Quantitative measurements of absorption spectra in scattering media by low-coherence spectroscopy

Nienke Bosschaart, Maurice C. Aalders, Dirk J. Faber, Jelmer J. Weda, Martin J.C. van Gemert, Ton van Leeuwen

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Low-coherence spectroscopy (LCS) is a spectroscopic method that allows for quantitative and localized assessment of absorption spectra by combining reflection spectroscopy with low-coherence interferometry. We describe absorption coefficient (µa) measurements by LCS in tissue simulating phantoms with varying scattering and absorbing properties. We used LCS in the 455–680 nm wavelength range with a spectral resolution of 8 nmto obtain µa spectra with ±0.5 mm−1 accuracy. We conclude that LCS is a promising technique for the in vivo determination of tissue chromophore concentrations.
Original languageEnglish
Pages (from-to)3746-3748
Number of pages3
JournalOptics letters
Issue number23
Publication statusPublished - 2009


  • METIS-261716
  • IR-71715

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