Protein Corona Mediated Stealth Properties of Biocompatible Carbohydrate-based Nanocarriers

Johanna Simon, Sarah Christmann, Volker Mailänder, Frederik R. Wurm, Katharina Landfester*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Abstract

Carbohydrates possess ideal properties for the synthesis of biocompatible nanocarriers. Therefore, hydroxyethyl starch was chosen as building material to produce biodegradable nanocarriers allowing the encapsulation of drugs. A mandatory feature for the successful application of nanocarriers in drug delivery is to avoid non-specific uptake into macrophages. Todays’ gold standard is poly(ethylene glycol) (PEG) attached onto the surface of nanocarriers. As alternatives, we synthesize completely carbohydrate-based nanocarriers by functionalizing the surface with different sugar derivatives (hydroxyethyl starch, dextran, or glucose) via copper-free click reaction. Studying the interaction of sugar-modified nanocarriers and plasma proteins indicates a strong enrichment of adsorbed ‘stealth’ proteins (clusterin) which are also identified on PEGylated nanocarriers. Cellular uptake studies proved that there is no unspecific interaction between carbohydrate- modified nanocarriers and phagocytic cells, herby underlining the stealth properties.

Original languageEnglish
Pages (from-to)1363-1372
Number of pages10
JournalIsrael journal of chemistry
Volume58
Issue number12
DOIs
Publication statusPublished - Dec 2018
Externally publishedYes

Keywords

  • carbohydrates
  • clusterin
  • immune cells
  • nanocapsules
  • protein corona
  • Stealth effect

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