Abstract
Objective
Daily use of inhaled corticosteroids (ICS) reduces exercise induced bronchoconstriction (EIB) in asthmatic children. A high single dose of ICS also provided acute protection against EIB. Objective of this study is to investigate whether a low single dose of ICS offers protection against EIB in asthmatic children.
Methods
31 Mild asthmatic children not currently treated with inhaled corticosteroids, 5–16 years, with EIB (fall in FEV0.5/1 ≥ 13%) were included in a prospective intervention study. They performed two ECT's within 2 weeks. Four hours before the second test children inhaled 200 μg beclomethasone-dipropionate (BDP) with a breath-actuated inhaler (BAI).
Results
The median fall in FEV0.5/1 after 200 μg BDP was significantly reduced from 30.9% at baseline to 16.0% (P < 0.001). Twenty children (64.5%) showed a good response to 200 μg BDP (≥50% decrease in fall of FEV0.5/1), while 8 children showed a moderate response (25–50%), and three children showed no response at all (< 25%).
Conclusion
A low single dose ICS offers acute protection against EIB in the majority of asthmatic children not currently treated with inhaled corticosteroids
Original language | English |
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Pages (from-to) | 1178-1183 |
Journal | Pediatric pulmonology |
Volume | 50 |
Issue number | 12 |
DOIs | |
Publication status | Published - 21 Nov 2015 |
Keywords
- IR-97162
- METIS-311699