TY - JOUR
T1 - Radiofrequency localization of nonpalpable breast cancer in a multicentre prospective cohort study
T2 - feasibility, clinical acceptability, and safety
AU - Christenhusz, Anke
AU - den Dekker, Bianca M.
AU - van Dalen, Thijs
AU - Jongen, Lisa
AU - van der Schaaf, Margreet C.
AU - Alic, Lejla
AU - ten Haken, Bennie
AU - Pijnappel, Ruud M.
AU - Dassen, Anneriet E.
N1 - Funding Information:
This work was supported by Hologic, grant number 1257. Hologic is not involved in the design of the study and collection, analysis, interpretation of data, writing the manuscript and in the decision to publish study results.
Publisher Copyright:
© 2023, The Author(s).
PY - 2023/8/1
Y1 - 2023/8/1
N2 - Purpose: In breast conserving surgery, accurate lesion localization is essential for obtaining adequate surgical margins. Preoperative wire localization (WL) and radioactive seed localization (RSL) are widely accepted methods to guide surgical excision of nonpalpable breast lesions but are limited by logistical challenges, migration issues, and legislative complexities. Radiofrequency identification (RFID) technology may offer a viable alternative. The purpose of this study was to evaluate the feasibility, clinical acceptability, and safety of RFID surgical guidance for localization of nonpalpable breast cancer.Methods: In a prospective multicentre cohort study, the first 100 RFID localization procedures were included. The primary outcome was the percentage of clear resection margins and re-excision rate. Secondary outcomes included procedure details, user experience, learningcurve, and adverse events.Results: Between April 2019 and May 2021, 100 women underwent RFID guided breast conserving surgery. Clear resection margins were obtained in 89 out of 96 included patients (92.7%), re-excision was indicated in three patients (3.1%). Radiologists reported difficulties with the placement of the RFID tag, partially related to the relatively large needle-applicator (12-gauge). This led to the premature termination of the study in the hospital using RSL as regular care. The radiologist experience was improved after a manufacturer modification of the needle-applicator. Surgical localization involved a low learning curve. Adverse events (n = 33) included dislocation of the marker during insertion (8%) and hematomas (9%). The majority of adverse events (85%) occurred using the first-generation needle-applicator.Conclusion: RFID technology is a potential alternative for non-radioactive and non-wire localization of nonpalpable breast lesions.
AB - Purpose: In breast conserving surgery, accurate lesion localization is essential for obtaining adequate surgical margins. Preoperative wire localization (WL) and radioactive seed localization (RSL) are widely accepted methods to guide surgical excision of nonpalpable breast lesions but are limited by logistical challenges, migration issues, and legislative complexities. Radiofrequency identification (RFID) technology may offer a viable alternative. The purpose of this study was to evaluate the feasibility, clinical acceptability, and safety of RFID surgical guidance for localization of nonpalpable breast cancer.Methods: In a prospective multicentre cohort study, the first 100 RFID localization procedures were included. The primary outcome was the percentage of clear resection margins and re-excision rate. Secondary outcomes included procedure details, user experience, learningcurve, and adverse events.Results: Between April 2019 and May 2021, 100 women underwent RFID guided breast conserving surgery. Clear resection margins were obtained in 89 out of 96 included patients (92.7%), re-excision was indicated in three patients (3.1%). Radiologists reported difficulties with the placement of the RFID tag, partially related to the relatively large needle-applicator (12-gauge). This led to the premature termination of the study in the hospital using RSL as regular care. The radiologist experience was improved after a manufacturer modification of the needle-applicator. Surgical localization involved a low learning curve. Adverse events (n = 33) included dislocation of the marker during insertion (8%) and hematomas (9%). The majority of adverse events (85%) occurred using the first-generation needle-applicator.Conclusion: RFID technology is a potential alternative for non-radioactive and non-wire localization of nonpalpable breast lesions.
KW - Breast cancer
KW - Breast conserving surgery
KW - Primary lesion localization
KW - Radiofrequency identification
KW - RFID
KW - UT-Hybrid-D
UR - http://www.scopus.com/inward/record.url?scp=85162046890&partnerID=8YFLogxK
U2 - 10.1007/s10549-023-07006-x
DO - 10.1007/s10549-023-07006-x
M3 - Article
AN - SCOPUS:85162046890
SN - 0167-6806
VL - 201
SP - 67
EP - 75
JO - Breast cancer research and treatment
JF - Breast cancer research and treatment
ER -
