PTMC based nanoparticles as biodegradable carriers for controlled drug release

Z. Zhang; M. A. Foks; D. W. Grijpma; J. Feijen

PTMC based nanoparticles as biodegradable carriers for controlled drug release

Z. Zhang^*, M. A. Foks, D. W. Grijpma, J. Feijen

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

Abstract

The advantage of using poly(trimethylene carbonate) (PTMC) based nanoparticles as biodegradable carriers for controlled drug release was investigated. PTMC₅₀ and monomethoxy poly(ethylene glycol) (mPEG) were prepared by ring opening polymerization of TMC using hexanol or mPEG ₃ as an initiator and stannous octoate as a catalyst. The particle size was found to decrease with an increase in stirring speed. The results show that these polymers degrade enzymatically.

Original language	English
Title of host publication	Transactions - 7th World Biomaterials Congress
Pages	669
Number of pages	1
Publication status	Published - 1 Dec 2004
Event	7th World Biomaterials Congress, WBC 2004 - Sydney, Australia Duration: 17 May 2004 → 21 May 2004 Conference number: 7

Conference

Conference	7th World Biomaterials Congress, WBC 2004
Abbreviated title	WBC
Country/Territory	Australia
City	Sydney
Period	17/05/04 → 21/05/04

Cite this

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title = "PTMC based nanoparticles as biodegradable carriers for controlled drug release",

abstract = "The advantage of using poly(trimethylene carbonate) (PTMC) based nanoparticles as biodegradable carriers for controlled drug release was investigated. PTMC50 and monomethoxy poly(ethylene glycol) (mPEG) were prepared by ring opening polymerization of TMC using hexanol or mPEG 3 as an initiator and stannous octoate as a catalyst. The particle size was found to decrease with an increase in stirring speed. The results show that these polymers degrade enzymatically.",

author = "Z. Zhang and Foks, {M. A.} and Grijpma, {D. W.} and J. Feijen",

year = "2004",

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T1 - PTMC based nanoparticles as biodegradable carriers for controlled drug release

AU - Zhang, Z.

AU - Foks, M. A.

AU - Grijpma, D. W.

AU - Feijen, J.

N1 - Conference code: 7

PY - 2004/12/1

Y1 - 2004/12/1

N2 - The advantage of using poly(trimethylene carbonate) (PTMC) based nanoparticles as biodegradable carriers for controlled drug release was investigated. PTMC50 and monomethoxy poly(ethylene glycol) (mPEG) were prepared by ring opening polymerization of TMC using hexanol or mPEG 3 as an initiator and stannous octoate as a catalyst. The particle size was found to decrease with an increase in stirring speed. The results show that these polymers degrade enzymatically.

AB - The advantage of using poly(trimethylene carbonate) (PTMC) based nanoparticles as biodegradable carriers for controlled drug release was investigated. PTMC50 and monomethoxy poly(ethylene glycol) (mPEG) were prepared by ring opening polymerization of TMC using hexanol or mPEG 3 as an initiator and stannous octoate as a catalyst. The particle size was found to decrease with an increase in stirring speed. The results show that these polymers degrade enzymatically.

UR - http://www.scopus.com/inward/record.url?scp=13844276068&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:13844276068

SN - 1877040193

SN - 9781877040191

SP - 669

BT - Transactions - 7th World Biomaterials Congress

T2 - 7th World Biomaterials Congress, WBC 2004

Y2 - 17 May 2004 through 21 May 2004

ER -

PTMC based nanoparticles as biodegradable carriers for controlled drug release

Abstract

Conference

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