Quantification of macrocirculation and microcirculation in brain using ultrasound perfusion imaging

Eline J. Vinke, Jens Eyding, Chris de Korte, Cornelis H. Slump, Johannes G. van der Hoeven, Cornelia W.E. Hoedemaekers*

*Corresponding author for this work

    Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

    3 Citations (Scopus)

    Abstract

    Objective: The aim of this study was to investigate the feasibility of simultaneous visualization of the cerebral macrocirculation and microcirculation, using ultrasound perfusion imaging (UPI). In addition, we studied the sensitivity of this technique for detecting changes in cerebral blood flow (CBF). Materials and methods: We performed an observational study in ten healthy volunteers. Ultrasound contrast was used for UPI measurements during normoventilation and hyperventilation. For the data analysis of the UPI measurements, an in-house algorithm was used to visualize the DICOM files, calculate parameter images and select regions of interest (ROIs). Next, time intensity curves (TIC) were extracted and perfusion parameters calculated. Results: Both volume- and velocity-related perfusion parameters were significantly different between the macrocirculation and the parenchymal areas. Hyperventilation-induced decreases in CBF were detectable by UPI in both the macrocirculation and microcirculation, most consistently by the volume-related parameters. The method was safe, with no adverse effects in our population. Conclusions: Bedside quantification of CBF seems feasible and the technique has a favourable safety profile. Adjustment of current method is required to improve its diagnostic accuracy. Validation studies using a ‘gold standard’ are needed to determine the added value of UPI in neurocritical care monitoring.

    Original languageEnglish
    Title of host publicationIntracranial Pressure & Neuromonitoring XVI
    EditorsThomas Heldt
    PublisherSpringer
    Pages115-120
    Number of pages6
    ISBN (Electronic)978-3-319-65798-1
    ISBN (Print)978-3-319-65797-4
    DOIs
    Publication statusPublished - 1 Mar 2018

    Publication series

    NameActa Neurochirurgica Supplement
    Volume126
    ISSN (Print)0065-1419
    ISSN (Electronic)2197-8395

    Keywords

    • Acute brain injury
    • Cerebral blood flow
    • Contrast enhanced ultrasound
    • Intensive care
    • Ischemia

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