Quantitative comparison of analysis methods for spectroscopic optical coherence tomography

Nienke Bosschaart, Ton van Leeuwen, Maurice C.G. Aalders, Dirk Faber

    Research output: Contribution to journalArticleAcademicpeer-review

    31 Citations (Scopus)


    pectroscopic optical coherence tomography (sOCT) enables the mapping of chromophore concentrations and image contrast enhancement in tissue. Acquisition of depth resolved spectra by sOCT requires analysis methods with optimal spectral/spatial resolution and spectral recovery. In this article, we quantitatively compare the available methods, i.e. the short time Fourier transform (STFT), wavelet transforms, the Wigner-Ville distribution and the dual window method through simulations in tissue-like media. We conclude that all methods suffer from the trade-off in spectral/spatial resolution, and that the STFT is the optimal method for the specific application of the localized quantification of hemoglobin concentration and oxygen saturation.
    Original languageEnglish
    Pages (from-to)2570-2584
    JournalBiomedical optics express
    Issue number11
    Publication statusPublished - 2013


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