Pushing the Limits of Electrical Detection of Ultralow Flows in Nanofluidic Channels

Klaus Mathwig, Serge Joseph Guy Lemay

    Research output: Contribution to journalArticleAcademicpeer-review

    20 Citations (Scopus)
    80 Downloads (Pure)


    This paper presents improvements in flow detection by electrical cross-correlation spectroscopy. This new technique detects molecular number fluctuations of electrochemically active analyte molecules as they are transported by liquid flow through a nanochannel. The fluctuations are used as a marker of liquid flow as their time of flight in between two consecutive transducers is determined, thereby allowing for the measurement of liquid flow rates in the picoliter-per-minute regime. Here we show an enhanced record-low sensitivity below 1 pL/min by capitalizing on improved electrical instrumentation, an optimized sensor geometry and a smaller channel cross section. We further discuss the impact of sensor geometry on the cross-correlation functions.
    Original languageEnglish
    Pages (from-to)138-148
    Issue number2
    Publication statusPublished - 2013
    Event1st International Conference on MicroFluidic Handling Systems, MFHS 2012 - Enschede, Netherlands
    Duration: 10 Oct 201212 Oct 2012
    Conference number: 1


    • METIS-298689
    • IR-90032


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