Quantification of cutaneous allergic reactions using 3D optical imaging: A feasibility study

Mark D. den Blanken, Sebastiaan van der Bent, Niels Liberton, Matthijs Grimbergen, Mark B.M. Hofman, Ruud Verdaasdonk, Thomas Rustemeyer

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background: User-independent quantitative measures of cutaneous allergic reactions can help the physicians manage and evaluate the treatment of cutaneous allergic reactions. In this paper, we present and validate a method to quantify the elevation, volume and area of cutaneous allergic reactions to red tattoos. Methods: The skin surface of allergic tattoo reactions was imaged using an optical 3D scanner. The in-house developed analysis tool measured the elevation, volume and area of the lesions, compared to a reference surface. This reference surface was created by 3D interpolation of the skin after manual removal of the lesions. The error of the interpolation tool was validated using a digital arm model. The error of our optical scanner was determined using a 3D printed lesion phantom. The clinical feasibility of the method was tested in 83 lesions in 17 patients. Results: The method showed clear potential to assess skin elevation, volume change and area of an allergic reaction. The validation measurements revealed that the error due to interpolation increases for larger interpolation areas and largely determined the error in the clinical measurements. Lesions with a width ≥4 mm and an elevation ≥0.4 mm could be measured with an error below 26%. Patient measurements showed that lesions up to 600 mm2 could be measured accurately, and elevation and volume changes could be assessed at follow-up. Conclusion: Quantification of cutaneous allergic reactions to red tattoos using 3D optical scanning is feasible and may objectify skin elevation and improve management of the allergic reaction.

Original languageEnglish
JournalSkin research and technology
DOIs
Publication statusE-pub ahead of print/First online - 18 Aug 2019

Fingerprint

Optical Imaging
Feasibility Studies
Hypersensitivity
Skin
Physicians

Keywords

  • UT-Hybrid-D
  • allergic reaction
  • elevation
  • lichenoid
  • optical scanner
  • phantom
  • red
  • skin
  • tattoo ink
  • volume
  • 3D scanner

Cite this

den Blanken, M. D., van der Bent, S., Liberton, N., Grimbergen, M., Hofman, M. B. M., Verdaasdonk, R., & Rustemeyer, T. (2019). Quantification of cutaneous allergic reactions using 3D optical imaging: A feasibility study. Skin research and technology. https://doi.org/10.1111/srt.12765
den Blanken, Mark D. ; van der Bent, Sebastiaan ; Liberton, Niels ; Grimbergen, Matthijs ; Hofman, Mark B.M. ; Verdaasdonk, Ruud ; Rustemeyer, Thomas. / Quantification of cutaneous allergic reactions using 3D optical imaging : A feasibility study. In: Skin research and technology. 2019.
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title = "Quantification of cutaneous allergic reactions using 3D optical imaging: A feasibility study",
abstract = "Background: User-independent quantitative measures of cutaneous allergic reactions can help the physicians manage and evaluate the treatment of cutaneous allergic reactions. In this paper, we present and validate a method to quantify the elevation, volume and area of cutaneous allergic reactions to red tattoos. Methods: The skin surface of allergic tattoo reactions was imaged using an optical 3D scanner. The in-house developed analysis tool measured the elevation, volume and area of the lesions, compared to a reference surface. This reference surface was created by 3D interpolation of the skin after manual removal of the lesions. The error of the interpolation tool was validated using a digital arm model. The error of our optical scanner was determined using a 3D printed lesion phantom. The clinical feasibility of the method was tested in 83 lesions in 17 patients. Results: The method showed clear potential to assess skin elevation, volume change and area of an allergic reaction. The validation measurements revealed that the error due to interpolation increases for larger interpolation areas and largely determined the error in the clinical measurements. Lesions with a width ≥4 mm and an elevation ≥0.4 mm could be measured with an error below 26{\%}. Patient measurements showed that lesions up to 600 mm2 could be measured accurately, and elevation and volume changes could be assessed at follow-up. Conclusion: Quantification of cutaneous allergic reactions to red tattoos using 3D optical scanning is feasible and may objectify skin elevation and improve management of the allergic reaction.",
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den Blanken, MD, van der Bent, S, Liberton, N, Grimbergen, M, Hofman, MBM, Verdaasdonk, R & Rustemeyer, T 2019, 'Quantification of cutaneous allergic reactions using 3D optical imaging: A feasibility study' Skin research and technology. https://doi.org/10.1111/srt.12765

Quantification of cutaneous allergic reactions using 3D optical imaging : A feasibility study. / den Blanken, Mark D.; van der Bent, Sebastiaan; Liberton, Niels; Grimbergen, Matthijs; Hofman, Mark B.M.; Verdaasdonk, Ruud; Rustemeyer, Thomas.

