Rationally designed chemical modulators convert a bacterial channel protein into a pH-sensory valve

A. Koçer; M. Walko; E. Bulten; E. Halza; B.L. Feringa; W. Meijberg

doi:10.1002/anie.200503403

Rationally designed chemical modulators convert a bacterial channel protein into a pH-sensory valve

A. Koçer
, M. Walko
, E. Bulten
, E. Halza
, B.L. Feringa
, W. Meijberg^*

^*Corresponding author for this work

TechMed Centre

Research output: Contribution to journal › Article › Academic › peer-review

57 Citations (Scopus)

10 Downloads (Pure)

Abstract

Open channels: Chemical modulators are developed to convert a naturally occurring channel protein into a pH-actuated nanovalve. The pH interval, sensitivity, and activation of the valve by channel opening are tunable through the design of the modulators. The valve is useful for releasing or mixing the contents of liposomes at a desired location, time, and dosage, for example, in micro/nanosensory and delivery devices (see picture).

Original language	English
Pages (from-to)	3126-3130
Journal	Angewandte Chemie - International Edition
Volume	45
Issue number	19
DOIs	https://doi.org/10.1002/anie.200503403
Publication status	Published - 2006

Access to Document

10.1002/anie.200503403

Cite this

@article{35d9b36edb3349239dadcdf1bbc88157,

title = "Rationally designed chemical modulators convert a bacterial channel protein into a pH-sensory valve",

abstract = "Open channels: Chemical modulators are developed to convert a naturally occurring channel protein into a pH-actuated nanovalve. The pH interval, sensitivity, and activation of the valve by channel opening are tunable through the design of the modulators. The valve is useful for releasing or mixing the contents of liposomes at a desired location, time, and dosage, for example, in micro/nanosensory and delivery devices (see picture).",

author = "A. Ko{\c c}er and M. Walko and E. Bulten and E. Halza and B.L. Feringa and W. Meijberg",

year = "2006",

doi = "10.1002/anie.200503403",

language = "English",

volume = "45",

pages = "3126--3130",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "Wiley",

number = "19",

}

TY - JOUR

T1 - Rationally designed chemical modulators convert a bacterial channel protein into a pH-sensory valve

AU - Koçer, A.

AU - Walko, M.

AU - Bulten, E.

AU - Halza, E.

AU - Feringa, B.L.

AU - Meijberg, W.

PY - 2006

Y1 - 2006

N2 - Open channels: Chemical modulators are developed to convert a naturally occurring channel protein into a pH-actuated nanovalve. The pH interval, sensitivity, and activation of the valve by channel opening are tunable through the design of the modulators. The valve is useful for releasing or mixing the contents of liposomes at a desired location, time, and dosage, for example, in micro/nanosensory and delivery devices (see picture).

AB - Open channels: Chemical modulators are developed to convert a naturally occurring channel protein into a pH-actuated nanovalve. The pH interval, sensitivity, and activation of the valve by channel opening are tunable through the design of the modulators. The valve is useful for releasing or mixing the contents of liposomes at a desired location, time, and dosage, for example, in micro/nanosensory and delivery devices (see picture).

UR - https://www.scopus.com/pages/publications/33746216389

U2 - 10.1002/anie.200503403

DO - 10.1002/anie.200503403

M3 - Article

SN - 1433-7851

VL - 45

SP - 3126

EP - 3130

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 19

ER -

Rationally designed chemical modulators convert a bacterial channel protein into a pH-sensory valve

Abstract

Access to Document

Other files and links

Fingerprint

Cite this