Rapid, ultrasensitive detection of micro-organisms based on interferometry and lab-on-a-chip nanotechnology

Aurel Ymeti, A. Dudia, P.H.J. Nederkoorn, Paul H.J. Nederkoom, Vinod Subramaniam, Johannes S. Kanger

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

2 Citations (Scopus)

Abstract

Future viral outbreaks are a major threat to societal and economic development throughout the world. A rapid, sensitive, and easy-to-use test for viral infections is essential to prevent and to control such viral pandemics. Furthermore, a compact, portable device is potentially very useful in remote or developing regions without easy access to sophisticated laboratory facilities. We have developed a rapid, ultrasensitive sensor that could be used in a handheld device to detect various viruses and measure their concentration. The essential innovation in this technique is the combination of an integrated optical interferometric sensor with antibody-antigen recognition approaches to yield a very sensitive, very rapid test for virus detection. The sensor is able to spot the herpes virus at concentrations of just 850 particles per milliliter under physiological conditions. The sensitivity of the sensor approaches detection of a single virus particle, yielding a sensor of unprecedented sensitivity with wide applications for viral diagnostics. The sensor's detection principle can be extended to any biological target such as bacteria, cells and proteins and for which there are specific antibodies. The nature of the sensor enables multiplexed detection of several analytes at the same time
Original languageUndefined
Title of host publicationOptics and Photonics in Global Homeland Security V and Biometric Technology for Human Identification VI
EditorsCraig S. Halvorson, Sarka O. Southern, B.V.K. Vijaya Kumar, Salil Prabhakar, Arun A. Ross
PublisherSPIE
Pages73060J-
ISBN (Print)9780819475725
DOIs
Publication statusPublished - 2009

Publication series

NameProceedings of SPIE
PublisherSPIE
Volume7306
ISSN (Print)0277-786X

Keywords

  • Integrated Optics
  • portable device
  • microorganisms
  • Lab on a chip
  • Interferometry
  • rapid detection
  • METIS-259629
  • Nanotechnology
  • Biosensors
  • IR-77739
  • Point of care diagnostics
  • Micro-fluidics

Cite this

Ymeti, A., Dudia, A., Nederkoorn, P. H. J., Nederkoom, P. H. J., Subramaniam, V., & Kanger, J. S. (2009). Rapid, ultrasensitive detection of micro-organisms based on interferometry and lab-on-a-chip nanotechnology. In C. S. Halvorson, S. O. Southern, B. V. K. V. Kumar, S. Prabhakar, & A. A. Ross (Eds.), Optics and Photonics in Global Homeland Security V and Biometric Technology for Human Identification VI (pp. 73060J-). (Proceedings of SPIE; Vol. 7306). SPIE. https://doi.org/10.1117/12.818466