Protective effect of a low single dose inhaled steroid against exercise induced bronchoconstriction

R. Visser; M. Wind; B. de Graaf; Franciscus H.C. de Jongh; Jacobus Adrianus Maria van der Palen; B.J. Thio

doi:10.1002/ppul.23144

Protective effect of a low single dose inhaled steroid against exercise induced bronchoconstriction

R. Visser, M. Wind, B. de Graaf, Franciscus H.C. de Jongh, Jacobus Adrianus Maria van der Palen, B.J. Thio

Research output: Contribution to journal › Article › Academic › peer-review

4 Citations (Scopus)

Abstract

Objective Daily use of inhaled corticosteroids (ICS) reduces exercise induced bronchoconstriction (EIB) in asthmatic children. A high single dose of ICS also provided acute protection against EIB. Objective of this study is to investigate whether a low single dose of ICS offers protection against EIB in asthmatic children. Methods 31 Mild asthmatic children not currently treated with inhaled corticosteroids, 5–16 years, with EIB (fall in FEV0.5/1 ≥ 13%) were included in a prospective intervention study. They performed two ECT's within 2 weeks. Four hours before the second test children inhaled 200 μg beclomethasone-dipropionate (BDP) with a breath-actuated inhaler (BAI). Results The median fall in FEV0.5/1 after 200 μg BDP was significantly reduced from 30.9% at baseline to 16.0% (P < 0.001). Twenty children (64.5%) showed a good response to 200 μg BDP (≥50% decrease in fall of FEV0.5/1), while 8 children showed a moderate response (25–50%), and three children showed no response at all (< 25%). Conclusion A low single dose ICS offers acute protection against EIB in the majority of asthmatic children not currently treated with inhaled corticosteroids

Original language	English
Pages (from-to)	1178-1183
Journal	Pediatric pulmonology
Volume	50
Issue number	12
DOIs	https://doi.org/10.1002/ppul.23144
Publication status	Published - 21 Nov 2015

Keywords

IR-97162
METIS-311699

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10.1002/ppul.23144

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title = "Protective effect of a low single dose inhaled steroid against exercise induced bronchoconstriction",

abstract = "Objective Daily use of inhaled corticosteroids (ICS) reduces exercise induced bronchoconstriction (EIB) in asthmatic children. A high single dose of ICS also provided acute protection against EIB. Objective of this study is to investigate whether a low single dose of ICS offers protection against EIB in asthmatic children. Methods 31 Mild asthmatic children not currently treated with inhaled corticosteroids, 5–16 years, with EIB (fall in FEV0.5/1 ≥ 13%) were included in a prospective intervention study. They performed two ECT's within 2 weeks. Four hours before the second test children inhaled 200 μg beclomethasone-dipropionate (BDP) with a breath-actuated inhaler (BAI). Results The median fall in FEV0.5/1 after 200 μg BDP was significantly reduced from 30.9% at baseline to 16.0% (P < 0.001). Twenty children (64.5%) showed a good response to 200 μg BDP (≥50% decrease in fall of FEV0.5/1), while 8 children showed a moderate response (25–50%), and three children showed no response at all (< 25%). Conclusion A low single dose ICS offers acute protection against EIB in the majority of asthmatic children not currently treated with inhaled corticosteroids",

keywords = "IR-97162, METIS-311699",

author = "R. Visser and M. Wind and {de Graaf}, B. and {de Jongh}, {Franciscus H.C.} and {van der Palen}, {Jacobus Adrianus Maria} and B.J. Thio",

year = "2015",

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doi = "10.1002/ppul.23144",

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T1 - Protective effect of a low single dose inhaled steroid against exercise induced bronchoconstriction

AU - Visser, R.

AU - Wind, M.

AU - de Graaf, B.

AU - de Jongh, Franciscus H.C.

AU - van der Palen, Jacobus Adrianus Maria

AU - Thio, B.J.

PY - 2015/11/21

Y1 - 2015/11/21

N2 - Objective Daily use of inhaled corticosteroids (ICS) reduces exercise induced bronchoconstriction (EIB) in asthmatic children. A high single dose of ICS also provided acute protection against EIB. Objective of this study is to investigate whether a low single dose of ICS offers protection against EIB in asthmatic children. Methods 31 Mild asthmatic children not currently treated with inhaled corticosteroids, 5–16 years, with EIB (fall in FEV0.5/1 ≥ 13%) were included in a prospective intervention study. They performed two ECT's within 2 weeks. Four hours before the second test children inhaled 200 μg beclomethasone-dipropionate (BDP) with a breath-actuated inhaler (BAI). Results The median fall in FEV0.5/1 after 200 μg BDP was significantly reduced from 30.9% at baseline to 16.0% (P < 0.001). Twenty children (64.5%) showed a good response to 200 μg BDP (≥50% decrease in fall of FEV0.5/1), while 8 children showed a moderate response (25–50%), and three children showed no response at all (< 25%). Conclusion A low single dose ICS offers acute protection against EIB in the majority of asthmatic children not currently treated with inhaled corticosteroids

AB - Objective Daily use of inhaled corticosteroids (ICS) reduces exercise induced bronchoconstriction (EIB) in asthmatic children. A high single dose of ICS also provided acute protection against EIB. Objective of this study is to investigate whether a low single dose of ICS offers protection against EIB in asthmatic children. Methods 31 Mild asthmatic children not currently treated with inhaled corticosteroids, 5–16 years, with EIB (fall in FEV0.5/1 ≥ 13%) were included in a prospective intervention study. They performed two ECT's within 2 weeks. Four hours before the second test children inhaled 200 μg beclomethasone-dipropionate (BDP) with a breath-actuated inhaler (BAI). Results The median fall in FEV0.5/1 after 200 μg BDP was significantly reduced from 30.9% at baseline to 16.0% (P < 0.001). Twenty children (64.5%) showed a good response to 200 μg BDP (≥50% decrease in fall of FEV0.5/1), while 8 children showed a moderate response (25–50%), and three children showed no response at all (< 25%). Conclusion A low single dose ICS offers acute protection against EIB in the majority of asthmatic children not currently treated with inhaled corticosteroids

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