Protein–Polymer Dynamics as Affected by Polymer Coating and Interactions

D. Russo*, A. De Angelis, A. Paciaroni, B. Frick, N. de Sousa, F. R. Wurm, J. Teixeira

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)


We investigate the relaxation dynamics of protein–polymer conjugates by neutron scattering spectroscopy to understand to which extent the coating of a protein by a polymer can replace water in promoting thermal structural fluctuations. For this purpose, we compare the dynamics of protein–polymer mixtures to that of conjugates with a variable number of polymers covalently attached to the protein. Results show that the flexibility of the protein is larger in protein–polymer mixtures than in native protein or in conjugates, even in the dry state. Upon hydration, both the native protein and the conjugate show equivalent dynamics, suggesting that the polymer grafted on the protein surface adsorbs all water molecules.
Original languageEnglish
Pages (from-to)2674-2679
Issue number7
Publication statusPublished - 19 Feb 2019
Externally publishedYes


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