Protein release from injectable stereocomplexed hydrogels based on PEG-PDLA and PEG-PLLA star block copolymers

W.E. Hennink; C. Hiemstra; Zhiyuan Zhong; J. Feijen; T Sam; S.R. van Tomme; Pieter J. Dijkstra; Jan Feijen

doi:10.1016/j.jconrel.2006.09.028

Protein release from injectable stereocomplexed hydrogels based on PEG-PDLA and PEG-PLLA star block copolymers

W.E. Hennink (Editor), C. Hiemstra, Zhiyuan Zhong, J. Feijen (Editor), T Sam (Editor), S.R. van Tomme, Pieter J. Dijkstra, Jan Feijen

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Abstract

The release of two model proteins, lysozyme and immunoglobulin G (IgG) from injectable, fast gelling, biodegradable hydrogels composed of PEG–PLLA and PEG–PDLA star block copolymers was investigated. Lysozyme was quantitatively released in 10 days. The release of IgG was slower and after 20 days 40–60% was released depending on the composition of the gel.

Original language	Undefined
Pages	19-21
DOIs	https://doi.org/10.1016/j.jconrel.2006.09.028
Publication status	Published - 5 Apr 2006
Event	9th European Symposium on Controlled Drug Delivery, ESCDD 2006 - Noordwijk aan Zee, Netherlands Duration: 5 Apr 2006 → 7 Apr 2006 Conference number: 9

Conference

Conference	9th European Symposium on Controlled Drug Delivery, ESCDD 2006
Abbreviated title	ESCDD
Country/Territory	Netherlands
City	Noordwijk aan Zee
Period	5/04/06 → 7/04/06

Keywords

METIS-236892
IR-71107

Access to Document

10.1016/j.jconrel.2006.09.028

Cite this

Hennink, W. E. (Ed.), Hiemstra, C., Zhong, Z., Feijen, J. (Ed.), Sam, T. (Ed.), van Tomme, S. R., Dijkstra, P. J., & Feijen, J. (2006). Protein release from injectable stereocomplexed hydrogels based on PEG-PDLA and PEG-PLLA star block copolymers. 19-21. Paper presented at 9th European Symposium on Controlled Drug Delivery, ESCDD 2006, Noordwijk aan Zee, Netherlands. https://doi.org/10.1016/j.jconrel.2006.09.028

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title = "Protein release from injectable stereocomplexed hydrogels based on PEG-PDLA and PEG-PLLA star block copolymers",

abstract = "The release of two model proteins, lysozyme and immunoglobulin G (IgG) from injectable, fast gelling, biodegradable hydrogels composed of PEG–PLLA and PEG–PDLA star block copolymers was investigated. Lysozyme was quantitatively released in 10 days. The release of IgG was slower and after 20 days 40–60% was released depending on the composition of the gel.",

keywords = "METIS-236892, IR-71107",

author = "W.E. Hennink and C. Hiemstra and Zhiyuan Zhong and J. Feijen and T Sam and {van Tomme}, S.R. and Dijkstra, {Pieter J.} and Jan Feijen",

note = "Proceedings of the Ninth European Symposium on Controlled Drug Delivery ; 9th European Symposium on Controlled Drug Delivery, ESCDD 2006 ; Conference date: 05-04-2006 Through 07-04-2006",

year = "2006",

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day = "5",

doi = "10.1016/j.jconrel.2006.09.028",

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Hennink, WE (ed.), Hiemstra, C, Zhong, Z, Feijen, J (ed.), Sam, T (ed.), van Tomme, SR, Dijkstra, PJ & Feijen, J 2006, 'Protein release from injectable stereocomplexed hydrogels based on PEG-PDLA and PEG-PLLA star block copolymers', Paper presented at 9th European Symposium on Controlled Drug Delivery, ESCDD 2006, Noordwijk aan Zee, Netherlands, 5/04/06 - 7/04/06 pp. 19-21. https://doi.org/10.1016/j.jconrel.2006.09.028

TY - CONF

T1 - Protein release from injectable stereocomplexed hydrogels based on PEG-PDLA and PEG-PLLA star block copolymers

AU - Hiemstra, C.

AU - Zhong, Zhiyuan

AU - van Tomme, S.R.

AU - Dijkstra, Pieter J.

AU - Feijen, Jan

A2 - Hennink, W.E.

A2 - Feijen, J.

A2 - Sam, T

N1 - Conference code: 9

PY - 2006/4/5

Y1 - 2006/4/5

N2 - The release of two model proteins, lysozyme and immunoglobulin G (IgG) from injectable, fast gelling, biodegradable hydrogels composed of PEG–PLLA and PEG–PDLA star block copolymers was investigated. Lysozyme was quantitatively released in 10 days. The release of IgG was slower and after 20 days 40–60% was released depending on the composition of the gel.

AB - The release of two model proteins, lysozyme and immunoglobulin G (IgG) from injectable, fast gelling, biodegradable hydrogels composed of PEG–PLLA and PEG–PDLA star block copolymers was investigated. Lysozyme was quantitatively released in 10 days. The release of IgG was slower and after 20 days 40–60% was released depending on the composition of the gel.

KW - METIS-236892

KW - IR-71107

U2 - 10.1016/j.jconrel.2006.09.028

DO - 10.1016/j.jconrel.2006.09.028

M3 - Paper

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EP - 21

T2 - 9th European Symposium on Controlled Drug Delivery, ESCDD 2006

Y2 - 5 April 2006 through 7 April 2006

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