Quantification in dynamic and small-animal positron emission tomography

Johannes Antonius Disselhorst

Research output: ThesisPhD Thesis - Research external, graduation UTAcademic

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Abstract

This thesis covers two aspects of positron emission tomography (PET) quantification. The first section addresses the characterization and optimization of a small-animal PET/CT scanner. The sensitivity and resolution as well as various parameters affecting image quality (reconstruction settings, type of radionuclide) are assessed. In the second section of the thesis, dynamic PET acquisitions are considered. The influence of the framing schedule on the accuracy of the pharmacokinetic parameters is investigated, resulting in the development of an optimized schedule. Because a reduction in scan time would be advantageous for the implementation of dynamic PET in the clinic, the effects of this reduction are also studied. Finally, a study is presented demonstrating the potential of dynamic PET for identifying additional parameters related to the tumor microenvironment.
Original languageEnglish
Awarding Institution
  • University of Twente
Supervisors/Advisors
  • Slump, Cornelis H., Supervisor
  • Oyen, Wim J.G., Supervisor, External person
  • de Geus-Oei, Lioe-Fee , Co-Supervisor
  • Visser, E.P., Co-Supervisor
Award date14 Dec 2011
Place of PublicationEnschede
Publisher
Print ISBNs978-90-365-3270-9
DOIs
Publication statusPublished - 14 Dec 2011

Fingerprint

animals
positrons
tomography
theses
schedules
radioactive isotopes
scanners
acquisition
tumors
optimization
sensitivity

Keywords

  • Positron emission tomography (PET) quantification
  • EWI-21532
  • PET scanner
  • METIS-285140
  • IR-78858
  • Medical maging

Cite this

Disselhorst, Johannes Antonius. / Quantification in dynamic and small-animal positron emission tomography. Enschede : Twente University Press (TUP), 2011. 137 p.
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Quantification in dynamic and small-animal positron emission tomography. / Disselhorst, Johannes Antonius.

Enschede : Twente University Press (TUP), 2011. 137 p.

Research output: ThesisPhD Thesis - Research external, graduation UTAcademic

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