Quantification in dynamic and small-animal positron emission tomography

Johannes Antonius Disselhorst

doi:10.3990/1.9789036532709

Quantification in dynamic and small-animal positron emission tomography

Johannes Antonius Disselhorst

Research output: Thesis › PhD Thesis - Research external, graduation UT

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Abstract

This thesis covers two aspects of positron emission tomography (PET) quantification. The first section addresses the characterization and optimization of a small-animal PET/CT scanner. The sensitivity and resolution as well as various parameters affecting image quality (reconstruction settings, type of radionuclide) are assessed. In the second section of the thesis, dynamic PET acquisitions are considered. The influence of the framing schedule on the accuracy of the pharmacokinetic parameters is investigated, resulting in the development of an optimized schedule. Because a reduction in scan time would be advantageous for the implementation of dynamic PET in the clinic, the effects of this reduction are also studied. Finally, a study is presented demonstrating the potential of dynamic PET for identifying additional parameters related to the tumor microenvironment.

Original language	English
Awarding Institution	University of Twente
Supervisors/Advisors	Slump, C.A., Supervisor Oyen, Wim J.G., Supervisor, External person Oei, Lioe-Fee, Co-Supervisor Visser, Eric P., Co-Supervisor, External person
Award date	14 Dec 2011
Place of Publication	Enschede
Publisher	Twente University Press (TUP)
Print ISBNs	978-90-365-3270-9
DOIs	https://doi.org/10.3990/1.9789036532709
Publication status	Published - 14 Dec 2011

Keywords

Positron emission tomography (PET) quantification
EWI-21532
PET scanner
METIS-285140
IR-78858
Medical maging

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title = "Quantification in dynamic and small-animal positron emission tomography",

abstract = "This thesis covers two aspects of positron emission tomography (PET) quantification. The first section addresses the characterization and optimization of a small-animal PET/CT scanner. The sensitivity and resolution as well as various parameters affecting image quality (reconstruction settings, type of radionuclide) are assessed. In the second section of the thesis, dynamic PET acquisitions are considered. The influence of the framing schedule on the accuracy of the pharmacokinetic parameters is investigated, resulting in the development of an optimized schedule. Because a reduction in scan time would be advantageous for the implementation of dynamic PET in the clinic, the effects of this reduction are also studied. Finally, a study is presented demonstrating the potential of dynamic PET for identifying additional parameters related to the tumor microenvironment.",

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N2 - This thesis covers two aspects of positron emission tomography (PET) quantification. The first section addresses the characterization and optimization of a small-animal PET/CT scanner. The sensitivity and resolution as well as various parameters affecting image quality (reconstruction settings, type of radionuclide) are assessed. In the second section of the thesis, dynamic PET acquisitions are considered. The influence of the framing schedule on the accuracy of the pharmacokinetic parameters is investigated, resulting in the development of an optimized schedule. Because a reduction in scan time would be advantageous for the implementation of dynamic PET in the clinic, the effects of this reduction are also studied. Finally, a study is presented demonstrating the potential of dynamic PET for identifying additional parameters related to the tumor microenvironment.

AB - This thesis covers two aspects of positron emission tomography (PET) quantification. The first section addresses the characterization and optimization of a small-animal PET/CT scanner. The sensitivity and resolution as well as various parameters affecting image quality (reconstruction settings, type of radionuclide) are assessed. In the second section of the thesis, dynamic PET acquisitions are considered. The influence of the framing schedule on the accuracy of the pharmacokinetic parameters is investigated, resulting in the development of an optimized schedule. Because a reduction in scan time would be advantageous for the implementation of dynamic PET in the clinic, the effects of this reduction are also studied. Finally, a study is presented demonstrating the potential of dynamic PET for identifying additional parameters related to the tumor microenvironment.

KW - Positron emission tomography (PET) quantification

KW - EWI-21532

KW - PET scanner

KW - METIS-285140

KW - IR-78858

KW - Medical maging

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PB - Twente University Press (TUP)

CY - Enschede

ER -

Quantification in dynamic and small-animal positron emission tomography

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