Quantification of macrocirculation and microcirculation in brain using ultrasound perfusion imaging

Eline J. Vinke, Jens Eyding, Chris de Korte, Cornelis H. Slump, Johannes G. van der Hoeven, Cornelia W.E. Hoedemaekers*

*Corresponding author for this work

    Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

    Abstract

    Objective: The aim of this study was to investigate the feasibility of simultaneous visualization of the cerebral macrocirculation and microcirculation, using ultrasound perfusion imaging (UPI). In addition, we studied the sensitivity of this technique for detecting changes in cerebral blood flow (CBF). Materials and methods: We performed an observational study in ten healthy volunteers. Ultrasound contrast was used for UPI measurements during normoventilation and hyperventilation. For the data analysis of the UPI measurements, an in-house algorithm was used to visualize the DICOM files, calculate parameter images and select regions of interest (ROIs). Next, time intensity curves (TIC) were extracted and perfusion parameters calculated. Results: Both volume- and velocity-related perfusion parameters were significantly different between the macrocirculation and the parenchymal areas. Hyperventilation-induced decreases in CBF were detectable by UPI in both the macrocirculation and microcirculation, most consistently by the volume-related parameters. The method was safe, with no adverse effects in our population. Conclusions: Bedside quantification of CBF seems feasible and the technique has a favourable safety profile. Adjustment of current method is required to improve its diagnostic accuracy. Validation studies using a ‘gold standard’ are needed to determine the added value of UPI in neurocritical care monitoring.

    Original languageEnglish
    Title of host publicationIntracranial Pressure & Neuromonitoring XVI
    EditorsThomas Heldt
    PublisherSpringer
    Pages115-120
    Number of pages6
    ISBN (Electronic)978-3-319-65798-1
    ISBN (Print)978-3-319-65797-4
    DOIs
    Publication statusPublished - 1 Mar 2018

    Publication series

    NameActa Neurochirurgica Supplement
    Volume126
    ISSN (Print)0065-1419
    ISSN (Electronic)2197-8395

    Fingerprint

    Perfusion Imaging
    Microcirculation
    Cerebrovascular Circulation
    Ultrasonography
    Brain
    Hyperventilation
    Perfusion
    Validation Studies
    Observational Studies
    Healthy Volunteers
    Safety
    Population

    Keywords

    • Acute brain injury
    • Cerebral blood flow
    • Contrast enhanced ultrasound
    • Intensive care
    • Ischemia

    Cite this

    Vinke, E. J., Eyding, J., de Korte, C., Slump, C. H., van der Hoeven, J. G., & Hoedemaekers, C. W. E. (2018). Quantification of macrocirculation and microcirculation in brain using ultrasound perfusion imaging. In T. Heldt (Ed.), Intracranial Pressure & Neuromonitoring XVI (pp. 115-120). (Acta Neurochirurgica Supplement; Vol. 126). Springer. https://doi.org/10.1007/978-3-319-65798-1_25
    Vinke, Eline J. ; Eyding, Jens ; de Korte, Chris ; Slump, Cornelis H. ; van der Hoeven, Johannes G. ; Hoedemaekers, Cornelia W.E. / Quantification of macrocirculation and microcirculation in brain using ultrasound perfusion imaging. Intracranial Pressure & Neuromonitoring XVI. editor / Thomas Heldt. Springer, 2018. pp. 115-120 (Acta Neurochirurgica Supplement).
    @inbook{22f8ca6890754e2baf0026d964746d74,
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    abstract = "Objective: The aim of this study was to investigate the feasibility of simultaneous visualization of the cerebral macrocirculation and microcirculation, using ultrasound perfusion imaging (UPI). In addition, we studied the sensitivity of this technique for detecting changes in cerebral blood flow (CBF). Materials and methods: We performed an observational study in ten healthy volunteers. Ultrasound contrast was used for UPI measurements during normoventilation and hyperventilation. For the data analysis of the UPI measurements, an in-house algorithm was used to visualize the DICOM files, calculate parameter images and select regions of interest (ROIs). Next, time intensity curves (TIC) were extracted and perfusion parameters calculated. Results: Both volume- and velocity-related perfusion parameters were significantly different between the macrocirculation and the parenchymal areas. Hyperventilation-induced decreases in CBF were detectable by UPI in both the macrocirculation and microcirculation, most consistently by the volume-related parameters. The method was safe, with no adverse effects in our population. Conclusions: Bedside quantification of CBF seems feasible and the technique has a favourable safety profile. Adjustment of current method is required to improve its diagnostic accuracy. Validation studies using a ‘gold standard’ are needed to determine the added value of UPI in neurocritical care monitoring.",
    keywords = "Acute brain injury, Cerebral blood flow, Contrast enhanced ultrasound, Intensive care, Ischemia",
    author = "Vinke, {Eline J.} and Jens Eyding and {de Korte}, Chris and Slump, {Cornelis H.} and {van der Hoeven}, {Johannes G.} and Hoedemaekers, {Cornelia W.E.}",
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    Vinke, EJ, Eyding, J, de Korte, C, Slump, CH, van der Hoeven, JG & Hoedemaekers, CWE 2018, Quantification of macrocirculation and microcirculation in brain using ultrasound perfusion imaging. in T Heldt (ed.), Intracranial Pressure & Neuromonitoring XVI. Acta Neurochirurgica Supplement, vol. 126, Springer, pp. 115-120. https://doi.org/10.1007/978-3-319-65798-1_25

