Quantitative photoacoustic integrating sphere (QPAIS) platform for absorption coefficient and Gruneisen parameter measurements: Demonstration with human blood

Y.Y. Villanueva, Erwin Hondebrink, Wilhelmina Petersen, Wiendelt Steenbergen

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)
110 Downloads (Pure)

Abstract

Quantitative photoacoustic imaging in biomedicine relies on accurate measurements of relevant material properties of target absorbers. Here, we present a method for simultaneous measurements of the absorption coefficient and Grüneisen parameter of small volume of liquid scattering and absorbing media using a coupled-integrating sphere system which we refer to as quantitative photoacoustic integrating sphere (QPAIS) platform. The derived equations do not require absolute magnitudes of optical energy and pressure values, only calibration of the setup using aqueous ink dilutions is necessary. As a demonstration, measurements with blood samples from various human donors are done at room and body temperatures using an incubator. Measured absorption coefficient values are consistent with known oxygen saturation dependence of blood absorption at 750 nm, whereas measured Grüneisen parameter values indicate variability among five different donors. An increasing Grüneisen parameter value with both hematocrit and temperature is observed. These observations are consistent with those reported in literature.
Original languageEnglish
Pages (from-to)9-15
Number of pages7
JournalPhotoacoustics
Volume6
DOIs
Publication statusPublished - 2017

Keywords

  • METIS-322064
  • IR-104630

Fingerprint Dive into the research topics of 'Quantitative photoacoustic integrating sphere (QPAIS) platform for absorption coefficient and Gruneisen parameter measurements: Demonstration with human blood'. Together they form a unique fingerprint.

  • Cite this