In: Skin research and technology, 18.08.2019.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Quantification of cutaneous allergic reactions using 3D optical imaging

T2 - A feasibility study

AU - den Blanken, Mark D.

AU - van der Bent, Sebastiaan

AU - Liberton, Niels

AU - Grimbergen, Matthijs

AU - Hofman, Mark B.M.

AU - Verdaasdonk, Ruud

AU - Rustemeyer, Thomas

N1 - Wiley deal

PY - 2019/8/18

Y1 - 2019/8/18

N2 - Background: User-independent quantitative measures of cutaneous allergic reactions can help the physicians manage and evaluate the treatment of cutaneous allergic reactions. In this paper, we present and validate a method to quantify the elevation, volume and area of cutaneous allergic reactions to red tattoos. Methods: The skin surface of allergic tattoo reactions was imaged using an optical 3D scanner. The in-house developed analysis tool measured the elevation, volume and area of the lesions, compared to a reference surface. This reference surface was created by 3D interpolation of the skin after manual removal of the lesions. The error of the interpolation tool was validated using a digital arm model. The error of our optical scanner was determined using a 3D printed lesion phantom. The clinical feasibility of the method was tested in 83 lesions in 17 patients. Results: The method showed clear potential to assess skin elevation, volume change and area of an allergic reaction. The validation measurements revealed that the error due to interpolation increases for larger interpolation areas and largely determined the error in the clinical measurements. Lesions with a width ≥4 mm and an elevation ≥0.4 mm could be measured with an error below 26%. Patient measurements showed that lesions up to 600 mm2 could be measured accurately, and elevation and volume changes could be assessed at follow-up. Conclusion: Quantification of cutaneous allergic reactions to red tattoos using 3D optical scanning is feasible and may objectify skin elevation and improve management of the allergic reaction.

AB - Background: User-independent quantitative measures of cutaneous allergic reactions can help the physicians manage and evaluate the treatment of cutaneous allergic reactions. In this paper, we present and validate a method to quantify the elevation, volume and area of cutaneous allergic reactions to red tattoos. Methods: The skin surface of allergic tattoo reactions was imaged using an optical 3D scanner. The in-house developed analysis tool measured the elevation, volume and area of the lesions, compared to a reference surface. This reference surface was created by 3D interpolation of the skin after manual removal of the lesions. The error of the interpolation tool was validated using a digital arm model. The error of our optical scanner was determined using a 3D printed lesion phantom. The clinical feasibility of the method was tested in 83 lesions in 17 patients. Results: The method showed clear potential to assess skin elevation, volume change and area of an allergic reaction. The validation measurements revealed that the error due to interpolation increases for larger interpolation areas and largely determined the error in the clinical measurements. Lesions with a width ≥4 mm and an elevation ≥0.4 mm could be measured with an error below 26%. Patient measurements showed that lesions up to 600 mm2 could be measured accurately, and elevation and volume changes could be assessed at follow-up. Conclusion: Quantification of cutaneous allergic reactions to red tattoos using 3D optical scanning is feasible and may objectify skin elevation and improve management of the allergic reaction.

KW - UT-Hybrid-D

KW - allergic reaction

KW - elevation

KW - lichenoid

KW - optical scanner

KW - phantom

KW - red

KW - skin

KW - tattoo ink

KW - volume

KW - 3D scanner

U2 - 10.1111/srt.12765

DO - 10.1111/srt.12765

M3 - Article

JO - Skin research and technology

JF - Skin research and technology

SN - 0909-752X

ER -

den Blanken MD, van der Bent S, Liberton N, Grimbergen M, Hofman MBM, Verdaasdonk R et al. Quantification of cutaneous allergic reactions using 3D optical imaging: A feasibility study. Skin research and technology. 2019 Aug 18. https://doi.org/10.1111/srt.12765