Rapid photo-crosslinking of fumaric acid monoethyl ester-functionalized poly(trimethylene carbonate) oligomers for drug delivery applications

J. Jansen; Janine Jansen; Mark J. Boerakker; Jean Heuts; Jan Feijen; Dirk W. Grijpma

doi:10.1016/j.jconrel.2010.06.031

Rapid photo-crosslinking of fumaric acid monoethyl ester-functionalized poly(trimethylene carbonate) oligomers for drug delivery applications

J. Jansen, Janine Jansen, Mark J. Boerakker, Jean Heuts, Jan Feijen, Dirk W. Grijpma

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Photo-crosslinkable, fumaric acid monoethyl ester-functionalized poly(trimethylene carbonate) oligomers were synthesized and copolymerized with N-vinyl pyrrolidone (NVP) and vinyl acetate (VAc) to form biodegradable polymer networks. The copolymerization reactions were much faster than homopolymerization of the fumarate end-groups of the macromers. The hydrophilicity of the networks could by varied by mixing NVP and VAc at different ratios. The prepared network extracts were compatible with NIH 3T3 fibroblasts. Release of vitamin B12, used as a model drug, could be tuned by varying network hydrophilicity and macromer molecular weight. A more hydrophilic and less densely crosslinked network resulted in faster release.

Original language	English
Pages (from-to)	54-61
Journal	Journal of controlled release
Volume	147
Issue number	1
DOIs	https://doi.org/10.1016/j.jconrel.2010.06.031
Publication status	Published - 2010

Keywords

IR-76326
METIS-272862

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10.1016/j.jconrel.2010.06.031

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title = "Rapid photo-crosslinking of fumaric acid monoethyl ester-functionalized poly(trimethylene carbonate) oligomers for drug delivery applications",

abstract = "Photo-crosslinkable, fumaric acid monoethyl ester-functionalized poly(trimethylene carbonate) oligomers were synthesized and copolymerized with N-vinyl pyrrolidone (NVP) and vinyl acetate (VAc) to form biodegradable polymer networks. The copolymerization reactions were much faster than homopolymerization of the fumarate end-groups of the macromers. The hydrophilicity of the networks could by varied by mixing NVP and VAc at different ratios. The prepared network extracts were compatible with NIH 3T3 fibroblasts. Release of vitamin B12, used as a model drug, could be tuned by varying network hydrophilicity and macromer molecular weight. A more hydrophilic and less densely crosslinked network resulted in faster release.",

keywords = "IR-76326, METIS-272862",

author = "J. Jansen and Janine Jansen and Boerakker, {Mark J.} and Jean Heuts and Jan Feijen and Grijpma, {Dirk W.}",

year = "2010",

doi = "10.1016/j.jconrel.2010.06.031",

language = "English",

volume = "147",

pages = "54--61",

journal = "Journal of controlled release",

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TY - JOUR

T1 - Rapid photo-crosslinking of fumaric acid monoethyl ester-functionalized poly(trimethylene carbonate) oligomers for drug delivery applications

AU - Jansen, J.

AU - Jansen, Janine

AU - Boerakker, Mark J.

AU - Heuts, Jean

AU - Feijen, Jan

AU - Grijpma, Dirk W.

PY - 2010

Y1 - 2010

N2 - Photo-crosslinkable, fumaric acid monoethyl ester-functionalized poly(trimethylene carbonate) oligomers were synthesized and copolymerized with N-vinyl pyrrolidone (NVP) and vinyl acetate (VAc) to form biodegradable polymer networks. The copolymerization reactions were much faster than homopolymerization of the fumarate end-groups of the macromers. The hydrophilicity of the networks could by varied by mixing NVP and VAc at different ratios. The prepared network extracts were compatible with NIH 3T3 fibroblasts. Release of vitamin B12, used as a model drug, could be tuned by varying network hydrophilicity and macromer molecular weight. A more hydrophilic and less densely crosslinked network resulted in faster release.

AB - Photo-crosslinkable, fumaric acid monoethyl ester-functionalized poly(trimethylene carbonate) oligomers were synthesized and copolymerized with N-vinyl pyrrolidone (NVP) and vinyl acetate (VAc) to form biodegradable polymer networks. The copolymerization reactions were much faster than homopolymerization of the fumarate end-groups of the macromers. The hydrophilicity of the networks could by varied by mixing NVP and VAc at different ratios. The prepared network extracts were compatible with NIH 3T3 fibroblasts. Release of vitamin B12, used as a model drug, could be tuned by varying network hydrophilicity and macromer molecular weight. A more hydrophilic and less densely crosslinked network resulted in faster release.

KW - IR-76326

KW - METIS-272862

U2 - 10.1016/j.jconrel.2010.06.031

DO - 10.1016/j.jconrel.2010.06.031

M3 - Article

SN - 0168-3659

VL - 147

SP - 54

EP - 61

JO - Journal of controlled release

JF - Journal of controlled release

IS - 1

ER -

Rapid photo-crosslinking of fumaric acid monoethyl ester-functionalized poly(trimethylene carbonate) oligomers for drug delivery applications

Abstract

Keywords

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