Pulsed photoacoustic flow imaging with a handheld system

P.J. van den Berg, Khalid Daoudi, Wiendelt Steenbergen

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)
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Abstract

Flow imaging is an important technique in a range of disease areas, but estimating low flow speeds, especially near the walls of blood vessels, remains challenging. Pulsed photoacoustic flow imaging can be an alternative since there is little signal contamination from background tissue with photoacoustic imaging. We propose flow imaging using a clinical photoacoustic system that is both handheld and portable. The system integrates a linear array with 7.5 MHz central frequency in combination with a high-repetition-rate diode laser to allow high-speed photoacoustic imaging—ideal for this application. This work shows the flow imaging performance of the system in vitro using microparticles. Both two-dimensional (2-D) flow images and quantitative flow velocities from 12 to 75  mm/s 75  mm/s were obtained. In a transparent bulk medium, flow estimation showed standard errors of ∼7% ∼7% the estimated speed; in the presence of tissue-realistic optical scattering, the error increased to 40% due to limited signal-to-noise ratio. In the future, photoacoustic flow imaging can potentially be performed in vivo using fluorophore-filled vesicles or with an improved setup on whole blood
Original languageEnglish
Article number026004
Pages (from-to)026004-
JournalJournal of biomedical optics
Volume21
Issue number2
DOIs
Publication statusPublished - 2016

Fingerprint

Photoacoustic effect
Imaging techniques
Tissue
Fluorophores
Blood vessels
Flow velocity
Semiconductor lasers
blood vessels
Signal to noise ratio
microparticles
Contamination
linear arrays
Blood
Scattering
blood
repetition
contamination
signal to noise ratios
estimating
flow velocity

Keywords

  • METIS-315467
  • IR-100106

Cite this

van den Berg, P.J. ; Daoudi, Khalid ; Steenbergen, Wiendelt. / Pulsed photoacoustic flow imaging with a handheld system. In: Journal of biomedical optics. 2016 ; Vol. 21, No. 2. pp. 026004-.
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Pulsed photoacoustic flow imaging with a handheld system. / van den Berg, P.J.; Daoudi, Khalid; Steenbergen, Wiendelt.

In: Journal of biomedical optics, Vol. 21, No. 2, 026004, 2016, p. 026004-.

Research output: Contribution to journalArticleAcademicpeer-review

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AU - Daoudi, Khalid

AU - Steenbergen, Wiendelt

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AB - Flow imaging is an important technique in a range of disease areas, but estimating low flow speeds, especially near the walls of blood vessels, remains challenging. Pulsed photoacoustic flow imaging can be an alternative since there is little signal contamination from background tissue with photoacoustic imaging. We propose flow imaging using a clinical photoacoustic system that is both handheld and portable. The system integrates a linear array with 7.5 MHz central frequency in combination with a high-repetition-rate diode laser to allow high-speed photoacoustic imaging—ideal for this application. This work shows the flow imaging performance of the system in vitro using microparticles. Both two-dimensional (2-D) flow images and quantitative flow velocities from 12 to 75  mm/s 75  mm/s were obtained. In a transparent bulk medium, flow estimation showed standard errors of ∼7% ∼7% the estimated speed; in the presence of tissue-realistic optical scattering, the error increased to 40% due to limited signal-to-noise ratio. In the future, photoacoustic flow imaging can potentially be performed in vivo using fluorophore-filled vesicles or with an improved setup on whole blood

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