Quantitative assessment of daytime motor activity provides a responsive measure of functional decline in patients with Huntington's disease

J. P.P. van Vugt*, S. Siesling, K. K.E. Piet, A. H. Zwinderman, H. A.M. Middelkoop, J. J. van Hilten, R. A.C. Roos

*Corresponding author for this work

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    32 Citations (Scopus)

    Abstract

    Voluntary motor impairment is a functionally important aspect of Huntington's disease (HD). Therefore, quantitative assessment of disturbed voluntary movement might be important in follow-up. We investigated the relation between quantitatively assessed daytime motor activity and symptom severity in HD and evaluated whether assessment of daytime motor activity is a responsive measure in the follow-up of patients. Sixty-four consecutive HD patients and 67 age- and sex-matched healthy controls were studied. Daytime motor activity was recorded using a wrist-worn activity monitor that counts all movements during a period of five consecutive days. Patients were rated clinically for voluntary motor impairment, dyskinesias, posture & gait, depression, cognitive impairment and functional capacity. Follow-up was available from 40 patients (mean follow-up 2.0 years) and 29 controls (mean follow-up 5.9 years). Despite chorea, patients had less daytime motor activity than controls (P < 0.005). This hypokinesia correlated with impaired voluntary movements (r = 0.37; P < 0.01), disturbed posture & gait (r = 0.38; P < 0.005) and especially with reduced functional capacity (r = 0.51; P < 0.0005). During follow-up, hypokinesia remained unchanged in clinically stable patients, but became worse in those whose functional disability progressed (P < 0.005). Hypokinesia seems a core symptom of HD which is related to functional capacity. Actimetric assessment of hypokinesia is responsive to disease progression and can be used as an objective tool for follow-up.

    Original languageEnglish
    Pages (from-to)481-488
    Number of pages8
    JournalMovement disorders
    Volume16
    Issue number3
    DOIs
    Publication statusPublished - 1 May 2001

    Keywords

    • Activity monitoring
    • Follow-up
    • Functional capacity
    • Huntington's disease
    • Voluntary movement

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    van Vugt, J. P. P., Siesling, S., Piet, K. K. E., Zwinderman, A. H., Middelkoop, H. A. M., van Hilten, J. J., & Roos, R. A. C. (2001). Quantitative assessment of daytime motor activity provides a responsive measure of functional decline in patients with Huntington's disease. Movement disorders, 16(3), 481-488. https://doi.org/10.1002/mds.1097