PTMC based nanoparticles as biodegradable carriers for controlled drug release

Z. Zhang*, M. A. Foks, D. W. Grijpma, J. Feijen

*Corresponding author for this work

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

    Abstract

    The advantage of using poly(trimethylene carbonate) (PTMC) based nanoparticles as biodegradable carriers for controlled drug release was investigated. PTMC50 and monomethoxy poly(ethylene glycol) (mPEG) were prepared by ring opening polymerization of TMC using hexanol or mPEG 3 as an initiator and stannous octoate as a catalyst. The particle size was found to decrease with an increase in stirring speed. The results show that these polymers degrade enzymatically.

    Original languageEnglish
    Title of host publicationTransactions - 7th World Biomaterials Congress
    Pages669
    Number of pages1
    Publication statusPublished - 1 Dec 2004
    Event7th World Biomaterials Congress, WBC 2004 - Sydney, Australia
    Duration: 17 May 200421 May 2004
    Conference number: 7

    Conference

    Conference7th World Biomaterials Congress, WBC 2004
    Abbreviated titleWBC
    CountryAustralia
    CitySydney
    Period17/05/0421/05/04

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