    Quantification of macrocirculation and microcirculation in brain using ultrasound perfusion imaging. / Vinke, Eline J.; Eyding, Jens; de Korte, Chris; Slump, Cornelis H.; van der Hoeven, Johannes G.; Hoedemaekers, Cornelia W.E.

    Intracranial Pressure & Neuromonitoring XVI. ed. / Thomas Heldt. Springer, 2018. p. 115-120 (Acta Neurochirurgica Supplement; Vol. 126).

    Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

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    T1 - Quantification of macrocirculation and microcirculation in brain using ultrasound perfusion imaging

    AU - Vinke, Eline J.

    AU - Eyding, Jens

    AU - de Korte, Chris

    AU - Slump, Cornelis H.

    AU - van der Hoeven, Johannes G.

    AU - Hoedemaekers, Cornelia W.E.

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    Y1 - 2018/3/1

    N2 - Objective: The aim of this study was to investigate the feasibility of simultaneous visualization of the cerebral macrocirculation and microcirculation, using ultrasound perfusion imaging (UPI). In addition, we studied the sensitivity of this technique for detecting changes in cerebral blood flow (CBF). Materials and methods: We performed an observational study in ten healthy volunteers. Ultrasound contrast was used for UPI measurements during normoventilation and hyperventilation. For the data analysis of the UPI measurements, an in-house algorithm was used to visualize the DICOM files, calculate parameter images and select regions of interest (ROIs). Next, time intensity curves (TIC) were extracted and perfusion parameters calculated. Results: Both volume- and velocity-related perfusion parameters were significantly different between the macrocirculation and the parenchymal areas. Hyperventilation-induced decreases in CBF were detectable by UPI in both the macrocirculation and microcirculation, most consistently by the volume-related parameters. The method was safe, with no adverse effects in our population. Conclusions: Bedside quantification of CBF seems feasible and the technique has a favourable safety profile. Adjustment of current method is required to improve its diagnostic accuracy. Validation studies using a ‘gold standard’ are needed to determine the added value of UPI in neurocritical care monitoring.

    AB - Objective: The aim of this study was to investigate the feasibility of simultaneous visualization of the cerebral macrocirculation and microcirculation, using ultrasound perfusion imaging (UPI). In addition, we studied the sensitivity of this technique for detecting changes in cerebral blood flow (CBF). Materials and methods: We performed an observational study in ten healthy volunteers. Ultrasound contrast was used for UPI measurements during normoventilation and hyperventilation. For the data analysis of the UPI measurements, an in-house algorithm was used to visualize the DICOM files, calculate parameter images and select regions of interest (ROIs). Next, time intensity curves (TIC) were extracted and perfusion parameters calculated. Results: Both volume- and velocity-related perfusion parameters were significantly different between the macrocirculation and the parenchymal areas. Hyperventilation-induced decreases in CBF were detectable by UPI in both the macrocirculation and microcirculation, most consistently by the volume-related parameters. The method was safe, with no adverse effects in our population. Conclusions: Bedside quantification of CBF seems feasible and the technique has a favourable safety profile. Adjustment of current method is required to improve its diagnostic accuracy. Validation studies using a ‘gold standard’ are needed to determine the added value of UPI in neurocritical care monitoring.

    KW - Acute brain injury

    KW - Cerebral blood flow

    KW - Contrast enhanced ultrasound

    KW - Intensive care

    KW - Ischemia

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    DO - 10.1007/978-3-319-65798-1_25

    M3 - Chapter

    AN - SCOPUS:85042922899

    SN - 978-3-319-65797-4

    T3 - Acta Neurochirurgica Supplement

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    BT - Intracranial Pressure & Neuromonitoring XVI

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    Vinke EJ, Eyding J, de Korte C, Slump CH, van der Hoeven JG, Hoedemaekers CWE. Quantification of macrocirculation and microcirculation in brain using ultrasound perfusion imaging. In Heldt T, editor, Intracranial Pressure & Neuromonitoring XVI. Springer. 2018. p. 115-120. (Acta Neurochirurgica Supplement). https://doi.org/10.1007/978-3-319-65798-1_25