Quantification of macrocirculation and microcirculation in brain using ultrasound perfusion imaging

Eline J. Vinke, Jens Eyding, Chris de Korte, Cornelis H. Slump, Johannes G. van der Hoeven, Cornelia W.E. Hoedemaekers

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Abstract

Objective: The aim of this study was to investigate the feasibility of simultaneous visualization of the cerebral macrocirculation and microcirculation, using ultrasound perfusion imaging (UPI). In addition, we studied the sensitivity of this technique for detecting changes in cerebral blood flow (CBF). Materials and methods: We performed an observational study in ten healthy volunteers. Ultrasound contrast was used for UPI measurements during normoventilation and hyperventilation. For the data analysis of the UPI measurements, an in-house algorithm was used to visualize the DICOM files, calculate parameter images and select regions of interest (ROIs). Next, time intensity curves (TIC) were extracted and perfusion parameters calculated. Results: Both volume- and velocity-related perfusion parameters were significantly different between the macrocirculation and the parenchymal areas. Hyperventilation-induced decreases in CBF were detectable by UPI in both the macrocirculation and microcirculation, most consistently by the volume-related parameters. The method was safe, with no adverse effects in our population. Conclusions: Bedside quantification of CBF seems feasible and the technique has a favourable safety profile. Adjustment of current method is required to improve its diagnostic accuracy. Validation studies using a ‘gold standard’ are needed to determine the added value of UPI in neurocritical care monitoring.

Original languageEnglish
Title of host publicationIntracranial Pressure & Neuromonitoring XVI
EditorsThomas Heldt
PublisherSpringer
Pages115-120
Number of pages6
ISBN (Electronic)978-3-319-65798-1
ISBN (Print)978-3-319-65797-4
DOIs
Publication statusPublished - 1 Mar 2018

Publication series

NameActa Neurochirurgica Supplement
Volume126
ISSN (Print)0065-1419
ISSN (Electronic)2197-8395

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Perfusion Imaging
Microcirculation
Cerebrovascular Circulation
Ultrasonography
Brain
Hyperventilation
Perfusion
Validation Studies
Observational Studies
Healthy Volunteers
Safety
Population

Keywords

  • Acute brain injury
  • Cerebral blood flow
  • Contrast enhanced ultrasound
  • Intensive care
  • Ischemia

Cite this

Vinke, E. J., Eyding, J., de Korte, C., Slump, C. H., van der Hoeven, J. G., & Hoedemaekers, C. W. E. (2018). Quantification of macrocirculation and microcirculation in brain using ultrasound perfusion imaging. In T. Heldt (Ed.), Intracranial Pressure & Neuromonitoring XVI (pp. 115-120). (Acta Neurochirurgica Supplement; Vol. 126). Springer. https://doi.org/10.1007/978-3-319-65798-1_25
Vinke, Eline J. ; Eyding, Jens ; de Korte, Chris ; Slump, Cornelis H. ; van der Hoeven, Johannes G. ; Hoedemaekers, Cornelia W.E. / Quantification of macrocirculation and microcirculation in brain using ultrasound perfusion imaging. Intracranial Pressure & Neuromonitoring XVI. editor / Thomas Heldt. Springer, 2018. pp. 115-120 (Acta Neurochirurgica Supplement).
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Vinke, EJ, Eyding, J, de Korte, C, Slump, CH, van der Hoeven, JG & Hoedemaekers, CWE 2018, Quantification of macrocirculation and microcirculation in brain using ultrasound perfusion imaging. in T Heldt (ed.), Intracranial Pressure & Neuromonitoring XVI. Acta Neurochirurgica Supplement, vol. 126, Springer, pp. 115-120. https://doi.org/10.1007/978-3-319-65798-1_25

Quantification of macrocirculation and microcirculation in brain using ultrasound perfusion imaging. / Vinke, Eline J.; Eyding, Jens; de Korte, Chris; Slump, Cornelis H.; van der Hoeven, Johannes G.; Hoedemaekers, Cornelia W.E.

Intracranial Pressure & Neuromonitoring XVI. ed. / Thomas Heldt. Springer, 2018. p. 115-120 (Acta Neurochirurgica Supplement; Vol. 126).

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

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T1 - Quantification of macrocirculation and microcirculation in brain using ultrasound perfusion imaging

AU - Vinke, Eline J.

AU - Eyding, Jens

AU - de Korte, Chris

AU - Slump, Cornelis H.

AU - van der Hoeven, Johannes G.

AU - Hoedemaekers, Cornelia W.E.

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KW - Acute brain injury

KW - Cerebral blood flow

KW - Contrast enhanced ultrasound

KW - Intensive care

KW - Ischemia

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M3 - Chapter

SN - 978-3-319-65797-4

T3 - Acta Neurochirurgica Supplement

SP - 115

EP - 120

BT - Intracranial Pressure & Neuromonitoring XVI

A2 - Heldt, Thomas

PB - Springer

ER -

Vinke EJ, Eyding J, de Korte C, Slump CH, van der Hoeven JG, Hoedemaekers CWE. Quantification of macrocirculation and microcirculation in brain using ultrasound perfusion imaging. In Heldt T, editor, Intracranial Pressure & Neuromonitoring XVI. Springer. 2018. p. 115-120. (Acta Neurochirurgica Supplement). https://doi.org/10.1007/978-3-319-65798-1_25