Real-Time Monitoring of Nanoparticle Formation by FRET Imaging

Brenda L. Sanchez-Gaytan, Francois Fay, Sjoerd Hak, Amr Muhmed Sabry Abdelhakeem Alaarg, Zahi A. Fayad, Carlos Perez-Medina, Willem J.M. Mulder (Corresponding Author), Yiming Zhao (Corresponding Author)

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Scopus)
86 Downloads (Pure)

Abstract

Understanding the formation process of nanoparticles is of the utmost importance to improve their design and production. This especially holds true for self-assembled nanoparticles whose formation processes have been largely overlooked. Herein, we present a new technology that integrates a microfluidic-based nanoparticle synthesis method and Förster resonance energy transfer (FRET) microscopy imaging to visualize nanoparticle self-assembly in real time. Applied to different nanoparticle systems, for example, nanoemulsions, drug-loaded block-copolymer micelles, and nanocrystal-core reconstituted high-density lipoproteins, we have shown the approach's unique ability to investigate key parameters affecting nanoparticle formation.
Original languageEnglish
Pages (from-to)2923-2926
JournalAngewandte Chemie
Volume56
Issue number11
DOIs
Publication statusPublished - 23 Jan 2017

Keywords

  • METIS-321795
  • IR-103742

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