 32635279

AN - SCOPUS:85087460616

SN - 1010-660X

VL - 56

SP - 1

EP - 19

JO - Medicina (Lithuania)

JF - Medicina (Lithuania)

IS - 7

M1 - 336

ER -

Properties, extraction methods, and delivery systems for curcumin as a natural source of beneficial health effects

Abstract

Keywords

UN SDGs

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