Quantitative blood oxygen saturation imaging using combined photoacoustics and acousto-optics

Altaf Hussain, Wilhelmina Petersen, J.W. Staley, Erwin Hondebrink, Wiendelt Steenbergen

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

In photoacoustic spectroscopy (PAS), wavelength dependent optical attenuation of biological tissue presents a challenge to measure the absolute oxygen saturation of hemoglobin (sO 2). Here, we employ the combination of photoacoustics and acousto-optics (AO) at two optical wavelengths to achieve quantification, where AO serves as a sensor for the relative local fluence. We demonstrate that our method enables compensation of spatial as well as wavelength dependent fluence variations in PAS without a priori knowledge about the optical properties of the medium. The fluence compensated photoacoustic images at two excitation wavelengths are used to estimate the absolute oxygen saturation of blood in a spatially and spectroscopically heterogeneous phantom.
Original languageEnglish
Pages (from-to)1720-1723
Number of pages4
JournalOptics letters
Volume41
Issue number8
DOIs
Publication statusPublished - 2016

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acousto-optics
blood
saturation
fluence
photoacoustic spectroscopy
oxygen
wavelengths
hemoglobin
attenuation
optical properties
sensors
estimates
excitation

Keywords

  • METIS-316337
  • IR-101158

Cite this

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abstract = "In photoacoustic spectroscopy (PAS), wavelength dependent optical attenuation of biological tissue presents a challenge to measure the absolute oxygen saturation of hemoglobin (sO 2). Here, we employ the combination of photoacoustics and acousto-optics (AO) at two optical wavelengths to achieve quantification, where AO serves as a sensor for the relative local fluence. We demonstrate that our method enables compensation of spatial as well as wavelength dependent fluence variations in PAS without a priori knowledge about the optical properties of the medium. The fluence compensated photoacoustic images at two excitation wavelengths are used to estimate the absolute oxygen saturation of blood in a spatially and spectroscopically heterogeneous phantom.",
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Quantitative blood oxygen saturation imaging using combined photoacoustics and acousto-optics. / Hussain, Altaf; Petersen, Wilhelmina; Staley, J.W.; Hondebrink, Erwin; Steenbergen, Wiendelt.

In: Optics letters, Vol. 41, No. 8, 2016, p. 1720-1723.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - Quantitative blood oxygen saturation imaging using combined photoacoustics and acousto-optics

AU - Hussain, Altaf

AU - Petersen, Wilhelmina

AU - Staley, J.W.

AU - Hondebrink, Erwin

AU - Steenbergen, Wiendelt

N1 - Open access

PY - 2016

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AB - In photoacoustic spectroscopy (PAS), wavelength dependent optical attenuation of biological tissue presents a challenge to measure the absolute oxygen saturation of hemoglobin (sO 2). Here, we employ the combination of photoacoustics and acousto-optics (AO) at two optical wavelengths to achieve quantification, where AO serves as a sensor for the relative local fluence. We demonstrate that our method enables compensation of spatial as well as wavelength dependent fluence variations in PAS without a priori knowledge about the optical properties of the medium. The fluence compensated photoacoustic images at two excitation wavelengths are used to estimate the absolute oxygen saturation of blood in a spatially and spectroscopically heterogeneous phantom.

KW - METIS-316337

KW - IR-101158

U2 - 10.1364/OL.41.001720

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JF - Optics letters

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