TY - JOUR
T1 - Recent Advances of Polycationic siRNA Vectors for Cancer Therapy
AU - Bholakant, Raut
AU - Qian, Hongliang
AU - Zhang, Junmei
AU - Huang, Xin
AU - Huang, Dechun
AU - Feijen, Jan
AU - Zhong, Yinan
AU - Chen, Wei
PY - 2020/8/10
Y1 - 2020/8/10
N2 - Small interfering RNAs (siRNAs) have recently emerged as a new class of biopharmaceuticals for the treatment of various diseases, including genetic diseases, viral infections, heritable disorders, and most prominently, cancer. However, clinical applications of siRNA-based therapeutics through intravenous administration have been limited due to their rapid degradation and renal clearance, poor cellular uptake, low cytoplasmic release by escaping endocytic uptake, and off-target effects. The success of siRNA-based therapeutics depends upon the design and creation of efficient delivery vectors that should be able to protect siRNA from in vivo degradation and specifically deliver siRNA to cytosol of target cells. Over the past decade, myriad types of carrier systems composed of cationic polymers have been designed for delivery of siRNA to tumor cells. In this review, we overview recent advances in siRNA delivery by using these promising nonviral carrier systems in diverse approaches to overcome the delivery hindrances and provide valuable understanding to direct the future design of siRNA delivery carriers.
AB - Small interfering RNAs (siRNAs) have recently emerged as a new class of biopharmaceuticals for the treatment of various diseases, including genetic diseases, viral infections, heritable disorders, and most prominently, cancer. However, clinical applications of siRNA-based therapeutics through intravenous administration have been limited due to their rapid degradation and renal clearance, poor cellular uptake, low cytoplasmic release by escaping endocytic uptake, and off-target effects. The success of siRNA-based therapeutics depends upon the design and creation of efficient delivery vectors that should be able to protect siRNA from in vivo degradation and specifically deliver siRNA to cytosol of target cells. Over the past decade, myriad types of carrier systems composed of cationic polymers have been designed for delivery of siRNA to tumor cells. In this review, we overview recent advances in siRNA delivery by using these promising nonviral carrier systems in diverse approaches to overcome the delivery hindrances and provide valuable understanding to direct the future design of siRNA delivery carriers.
UR - http://www.scopus.com/inward/record.url?scp=85089612793&partnerID=8YFLogxK
U2 - 10.1021/acs.biomac.0c00438
DO - 10.1021/acs.biomac.0c00438
M3 - Review article
C2 - 32568525
AN - SCOPUS:85089612793
VL - 21
SP - 2966
EP - 2982
JO - Biomacromolecules
JF - Biomacromolecules
SN - 1525-7797
IS - 8
ER -